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The Leukemias: Etiology, Pathophysiology, and Treatment - 1st Edition - ISBN: 9781483229799, 9781483263755

The Leukemias: Etiology, Pathophysiology, and Treatment

1st Edition

Editors: John W. Rebuck Frank H. Bethell Raymond W. Monto
eBook ISBN: 9781483263755
Imprint: Academic Press
Published Date: 1st January 1957
Page Count: 730
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The Leukemias: Etiology, Pathophysiology, and Treatment documents the proceedings of an International Symposium on The Leukemias: Etiology and Pathophysiology, held at Henry Ford Hospital, Detroit, Michigan, 8-10 March 1956. This volume gives the present complex position of leukemic etiology and pathophysiologic disturbance, a much needed knowledge of detailed leukocytic functions and comprehensive thought on the therapy of the leukemias. It also establishes a basis of comparison with the earlier works of Downey and Forkner in this field in the late thirties and thus makes it possible to see with some clarity the extent of progress made. The volume contains 39 papers organized into nine parts. The papers in Part I focus on the leukemic cell, its structure, and antigenicity. Part II presents studies on genetic and environmental factors in the transmission of leukemia. Part III examines the radiation biology of leukocytes. Part IV focuses on the leukemias and the malignant lymphomas while Part V deals with leukocytic physiology. Part VI covers the metabolism of amino and nucleic acids in the leukemias. Part VII takes up further biochemical considerations in the leukemias. Part VIII contains papers that examine nucleic acids as the target for chemotherapy. Part IX presents a round-table discussion on therapy.

Table of Contents


Part I: The Leulcemic Cell, Its Structure and Antigenicity

1. Electron Microscopy of Normal and Leulcemic Leukocytes

Added Comment

2. Phase-Contrast Microscopy of Leukocytes

Added Comment

General Discussion

3. Antigenicity of Leukocyte Fractions

4. Some Studies on Leukocyte Agglutinins

Added Comment

General Discussion

Part II: Genetic and Environmental Factors in the Transmission of Leukemia

5. The Pathophysiology and Immunogenetics of Transplantable Leukemia

6. Genetic and Nongenetic Factors Influencing the Induction of Mouse Leukemia

7. Viral Etiology of Mouse Leukemia

Added Comment

General Discussion

8. Environmental Factors in Human Leukemia

Part III: Radiation Biology of Leukocytes

9. Radiation Injury and Regeneration in Lymphoid Tissues

10. Cytocidal Action of X-Rays on Lymphocytes According to Time-Lapse Cinemicrography and Unstained Cell Counts

Added Comment

Added Comment

General Discussion

Part IV: The Leukemias and the Malignant Lymphomas

11. The Leukemias—Their Scope

12. The Malignant Lymphomas

Part V: Leukocytic Physiology

13. Cultivation of Leukemic Cells in the Cartesian Diver

14. Observations on Human Leukemic Cells in Culture

15. Newer Concepts of Leukopoiesis as Revealed by Leukopheretic and Isotopic Techniques

16. Endocrine Influences on Blood Formation

Added Comment

General Discussion

17. The Influence of Cellular Fractions of Whole Blood on the Course of Acute Lymphocytic Leukemia: A Preliminary Report

18. The Leukocytic Resistance Test

General Discussion

Part VI: Metabolism of Amino and Nucleic Acids in the Leukemias

19. Some Aspects of Amino Acid Metabolism in Leukemia

20. Urinary Amino Acid Excretion in Leukemia

21. Free or Easily Extractable Amino Acids in Blood Cells and Body Fluids

General Discussion

22. Metabolic Stability of PNA and DNA in Human Leukemic Leukocytes; The Function of Lymphocytes

23. Urinary Uric Acid Excretion in Leukemia

24. Nucleic Acids, Nucleases, and Nuclease Inhibitors in Leukemia

25. Studies on Cysteine Metabolism in Leukemia

General Discussion

Part VII: Further Biochemical Considerations in the Leukemias

26. Immunologic Studies of Protein Synthesis in Leukemia

27. Biochemical and Enzymatic Characteristics of Normal and Leukemic Leukocytes (with Particular Reference to Leukocyte Alkaline Phosphatase)

28. Metabolism of Folic Acid and Citrovorum Factor in Leukemic Cells

Added Comment: Labeling of RNA of Rabbit Peritoneal Exudate Polymorphonuclear Leukocytes

General Discussion

29. Lactic Acid Production by Polymorphonuclear Leukocytes

30. Diagnostic and Nosological Problems at the Borderline of Leukemia

General Discussion

Part VIII: Nucleic Acids as the Target for Chemotherapy: Mechanisms of Drug Action and Resistance

31. Nucleic Acids and Related Derivatives as Targets for Chemotherapy

32. Uracil Antagonists As Inhibitors of Transplantable Tumors

33. The Specific Action of Azaserine on Enzymes Concerned with Purine Biosynthesis

34. Nucleotide Metabolism and Cancer Chemotherapy

General Discussion

35. Purine Nucleotide Biosynthesis and Neoplasia

36. Anticancer Agents and Nucleic Acid Metabolism of Isolated Human Leukocytes

37. Studies on Resistance to Folic Acid Antagonists

38. Metabolic and Nutritional Variations in Drug-Resistant Streptococcus Faecalis

General Discussion

39. Round-Table Discussion on Therapy

Author Index

Subject Index


No. of pages:
© Academic Press 1957
1st January 1957
Academic Press
eBook ISBN:

About the Editors

John W. Rebuck

Frank H. Bethell

Raymond W. Monto

Ratings and Reviews