The Inflammatory Process

The Inflammatory Process

1st Edition - January 1, 1965

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  • Editors: Benjamin W. Zweifach, Lester Grant, Robert T. McCluskey
  • eBook ISBN: 9781483261706

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The Inflammatory Process focuses on the approaches, methodologies, and technologies involved in the study of the inflammatory process, including capillary structure, tissue injury, and inflammatory response. The selection first offers information on the experimental approach to inflammation, ultrastructural and biochemical consequences of cell injury, and ultrastructural basis of capillary permeability. Discussions focus on permeability of capillaries, cytoplasm, nucleus, gross pathology of inflammation, light microscope and the study of inflammation, and the physiologic approach to problems of inflammation. The text then elaborates on the microvascular aspects of tissue injury and the sticking and emigration of white blood cells in inflammation. The book examines neutrophil and eosinophil leucocytes, "life history" and functions of lymphocytes, and metabolism and physiology of mononuclear phagocytes. Topics include inflammatory response, biochemistry and metabolism, special relationships to bacteria and viruses, and origins and early development of lymphocytes. The text also ponders on the role of lysosomes in tissue injury, hemostatic mechanisms in tissue injury, and anti-inflammatory agents. The selection is a vital source of data for researchers interested in the inflammatory process.

Table of Contents

  • Contributors


    Chapter 1 The Experimental Approach to Inflammation

    I. Introduction

    II. The Gross Pathology of Inflammation

    III. The Light Microscope and the Study of Inflammation

    IV. Bacteriology and Immunology

    V. Phagocytosis

    VI. Chemotaxis

    VII. The Physiologic Approach to Problems of Inflammation

    VIII. Chemical Mediators of Inflammation

    IX. The Electron Microscope and Changes in Ultrastructure

    X. Conclusion


    Chapter 2 Some Ultrastructural and Biochemical Consequences of Cell Injury

    I. Introduction

    II. The Cytoplasm

    III. The Nucleus

    IV. Concluding Remarks


    Chapter 3 The Ultrastructural Basis of Capillary Permeability

    I. Introduction

    II. Permeability of Capillaries

    III. Capillary Structure

    IV. Discussion of Various Mechanisms Proposed for the Control of Capillary Permeability

    V. Summary and Conclusions


    Chapter 4 Microvascular Aspects of Tissue Injury

    I. General Aspects of Reaction

    II. Specific Components

    III. Summary Statement


    Chapter 5 The Sticking and Emigration of White Blood Cells in Inflammation

    I. Introduction

    II. History of the Problem

    III. Fate of Emigrated Cells in the Extravascular Tissues

    IV. The Influence of pH on the Emigration of White Cells

    V. Relationship Between White Cell Sticking and Vascular Permeability

    VI. Chemotaxis

    VII. Electrochemical Factors

    VIII. Summary


    Chapter 6 Neutrophil and Eosinophil Leucocytes

    I. Introduction

    II. Neutrophil Leucocytes

    III. The Eosinophil Leucocyte


    Chapter 7 The "Life History" and Functions of Lymphocytes

    I. Introduction

    II. General Description of Lymphocytes

    III. Origins and Early Development of Lymphocytes

    IV. "Life Span" and Turnover of Small Lymphocytes

    V. Recirculation of Small Lymphocytes

    VI. Alleged Transformations of Lymphocytes into Other Cell Types

    VII. The Proposed Trephocytic Function of Lymphocytes

    VIII. The Immunologic Activity of Lymphocytes

    IX. Summary and Conclusions


    Chapter 8 The Metabolism and Physiology of the Mononuclear Phagocytes

    I. Introduction and Historical Development

    II. Nomenclature

    III. Morphology

    IV. Distribution

    V. Origin

    VI. Development and Differentiation

    VII. Biochemistry and Metabolism

    VIII. The Inflammatory Response

    IX. Functional Properties

    X. Special Relationships to Bacteria and Viruses


    Chapter 9 Structural and Biochemical Characteristics of Mast Cells

    I. Introduction

    II. Origin and Distribution of Mast Cells

    III. Normal Tissue Mast Cells; Neoplastic Mast Cells

    IV. Mast Cell Cytology

    V. Biochemistry of the Mast Cells

    VI. Functional View of the Tissue Mast Cell

    VII. Mast Cells in Pathologic Disorders

    VIII. Concluding Remarks


    Chapter 10 Chemical Mediators. I

    I. Introduction

    II. Early Vascular Events in Inflammation

    III. Endogenous Mediators of the Vascular Events

    IV. Evidence for the Natural Role of Proteases, Polypeptides, and Amines in the Inflammatory Process

    V. Investigations of Other Possible Mediators in Inflammation

    VI. Conclusions


