2. The Complement Proteins
C1q and the Collectins
Terminal Pathway Components
Regulations of Complement Activation (RCA)
Cell Surface Receptors
Miscellaneous Complement Components
The Complement FactsBook, Second Edition, provides in-depth insights and an overview of the components of the complement system. This new edition highlights the use of newly recommended complement nomenclature, covering new pathways and proteins and adding information on mouse homologs. It is a completely revised and updated edition containing entries on all components of the complement system, and is an excellent source of one-stop shopping for complement information and references. It is the most convenient compilation of biochemical, biological and molecular biology for complementologists and those new in the field.
This new edition is expanded to include relevant updates and topics that have evolved since the last edition was published, including C1q and Lectins, C3 Family, Serine Proteases, Serum Regulators of Complement Activation, Cell Surface Proteins, and Terminal Pathway Proteins. Domain Structure diagrams are incorporated to clearly illustrate the relationships between all the complement proteins, both within families and between families.
- Introduces complement function, simply described for each function
- Includes the cDNA sequences that are marked with intron/exon boundaries, facilitating genetic studies
- Presents detailed structural information, including cDNA and gene structure for all proteins
- Incorporates domain structures diagrams, which beautifully illustrate the relationship between all the complement proteins, both within, and between, families
Basic researchers and clinicians in immunology, biochemistry, cell biology, and infectious diseases; scientists in pharmaceutical and biotech companies, anyone interested in the complement system. More recently investors and market analysts have become interested in complement because of the growing complement therapeutics market
- No. of pages:
- © Academic Press 2018
- 19th October 2017
- Academic Press
- eBook ISBN:
- Paperback ISBN:
Theresa Schein received her B.S. in Biology (cum laude) from the University of South Carolina, Aiken where she studied HIV and molecular cloning. Dr. Schein then attended the University of Alabama at Birmingham where she earned her Ph.D. on the role of complement in the development and progression of cerebral malaria. Publishing numerous manuscripts on the role of complement components in experimental cerebral malaria, her studies were seminal in establishing the therapeutic potential of inhibiting the complement terminal pathway in this infectious disease. Upon graduation, she received the Dean’s Outstanding Student Award, among others. She then pursued a short postdoctoral study on the role of the terminal complement pathway in amyotrophic lateral sclerosis at UAB, before transitioning to an entrepreneurial role in a small startup out of St. Louis. While her collaborative efforts have spanned her complement research from infectious to autoimmune disease as demonstrated by her publishing record, Dr. Ramos is currently working on the development of complement centric diagnostics for use in bacterial meningitis.
Research Scientist, Department of Microbiology, University of Alabama at Birmingham, Alabama, USA