The Guide to Investigation of Mouse Pregnancy

1st Edition

Editors: B. Anne Croy Aureo Yamada Francesco DeMayo S. Lee Adamson
Hardcover ISBN: 9780123944450
eBook ISBN: 9780123947949
Imprint: Academic Press
Published Date: 30th January 2014
Page Count: 832
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Description

The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells.

Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research.

Key Features

  • Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications
  • Describes the angiogenic tree the mother’s uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes
  • Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation
  • Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success

Readership

This book is intended for basic scientists and clinical investigators researching reproduction, immunology, developmental biology, cardiology, gynecology, animal care, and veterinary medicine; graduate students; postdocs; veterinary technologists; and laboratory technologists.

Table of Contents

Biographies

Preface

Conception of This Publication

Goals

The Many Thank Yous Over the Course of This Project

Contributors

Part I: Atlas

1. The Cycling and Pregnant Mouse: Gross Anatomy

Chapter Summary

Abbreviations

Introduction

Anatomic Changes in the Appearance of the Cycling and Pregnant Uterus

Death of a Conceptus Does not Mean Pregnancy Failure

Postpartum Uterine Involution

Illustrative Plates

References

2. Implant Site Dissections

Chapter Summary

Abbreviations

Introduction

Dissection of Gestation Day 6.5–9.5 Uteri and Implant Sites

Collection of the MLAp

Dissection of Uteri and Implant Sites between Gestation Day 10.5 and Term

Illustrative Plates

References

3. Microscopic Anatomy of the Pregnant Mouse Uterus Throughout Gestation

Chapter Summary

Abbreviations

Introduction

4. Anatomy of the Mouse Placenta Throughout Gestation

Chapter Summary

Abbreviations

5. Whole-Mount Immunohistochemistry of Early Implantation Sites

Chapter Summary

Abbreviations

Introduction

Benefits and Limitations

Whole-Mount Atlas Plates

References

6. Magnetic Resonance Imaging of the Mouse Placenta

Chapter Summary

Introduction

Methods

Future Perspectives

References

Part II: Basic Biology

Interval A. Estrus, Early Development, Implantation and Uterine Receptivity

7. Reproductive Tract Changes During the Mouse Estrous Cycle

Chapter Summary

Acknowledgments

Introduction

Female Mouse Reproductive Tract Anatomy

The Mouse Estrous Cycle

References

8. First Cell Fate Decisions in Early Development: Towards Establishment of the Trophoblast Lineage

Chapter Summary</P

Details

No. of pages:
832
Language:
English
Copyright:
© Academic Press 2014
Published:
Imprint:
Academic Press
eBook ISBN:
9780123947949
Hardcover ISBN:
9780123944450
Paperback ISBN:
9780128100943

About the Editor

B. Anne Croy

Affiliations and Expertise

Dept. of Biomedical and Molecular Sciences, School of Medicine, Queen's University, ON, Canada

Aureo Yamada

Affiliations and Expertise

Instituto de Biologia, Universidade Estadual de Campinas, Campinas, Brazil

Francesco DeMayo

Affiliations and Expertise

Developmental Biology, Baylor College of Medicine,TX, U.S.A.

S. Lee Adamson

Affiliations and Expertise

Samuel Lunenfeld Research Institute of Mount Sinai Hospital,ON,Canada

Reviews

"The editors must be congratulated with this book, which will be extremely useful to all investigators who are focussing on this most popular animal model."--Placenta, November 28, 2014

"The text is clear and concise and contains something for beginning and expert investigators alike...This book will be a valued addition to the library of any pregnancy researcher who uses mice as their model organism."--Journal of the American Veterinary Medical Association, 15-Sep-14