The Eye
Basic Sciences in Practice
- 5th Edition - October 18, 2020
- Authors: John V. Forrester, Andrew D. Dick, Paul G McMenamin, Fiona Roberts, Eric Pearlman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 7 0 2 0 - 7 9 9 3 - 1
- eBook ISBN:9 7 8 - 0 - 7 0 2 0 - 7 9 9 4 - 8
The Eye: Basic Sciences in Practice provides highly accessible, one-stop coverage of all the essential basic science required by today’s ophthalmologists and optometrists in tr… Read more
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Request a sales quoteThe Eye: Basic Sciences in Practice provides highly accessible, one-stop coverage of all the essential basic science required by today’s ophthalmologists and optometrists in training. It is also core reading for those embarking on a career in visual and ophthalmic science, as well as an invaluable, current refresher for the range of practitioners working in this area.
Building on previous success, this fifth edition has been fully revised in line with current curricula, key research developments and clinical best practice. It succinctly incorporates critical developments in fast-moving fields related to the eye and vision, including genetics, pharmacology, microbiology, immunology, pathology, neurophysiology, neuroanatomy and imaging. Topical coverage includes:
Major advances in the search for new genes underpinning disease in ophthalmology
The emergence of new infections such as Ebola, Zika and COVID-19
The importance of the gastrointestinal tract as an immune organ and its functional dependence on the microbiome
Key aspects of melanopsin, melatonin and new ways of light sensing
Also, (print purchasers) benefit from access to the complete, fully searchable electronic text, with integrated video and other bonus materials to further explain and expand on key concepts. This combines to make The Eye a more flexible, comprehensive and engaging learning package than ever before.
- Instructions for online access
- Cover image
- Title page
- Table of Contents
- Copyright
- eBook Content
- Preface
- Acknowledgements
- Chapter 1. Anatomy of the eye and orbit
- Anatomical terms of reference
- Osteology of the skull and orbits
- Structure of the eye
- Orbital contents
- Cranial nerves associated with the eye and orbit
- Ocular appendages (adnexa)
- Anatomy of the visual pathway
- Chapter 2. Embryology and early development of the eye and adnexa
- Introduction
- General embryology
- Ocular embryology: general introduction
- Periocular mesenchyme is derived from a mixture of neural crest and mesoderm
- The neural retina and retinal pigment epithelium are derived from neuroepithelium
- Optic nerve and disc development
- Development of the fibrous coat of the eye
- Development of the intraocular contents
- Development of the uveal tract
- Development of the anterior chamber angle and aqueous outflow pathways
- Development of extraocular muscles
- Chapter 3. Genetics
- Introduction
- Chromosomes and cell division
- Molecular genetics (DNA and genes)
- Chromosome defects and gene mutations
- Clinical genetics
- Population genetics
- Understanding the human genome: DNA analysis
- Molecular biology and clinical medicine
- Molecular and cell biology: controlling cell destiny
- Molecular genetics and ophthalmology
- Chapter 4. Biochemistry and cell biology
- Introduction
- The ‘omics’ creed
- Cells and tissues
- Biochemical pathways that affect ocular function
- The ocular surface
- Cornea and sclera
- The uveal tract
- Aqueous humour dynamics
- The lens
- The vitreous body
- The retina
- The chemistry of the visual response
- Conclusion
- Chapter 5. Physiology of vision and the visual system
- Introduction
- Light detection and dark adaptation
- Visual acuity and contrast sensitivity
- Electrophysiology of the visual system
- Colour vision
- Visual perception
- Division of labour in the visual system: parcellation and the human connectome
- Physiology of ocular movement
- Conclusion
- Chapter 6. General and ocular pharmacology
- Introduction
- Pharmacokinetics: drug trafficking in the body
- Pharmacodynamics: drug handling by the body
- Drug–receptor interactions
- Ocular pharmacology: drug handling by cells and tissues of the eye
- Delivery methods of ocular medication
- Reconstituting the tear film
- Ocular drugs and the autonomic nervous system
- Clinical control of intraocular pressure exploits the adrenergic system
- A drug-free approach to treating glaucoma
- The histaminergic system: histamine is released from conjunctival mast cells during allergic reactions
- Eicosanoids affect multiple ocular functions
- Serotonin: a potent neurotransmitter
- Glucocorticoids
- Immunosuppressant agents: combating ocular inflammatory disease
- Local anaesthetics: an integral part of ophthalmic examination and surgery
- Ocular toxicity from systemic administration of drugs
- Chapter 7. Immunology
- Introduction
- Overview of the immune system
- Cells and molecules of the immune system
- Initial response of the host to injury (the innate immune response)
- Development of adaptive immunity and immunological memory
- Effector mechanisms
- Organization of the immune system
- Antigen recognition
- The major histocompatibility system
- T-cell activation
- B-cell activation
- Tolerance and autoimmunity
- Allergy and immediate hypersensitivity
- Organ and tissue transplantation
- Tumours induce immune responses but not very effectively
- The eye and the immune system
- Conclusion
- Chapter 8. Microbial infections of the eye
- Introduction
- Source of microbes that cause ocular infections
- Host defences at the ocular surface
- Viral infections of the eye
- Chapter 9. Pathology
- Introduction
- Cell and tissue damage
- Healing and repair
- Inflammation
- Metabolic disease
- Ageing, degeneration and dystrophies
- Neoplasia
- Addendum
- Index
- No. of pages: 576
- Language: English
- Edition: 5
- Published: October 18, 2020
- Imprint: Elsevier
- Hardback ISBN: 9780702079931
- eBook ISBN: 9780702079948
JF
John V. Forrester
Affiliations and expertise
Professor of Ophthalmology and Head of Department of Ophthalmology, University of Aberdeen, UK; Section of Immunology and Infection, University of Aberdeen, UK; Ocular Immunology Program, The University of Western Australia, Australia; Centre for Experimental Immunology, Lions Eye Institute, Western Australia, AustraliaAD
Andrew D. Dick
Affiliations and expertise
Professor of Ophthalmology and Head of Academic Unit of Ophthalmology, University of Bristol; Director, UCL-Institute of Ophthalmology, University College London, London, UKPM
Paul G McMenamin
Affiliations and expertise
Director of the Centre for Human Anatomy Education, Department of Anatomy & Developmental Biology, Monash University, Melbourne, Victoria, AustraliaFR
Fiona Roberts
Affiliations and expertise
Consultant Ophthalmic Pathologist, Queen Elizabeth University Hospital, and Honorary Senior Lecturer in Pathology, University Department of Pathology, Glasgow, UKEP
Eric Pearlman
Affiliations and expertise
Director, Institute of Immunology, Professor, Departments of Ophthalmology and Physiology, University of California, Irvine; Professor and Director of Research. Department of Ophthalmology and Visual Sciences, Case Western Reserve University.