The Detection of Biomarkers
Past, Present, and the Future Prospects
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Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection.
Key Features
- Locates biomarker detection in its research context, setting out present and future prospects
- Allows clinical researchers to compare various biomarker assays systematically
- Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical
- Gives innovative biomarker assays that are viable alternatives to current complex methods
- Helps clinical researchers who need reliable, precise and accurate biomarker detection methods
Readership
Researchers and students in biosensors and biomarkers
Table of Contents
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Chapter 1. Introduction to biomarkers
- Abstract
- 1.1 Introduction
- 1.2 Classification of biomarkers
- 1.3 Biomarker discovery and diagnosis techniques and strategies
- 1.4 Biomarker validation
- 1.5 Biological matrices used for detection
- 1.6 Applications of biomarkers in medicine
- 1.7 Future prospects
- Acknowledgement
- References
- Chapter 2. Low-molecular-weight biomarkers: types and detection strategies
- Abstract
- 2.1 Introduction
- 2.2 Type of low-molecular-weight biomarkers
- 2.3 Low-molecular-weight detection strategies
- 2.4 Bioapplications of low-molecular-weight detection
- 2.5 Conclusion
- References
- Chapter 3. Circulating miRNAs as biomarkers for noninvasive cancer diagnosis
- Abstract
- 3.1 Introduction
- 3.2 An overview of miRNAs
- 3.3 Definition of biosensors
- 3.4 Optical biosensors
- 3.5 Colorimetric biosensors
- 3.6 Fluorescence-based biosensors
- 3.7 Chemiluminescence- and electrochemiluminescent-based biosensors
- 3.8 Surface plasmon resonance-based biosensors
- 3.9 Electrochemical biosensors
- 3.10 Future perspectives
- Acknowledgments
- References
- Chapter 4. Cardiac biomarkers: definition, detection, diagnostic use, and efficiency
- Abstract
- 4.1 Cardiac biomarkers of the acute coronary syndrome
- 4.2 Biomarkers of cardiac failure
- 4.3 Biomarkers of coronary heart disease
- 4.4 Conclusion
- References
- Chapter 5. Proteomic-based identification of novel biomarkers
- Abstract
- 5.1 Introduction
- 5.2 Designing a biomarker discovery study
- 5.3 Methodologies for proteomic-based biomarker discovery studies
- 5.4 The current state of proteomic-based biomarkers
- 5.5 Clinical biomarkers discovered by proteomic approaches
- 5.6 Limitations
- 5.7 Future perspectives
- References
- Chapter 6. Metabolomics tools for biomarker discovery: applications in chronic kidney disease
- Abstract
- 6.1 Introduction
- 6.2 Metabolomics tools for the discovery of novel renal disease biomarkers
- References
- Chapter 7. Electronic devices for biomarker monitoring
- Abstract
- 7.1 Introduction
- 7.2 Biomarkers
- 7.3 Sensing electronic devices: transistors
- 7.4 Conclusion and perspectives
- References
- Chapter 8. Novel advances in nanomaterial-based electrochemical sensing of the biomarker
- Abstract
- 8.1 Introduction
- 8.2 Classification of biomarkers
- 8.3 Various nanomaterials as signal amplification
- 8.4 The novel advance of immobilization strategies for biomarkers
- 8.5 Trends research on electrochemical nano-biosensing of the biomarkers
- 8.6 Conclusion and future perspectives
- References
- Chapter 9. Carbon nanomaterials-based electrochemical cancer biomarkers biosensors
- Abstract
- 9.1 General concepts
- 9.2 Carbon nanostructures-based electrochemical (bio)sensors for the quantification of cancer biomarkers
- 9.3 Conclusions and perspectives
- Acknowledgments
- References
- Chapter 10. Optical nanosensor based on surface-enhanced Raman spectroscopy for biomedical and biomarker detection applications
- Abstract
- 10.1 Introduction
- 10.2 Raman spectroscopy techniques for biomedical applications
- 10.3 Surface-enhanced Raman spectroscopy-based applications in biomarkers
- 10.4 Surface-enhanced Raman spectroscopy applications in bioimaging
- 10.5 Raman activated cell sorting
- 10.6 Surface-enhanced Raman spectroscopy-based microchip system
- 10.7 Surface-enhanced Raman spectroscopy mapping
- 10.8 Conclusions and future prospects
- References
- Chapter 11. Optical smartphone-based sensing: diagnostic of biomarkers
- Abstract
- 11.1 Introduction
- 11.2 Optical smartphone-based biosensors for the detection of biomarkers
- 11.3 Summary and future perspectives
- Acknowledgments
- References
- Chapter 12. Design of immunosensors for rapid and sensitive detection of biomarkers
- Abstract
- 12.1 Immunosensor
- 12.2 Biomarkers and their classification
- 12.3 Antibodies and their immobilization methods
- 12.4 Immunosensor formats
- 12.5 Applications of nanomaterials to amplify the analytical signal of immunosensors
- 12.6 Transducers used for immunosensors
