The Lancet Handbook of Essential Concepts in Clinical Research

1st Edition

Editors:

  • Kenneth Schulz
  • David Grimes
    • Print ISBN 9780080450377

    Key Features

    • Enables clinicians to read the medical literature more critically
    • Chapters cover: descriptive studies, cohort studies, case control studies, bias, and screening tests
    • Five chapters dedicated to randomized controlled trials

    Table of Contents

    An overview of clinical research: the lay of the land.
    Descriptive studies: what they can and cannot do.
    Bias and causal associations in observational research.
    Cohort studies: marching towards outcome.
    Case-control studies: research in reverse.
    Generation of allocation sequences in randomized trials: chance, not choice.
    Allocation concealment in randomized trials: defending against deciphering.
    Sample size slippages in randomized trials: exclusions and the lost and wayward.
    Blinding in randomized trials: hiding who got what.
    Uses and abuses of screening tests.
    Unequal group sizes in randomized trials: guarding against guessing.
    Sample size calculations in randomized trials: mandatory and mystical.
    Compared to what? Finding controls for case-control studies.
    Refining clinical diagnosis with likelihood ratios.
    Multiplicity in randomized trials I: endpoints and treatments.
    Multiplicity in randomized trials II: subgroup and interim analyses.

    Details

    No. of pages:
    242
    Language:
    English
    Copyright:
    © 2006
    Published:
    Imprint:
    The Lancet
    Print ISBN:
    9780080450377

    About the editors

    Kenneth Schulz

    Affiliations and Expertise

    Vice President of Quantitative Sciences, Family Health International, Research Triangle Park, NC; Clinical Professor, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, NC, USA

    David Grimes

    Affiliations and Expertise

    Vice President of Biomedical Affairs, Family Health International, Research Triangle Park, NC; Clinical Professor, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC, USA