The Importance of laboratory animal genetics Health, and the Environment in Biomedical Research - 1st Edition - ISBN: 9780124895201, 9780323157032

The Importance of laboratory animal genetics Health, and the Environment in Biomedical Research

1st Edition

Editors: Edward C. Jr. Melby
eBook ISBN: 9780323157032
Imprint: Academic Press
Published Date: 1st January 1984
Page Count: 300
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Description

The Importance of Laboratory Animal Genetics, Health, and the Environment in Biomedical Research documents the proceedings of the Fifth Charles River International Symposium on Laboratory Animals, in Heidelberg, Federal Republic of Germany, March 14-16, 1983. These papers examine how the health and genetic monitoring of laboratory animals, coupled with environmental influences, affect the investigations of oncologists, toxicologists, or pharmacologists.
The book is organized into four parts. Part I focuses on the health monitoring of laboratory animals for biomedical research. It includes studies on the effects of health and health monitoring in toxicology studies, oncology studies, and pharmacologic studies. Part II deals with the genetic monitoring of laboratory animals. It examines the causes of genetic alternation in laboratory animals and ways to prevent them. Part III considers the environmental monitoring that is necessary for research on laboratory animals. Part IV on new research frontiers includes studies on the production of monoclonal antibodies for the experimental and therapeutic modulation of laboratory animals, and the quality control aspects of animal experimentation.

Table of Contents


Contributors

Participants

Preface

Introductory Remarks

Part I Health Monitoring: Interpretation and Importance to Biomedical Research

Overview of the State of the Art in Health Monitoring

The Effects of Health and Health Monitoring on Toxicology Studies

The Effects of Health and Health Monitoring on Oncology Studies

The Effects of Health and Health Monitoring on Pharmacologic Studies

Part II Genetic Monitoring: Interpretation and Importance to Biomedical Research

Overview of the State of the Art in Genetic Monitoring

Malformations of Genetic Origin in Teratology Studies: Cases of Cleft Palate in Rabbits

The Impact of Genetics and Genetic Monitoring on Oncological Studies—Some Aspects of Leukemogenesis in the AKR Strain

Impact of Genetics and Genetic Monitoring on Pharmacology Studies

Part III Environmental Monitoring: Interpretation and Importance to Biomedical Research

Overview of the State of the Art in Environmental Monitoring

The Effects of Environment and Environmental Monitoring on Toxicology Studies

The Effects of Environment and Environmental Monitoring on Oncology Studies

The Effects of Environment and Environmental Monitoring on Pharmacology Studies

Part IV New Research Frontiers: Importance of the Laboratory Animal

Monoclonal Antibodies—Importance of the Laboratory Animal

The Importance of Laboratory Animal Genetics, Health, and Environment—The Laboratory Animal Specialist's Viewpoint

Quality Animals for Biomedical Research: Lessons from the Past, Opportunities for the Future

MHC, Mice, Men, and Businessmen

Index

Details

No. of pages:
300
Language:
English
Copyright:
© Academic Press 1983
Published:
Imprint:
Academic Press
eBook ISBN:
9780323157032

About the Editor

Edward C. Jr. Melby