- 12.7 Multiplexed assay–based immunosensors for biomarkers detection
- 12.8 Conclusions and future outlook
- Acknowledgments
- References
- Chapter 13. Recent advances in immunosensors for healthcare
- Abstract
- 13.1 Introduction
- 13.2 Immunosensors for healthcare
- 13.3 Summary and outlooks
- References
- Chapter 14. Impedimetric immunosensors for detection of biomarkers
- Abstract
- 14.1 Introduction
- 14.2 Conclusion and future remarks
- References
- Chapter 15. Conducting polymers—versatile tools in analytical systems for the determination of biomarkers and biologically active compounds
- Abstract
- 15.1 Introduction
- 15.2 Conclusions
- Funding
- Conflicts of interest
- References
- Chapter 16. Molecularly imprinted biosensors for sensitive detection of biomarkers
- Abstract
- 16.1 Introduction
- 16.2 Biomarkers
- 16.3 Molecularly imprinting technology
- 16.4 Surface imprinting
- 16.5 Electrochemical transduction
- 16.6 Voltammetry/amperometry
- 16.7 Potentiometry
- 16.8 Capacitance/impedance
- 16.9 Optical sensors
- 16.10 Piezoelectric sensors
- 16.11 Conclusion
- References
- Chapter 17. Microfluidics technology: past, present, and future prospects for biomarker diagnostics
- Abstract
- 17.1 General introduction
- 17.2 Type of microfluidics system
- 17.3 Application of microfluidic system
- 17.4 Future and perspectives
- References
- Chapter 18. Wearable biosensors for monitoring of disease-related biomarkers
- Abstract
- 18.1 Introduction
- 18.2 Wearable (bio)devices for monitoring of disease biomarkers
- 18.3 Wearable optical (bio)sensors
- 18.4 Wearable electrochemical biosensors
- 18.5 Opportunities, challenges, concerns, and future prospects
- Acknowledgments
- References
- Chapter 19. Nanomachines and nanorobotics: improving cancer diagnosis and therapy
- Abstract
- 19.1 Introduction
- 19.2 Nanomachines at a glance
- 19.3 Nanodevices in cancer diagnosis and imaging
- 19.4 Nanomachines in active cancer drugs delivery
- 19.5 Nanomachines and nanorobots for cancer theragnostic
- 19.6 Nanosurgery
- 19.7 Conclusion and future prospects
- Acknowledgments
- References
- Chapter 20. Analytical perspective on biomarkers research: from untargeted to targeted metabolomics
- Abstract
- 20.1 Introduction
- 20.2 Krebs cycle targeted pathway analysis
- 20.3 Sulfur pathway
- 20.4 Phosphonucleotides
- 20.5 Validation of targeted metabolomic analysis
- 20.6 Conclusion
- References
- Index
Product details
- No. of pages: 614
- Language: English
- Copyright: © Academic Press 2021
- Published: December 5, 2021
- Imprint: Academic Press
- Paperback ISBN: 9780128228593
- eBook ISBN: 9780128230756
About the Editors
Sibel Ozkan
Prof. Dr. Sibel A. Ozkan is a Full Professor in the Faculty of Pharmacy at Ankara University. She has over 30 years of experience in analytical chemistry. She has established expertise in electrochemistry, validation, electrochemical biosensors, DNA biosensors, enzyme biosensors, biomarkers, drug analysis from biological samples or dosage forms, liquid chromatography, capillary electrophoresis, spectrophotometry. She has won Encouragement Award from Ankara University in 2003, Science Award from Turkish Pharmacists Association in 2008, and The Best Ph.D. Thesis in Turkey Award 2017 (Health Sciences), High Council of Education of Turkey, Ton Duc Thang University “Woman in Science 2019” Prize, 27 December 2019, Ankara University Science Support Award, 2020.
Affiliations and Expertise
Ankara University, Turkey
Nurgul Bakirhan
Nurgul K. Bakirhan is an Associated Professor at the Department of Analytical Chemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Turkey. She received her doctorate from the Faculty of Pharmacy at Ankara University in Turkey. She was visiting researcher at the Université libre de Bruxelles with TUBITAK 2214 fellowship during six months. Her research interests include sensors, nanomaterials, conductive polymers, electrochemical impedance spectroscopy and electrochemical investigations on active pharmaceutical compounds, validation. She has published over 60 papers and 10 book chapters.
Affiliations and Expertise
Associated Professor at the Department of Analytical Chemistry, Gulhane Faculty of Pharmacy, University of Health Sciences, Turkey
Fariba Mollarasouli
Fariba Mollarasouli is an Assistant Professor in the Department of Chemistry at Yasouj University, Yasouj, Iran. Her areas of research and expertise include analytical and bioanalytical method development, drug analysis, electrochemical sensors and biosensors, immunosensors, as well as the development of various nanomaterials (design, synthesis, characterization, and applications) for fabricating nanosensors with clinical and environmental applications.
Affiliations and Expertise
Assistant Professor in the Department of Chemistry at Yasouj University, Yasouj, Iran