The Encyclopedia of Mass Spectrometry - 1st Edition - ISBN: 9780080438047, 9780080913216

The Encyclopedia of Mass Spectrometry

1st Edition

Volume 5: Elemental and Isotope Ratio Mass Spectrometry

Series Volume Editors: Diane Beauchemin Dwight Matthews
eBook ISBN: 9780080913216
Hardcover ISBN: 9780080438047
Imprint: Elsevier Science
Published Date: 30th July 2010
Page Count: 1088
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Volume 5: Elemental and Isotope Ratio Mass Spectrometry focuses on (1) the plethora of mostly atomic ionization techniques that have been coupled to MS for elemental analysis, the measurement of isotope ratios, and even the determination of inorganic compounds and (2) the precise measurement of isotope ratios of organic elements as small gas molecules by isotope ratio mass spectrometry (IRMS).

Key Features

  • Reviews the wide range of ionization and isotope methods used in inorganic mass spectrometry today
  • Features tutorials describing the key principles and instrumentation relevant to each method
  • Evaluates practical applications for the analysis of environmental, biological, biomedical, nutritional, geological, nuclear, microelectronic and extra-terrestrial materials
  • Includes more than 3400 references, 100 tables and 500 figures of which more than 200 are in color


Advanced research scientists, mass spectrometrists, spectroscopists, analytical chemists and those working in related fields

Table of Contents

Sample Preparation Techniques in Inductively Coupled Plasma Mass Spectrometry; Sample Introduction: Nebulization; Sample introduction: Laser ablation; Sample introduction: Electrothermal vaporization; Sample introduction: Capillary electrophoresis; Sample introduction: Gas chromatography; Sample introduction: Liquid chromatography; Sample Introduction: Vapour Generation; Sample introduction: Flow injection; Inductively Coupled Plasma as an Ion Source for Mass Spectrometry; Ion extraction from inductively coupled plasma; Mass analyzers (quadrupole, time-of-flight & sector); Reduction of polyatomic interferences in ICP-MS by collision/reaction cell (CRC-ICP-MS) techniques; Interferences: Polyatomic ions with double-focusing sector field; Interferences: Non-spectroscopic interferences; Application of Inductively Coupled Plasma Mass Spectrometry to Environmental Analysis; Application of ICP-MS for Elemental Analysis of geochemical samples; Applications: Semiconductor materials; Applications: Determination of long-lived radionuclides in nuclear, environmental and medical materials by ICP-MS and LA-ICP-MS; Applications: Speciation - biomolecules; Applications: Speciation - small molecules; ELEMENTAL SPECIATION IN BIOPOLYMERS BY ICP-MS; Applications: High precision isotope ratio measurements using multiple collector inductively coupled plasma mass spectrometry; Microwave plasma mass spectrometry; Diagnostic studies of flames by mass spectrometry; Glow discharge basics; Ion source geometries and mass analyzers in glow discharge mass spectrometry; Glow discharge applications: Conductors and semiconductors; Glow discharge applications: Radiofrequency glow discharges for insulators; Glow discharge applications: Nuclear; Control of fragmentation; Spark Source Mass Spectrometry (Spectrography); Electrospray ionization of metal species; Characterization of inorganic species in solution; Secondary Ion Mass Spectrometry - SIMS; Sputtering and ionization basics; SIMS imaging; Imaging ion optics in SIMS; SIMS depth profiling; Secondary neutral mass spectrometry (SNMS); Subcellular imaging of cells and tissues with dynamic secondary ion mass spectrometry; Semi-conductors and microelectronics; Local analysis and imaging by mass spectrometry in nanotechnology; Earth sciences, isotope ratios, sensitive high-resolution ion microprobe; Secondary ion mass spectrometry of environmental particles; Characterization of environmental microparticles; Atmospheric aerosols; Elemental analysis of solids by laser ionization; Speciation analysis in solids by laser mass spectrometry; Laser ionization cluster sources and their applications; Positive Thermal Ions; Negative thermal ions; Geochemical; Nuclear; Nutritional and biomedical; Source and detector instrumentation; Analyzer instrumentation; Environmental applications of accelerator mass spectrometry; Biomedical applications of accelerator mass spectrometry; AMS and extraterrestrial applications; Accelerator mass spectrometry for radiocarbon research; Accelerator mass spectrometry in geophysics and geochemistry; Calutrons and isotope separation; Space exploration; Atmospheric studies by mass spectrometry; Forensic applications of inorganic mass spectrometry; Knudsen cell, high temperature mass spectrometry; Electron impact mass spectrometry of volatile metal chelates; The principles and characteristics of the IRMS instrument; Methods to prepare water as H2 for IRMS measurement of 2H; Continuous-flow isotope ratio mass spectrometry with an elemental analyzer: Oxidative approaches for carbon and nitrogen isotopes; Continuous-flow isotope ratio mass spectrometry with an elemental analyzer: Reductive approaches for hydrogen and oxygen isotopes; Gas Chromatography-Combustion-IRMS (GC-C-IRMS) for Carbon and Nitrogen; Gas Chromatography-Pyrolysis-IRMS (GC-P-IRMS) for Hydrogen and Oxygen; Liquid chromatography (LC) IRMS; Isotope reference materials; Measurement of sulfur isotopes; Variations of abundances of carbon isotopes in nature; Variations of abundances of nitrogen isotopes in nature; Variations of abundances of oxygen isotopes in nature; Variations of abundances of hydrogen isotopes in nature; Thermal ionization MS; ICP-MS; Isotope ratio measurements of atmospheric gases; Use of stable isotope ratio mass spectrometry to detect food adulteration and authenticate origin; Use of isotope effects in forensic analysis of microorganisms; Stable isotope analyses in the study of fish trophodynamics and aquatic food webs; Use of stable isotopes to study climate; Noble gas isotope ratio measurements in space; GC-C-IRMS of 13C; Gas Chromatography-Combustion-Isotope Ratio Mass Spectrometry Applied to Measuring Nitrogen-15 in Biomedicine; Doubly labeled water method to measure free living energy expenditure; Stable isotopes to model water dynamics in living cells; IRMS to detect doping in sports; In vivo calcium metabolism; In vivo trace metal metabolism: iron; In vivo trace metal metabolism: zinc


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© Elsevier Science 2010
Elsevier Science
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About the Series Volume Editor

Diane Beauchemin

Diane Beauchemin

Diane Beauchemin is Professor of Chemistry at Queen's University, Kingsland, Ontario, Canada. Her research efforts are focused on inductively coupled plasma mass spectrometry (ICPMS), aiming to understand the limitations of this technique to identify ways of alleviating them and to expand the range of application of ICPMS (including to speciation analysis and the determination of bio-accessibility). She is considered such an authority that she is regularly invited to write a critical fundamental review on ICPMS by Analytical Chemistry, the analytical journal with the highest impact factor. In addition to these reviews, she has authored over 90 scientific publications, including books and several book chapters. She co-edited Volume 5 of the Encyclopedia of Mass Spectrometry (Elsevier 2010). From 2003 to 2006, she was President of the Canadian Society for Analytical Sciences and Spectroscopy.

Affiliations and Expertise

Department of Chemistry, Queen's University, Kingston, Ontario, Canada

Dwight Matthews

Affiliations and Expertise

The University of Vermont, USA


"The Encyclopedia of Mass Spectrometry, Volume 5: Elemental and isotope ratio mass spectrometry covers the subject almost entirely and serves as a reference work with links to specialist literature if more details are required. Therefore, this book can be recommended to all beginners, students, and experts working in this broad field."--Analytical and Bioanalytical Chemistry