    Chapter 11 Chemical Mediators. II

    I. Histamine

    II. 5-Hydroxytryptamine

    III. Epinephrine and Norepinephrine

    IV. Conclusions


    Chapter 12 The Role of Lysosomes in Tissue Injury

    I. The Lysosome Concept

    II. Vitamin A and Lysosomes

    III. Stabilization of Lysosomes by Cortisone

    IV. Ultraviolet Light and Lysosomes

    V. Lysosomes in Endotoxin Shock

    VI. Streptolysins and Lysosomes

    VII. Leucocyte Granules and Tissue Injury

    VIII. Lysosomes and Tissue Necrosis

    IX. Summary


    Chapter 13 Hemostatic Mechanisms in Tissue Injury

    I. Introduction

    II. The Hemostatic Plug

    III. Vascular and Tissue Factors in Hemostasis

    IV. Hemostasis as a Whole


    Chapter 14 Fever

    I. Introduction

    II. Historical

    III. Experimental Models for Investigating the Pathogenesis of Fever

    IV. Endogenous Pyrogens

    V. Clinical


    Chapter 15 Fibroplasia: A Sequel to Lymphocyte Exudation

    I. Introduction: Development of Concepts Relating Fibroplasia to Leucocyte Exudation

    II. Origin of the Blastema in Amphibian Regeneration

    III. Studies of Lymphocyte Participation in Tissue Repair in Mammals

    IV. Experiments with Labeled Cells

    V. The "Transforming Principle" and Fibroplasia

    VI. Synthesis of Collagen as a Functional Characteristic of Certain Connective Tissue Cells

    VII. Conclusion


    Chapter 16 Anti-Inflammatory Agents

    I. Introduction

    II. The Influence of Experimental Conditions Upon the Inflammatory Reaction

    III. Anti-Inflammatory Agents


    Chapter 17 Delayed Hypersensitivity

    I. Introduction

    II. Different Types of Delayed Hypersensitivity Reactions

    III. Immunologic Specificity of Delayed Reactions

    IV. Passive Transfer

    V. Gross and Histologic Appearance

    VI. Cellular Studies

    VII. Desensitization


    Chapter 18 Anaphylaxis: Systemic, Local Cutaneous and In Vitro

    I. Introduction

    II. Properties of the Pharmacologic Mediators

    III. Systemic Anaphylaxis

    IV. Local Cutaneous Anaphylaxis

    V. In Vitro Anaphylaxis

    VI. Concluding Comments


    Chapter 19 The Arthus Reaction

    I. Introduction

    II. Production of the Arthus Reaction

    III. Antibodies Inefficient in Provoking Arthus Reactions

    IV. Mediators of the Arthus Reaction

    V. Differentiation of the Arthus Vasculitis from Other Inflammatory Vascular Reactions

    VI. Healing of the Reaction


    Chapter 20 Experimental Serum Sickness

    I. Introduction and Historical Background

    II. Experimental Production of Lesions with Foreign Serum

    III. Experimental Production of Lesions with Purified Heterologous Proteins

    IV. Structural Aspects of the Lesions of Serum Sickness

    V. Analysis of Immune Events in Course of Serum Sickness

    VI. Tissue Damaging Properties of Soluble Antigen-Antibody Complexes

    VII. Character and Distribution of Lesions Produced in Rabbits by Prolonged Repeated Injections

    VIII. Factors Affecting the Localization of Circulating Antigen-Antibody Complexes

    IX. Other Pathogenic Factors in Serum Sickness


    Chapter 21 Inflammation in Homograft Rejection

    I. Introduction

    II. General Pattern of Inflammation in Homograft Rejection

    III. Rejection Patterns in Different Tissues and Organs

    IV. Discussion


    Chapter 22 Autoimmune Diseases

    I. Introduction

    II. Testis

    III. Lens

    IV. Uvea

    V. Nervous Tissue

    VI. Thyroid

    VII. Generalized Autoimmune Diseases

    VIII. Discussion

    IX. Perspectives


    Chapter 23 The Cellular Basis of Antibody Formation

    I. Introduction

    II. The Histology of the Primary and Secondary Antibody Response

    III. The Role of the Reticuloendothelial System in Antibody Formation

    IV. Modification of the Antibody Response by Adjuvants

    V. Plasma Cell

    VI. Cellular Origin of Different Classes of Immunoglobulins

    VII. Antibody Formation by Single Cells

    VIII. Antibody Formation During Inflammation

    IX. Agammaglobulinemia

    X. Germ-Free Animals

    XI. Summary


    Chapter 24 The Local and Generalized Shwartzman Phenomena

    I. Introduction

    II. Local Shwartzman Phenomenon

    III. Generalized Shwartzman Phenomenon


    Chapter 25 The Role of Complement in Immune Phenomena

    I. Introduction

    II. The Complement System—General Considerations

    III. Specific Immune Phenomena Involving Antibody and Complement


    Contributors: Biographical Sketches

    Author Index

    Subject Index

Product details

  • No. of pages: 948
  • Language: English
  • Copyright: © Academic Press 1965
  • Published: January 1, 1965
  • Imprint: Academic Press
  • eBook ISBN: 9781483261706

About the Editors

Benjamin W. Zweifach

Lester Grant

Robert T. McCluskey

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