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The Design and Development of Novel Drugs and Vaccines: Principles and Protocols presents both in silico methods and experimental protocols for vaccine and drug design and develo… Read more
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Researchers and advanced students in life sciences, pharmacology, chemistry, biochemistry, toxicology and pharmaceutical science
1. Introduction of structural bioinformatics with respect to drug discovery
2. Target identification and validation
3. Retrieval of compounds
4. Lead identification and optimization
5. Molecular dynamics simulations
6. An overview of vaccine design
7. Key steps in the selection of vaccine targets
8. Epitope prediction and selection of linkers and adjuvant
9. Design of vaccine constructs
10. In-silico validation through protein-protein docking
11. Molecular cloning
12. Protein expression
13. Protein purification and desalting
14. Biological assay
15. Biophysical methods
16. Outline of animal study for lead/ vaccine testing
17. Evaluation of immunogenicity of vaccine candidate
18. In-vitro evaluation of lead molecule
19. Medical physiological parameter for lead/vaccine testing
20. Brief introduction of clinical research and trials
21. An overview of IND, NDA, approval agencies and FDA post-marketing surveillance
22. Introduction of Intellectual property rights
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