Description

Over 50% of known flaviviruses have been associated with human disease. The Flavivirus genus constitutes some of the most serious human pathogens including Japanese encephalitis, dengue and yellow fever. Flaviviruses are known for their complex life cycles and epidemic spread, and are considered a globally-emergent viral threat. Pathogenesis and Immunity, the second volume of The Flaviviruses, examines the processes by which the flaviviruses cause disease, the different cytopathic effects and the associated immunopathological responses produced in their hosts.

Key Features

* Comprehensive approach to the scientific disciplines needed to unravle the complexities of virus-host interactions. * New, detailed information on the pathogenesis and immunology of the Flavivirus family. * Descibes the technologies that have contributed to our current knowledge about the Flaviviruses. * Identifies the major problems faced in attempting to further understand the virus-host interactions that result in disease. * An exhaustive compendium of current and past knowledge on the Flavivirus family

Readership

Virologists, molecular epidemiologists, clinicians and public health specialists, immunologists, and researchers in vaccine development

Table of Contents

Pathogenesis and Immunity Molecular Determinants of Virulence: The Structural and Functional Basis for Flavivirus Attenuation Genetic resistance to flaviviruses Immunobiology of mosquito-borne encephalitic Flaviviruses Immune Modulation by Flaviviruses Mechanisms of virus-induced cell death Dynamics of Flavivirus Infection in Mosquitos Dynamics of Infection in Tick vectors and at the tick-host interface Encephalitic viruses Pathogenesis and Pathophysiology of Yellow Fever virus Immunopathogenesis of dengue hemorrhagic fever Immunology and Immunopathogenesis of Dengue Disease Neutralization and Antibody-Dependent Enhancement of Dengue Viruses

Details

No. of pages:
486
Language:
English
Copyright:
© 2003
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080493824
Print ISBN:
9780120398607

About the serial-volume-editors

Reviews

"...the chapters are well written, and the editors have ensured continuity of a high standard of writing throughout the set...Given the wealth of information, with contributions by over 60 authors, The Flavaviruses, really is an essential series of books that belongs on every arbovirologists’ bookshelf." -Stephen Higgs, Ph.D., University of Texas Medical Branch, U.S., (2004)