The Cholesterol Wars

The Cholesterol Wars

The Skeptics vs the Preponderance of Evidence

1st Edition - September 10, 2007

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  • Editor: Daniel Steinberg
  • Hardcover ISBN: 9780123739797
  • eBook ISBN: 9780080556192

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Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. The Cholesterol Wars chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.

Key Features

  • Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community
  • Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs
  • Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis


Biochemists, cardiologists, pharmacologists, researchers in lipid and lipoprotein metabolism, and researchers in vascular disease

Table of Contents

  • Thoughts on the Nature of Medical Controversy in General and an Overview of the Cholesterol Controversy in Particular
    Animal Models of Atherosclerosis
    Early Evidence Linking Hypercholesterolemia to Atherosclerosis and Coronary Heart Disease
    Lipoproteins and Metabolism
    In Search of a Pathogenesis
    Basic Science Foundations
    Searching for Drugs that would Lower Blood Cholesterol Safely and Effectively
    1984 Coronary Primary Prevention Trial
    A Look at the Future

Product details

  • No. of pages: 248
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: September 10, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123739797
  • eBook ISBN: 9780080556192

About the Editor

Daniel Steinberg

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