The Cholesterol Wars

1st Edition

The Skeptics vs the Preponderance of Evidence

Editors: Daniel Steinberg
Hardcover ISBN: 9780123739797
eBook ISBN: 9780080556192
Imprint: Academic Press
Published Date: 10th September 2007
Page Count: 248
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Description

Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.

Key Features

  • Dr. Steinberg and his colleagues have published over 400 papers relating to lipid and lipoprotein metabolism and atherosclerosis reflecting the prominence these authors have in the community.
  • Chronicles the miraculous power of the statins to prevent heart attacks and save lives, of great interest to the many manufacturers of these drugs
  • Discusses new targets for intervention based on a better understanding of the molecular basis of atherosclerosis

Readership

Biochemists, cardiologists, pharmacologists, researchers in lipid and lipoprotein metabolism, and researchers in vascular disease

Table of Contents

Thoughts on the Nature of Medical Controversy in General and an Overview of the Cholesterol Controversy in Particular Animal Models of Atherosclerosis Early Evidence Linking Hypercholesterolemia to Atherosclerosis and Coronary Heart Disease Lipoproteins and Metabolism In Search of a Pathogenesis Basic Science Foundations Searching for Drugs that would Lower Blood Cholesterol Safely and Effectively 1984 Coronary Primary Prevention Trial Statins A Look at the Future

Details

No. of pages:
248
Language:
English
Copyright:
© Academic Press 2007
Published:
Imprint:
Academic Press
eBook ISBN:
9780080556192
Hardcover ISBN:
9780123739797

About the Editor

Daniel Steinberg

Reviews

Today, in the era of the statins (cholesterol lowering drugs), there is no longer any doubt about the value of lowering blood cholesterol levels. This book chronicles the controversy that swirled around the 'lipid hypothesis' of atherosclerosis for so many years. In fact, 'the lower the better' is the position of many clinicians. However, getting to this point has been a long uphill battle marked by heated debate and sometimes violent disagreement. The history of this controversy is told here for its own sake and because remembering it may help us avoid similar mistakes in the future.