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The Catecholamines in Psychiatric and Neurologic Disorders focuses on the contributions of catecholamines (CA) in the modulation of blood pressure, stress and exercise, body movements, memory, learning, emotions, thought processing, appetite, and mediation of psychotropic drug action.
The selection first elaborates on the techniques for the assessment and interpretation of catecholamine measurements in neuropsychiatric patients and catecholaminergic response to stress and exercise. Discussions focus on noradrenergic response to isometric exercise, isotonic exercise, effect of acceleration on sympathetic activity, techniques for sympathetic nervous system evaluation, and measurements of CA and their metabolites in cerebrospinal fluid.
The text then takes a look at urinary CA in behavioral research on stress; CA in anxiety disorders and mitral valve prolapse; and interaction with neurotransmitters in normal subjects and in patients with selected neurologic diseases. The selection examines noradrenergic responses in postural hypotension, norepinephrine, alcohol, and alcoholism, and catecholamine metabolism in anorexia nervosa. Topics include cerebral catecholamine metabolism in anorexia nervosa; central nervous system norepinephrine and voluntary alcohol drinking; and overview of norepinephrine in selected pediatric disorders.
The book is a dependable reference for neuropsychiatrists and readers interested in the contributions of catecholamines on psychiatric disorders.
1. Techniques for the Assessment and Interpretation of Catecholamine Measurements in Neuropsychiatric Patients
Catecholamine Assay Techniques
Techniques for Sympathetic Nervous System Evaluation
The Neurologic Basis for Changes in Plasma Catecholamines
Measurements of Catecholamines and Their Metabolites in Cerebrospinal Fluid
Cerebrospinal Fluid Catecholamines in Some Neuropsychiatric Diseases
2. The Catecholaminergic Response to Stress and Exercise
Age and Sympathetic Activity
Effect of Acceleration on Sympathetic Activity
Sympathetic Response to Acceleration Greater than 1G
The Noradrenergic Response to Isometric Exercise
3. Urinary Catecholamines in Behavioral Research on Stress
Relationship Between Epinephrine and Norepinephrine
Methodologic Aspects of Catecholamine Assessment
Consistency in Catecholamine Excretion
Factors Affecting Catecholamine Excretion
Catecholamines and Health
II. Neuropsychiatric Disorders
4. Catecholamines in Anxiety Disorders and Mitral Valve Prolapse
Catecholamines in Anxiety Disorders
Mitral Valve Prolapse
5. Central Catecholamine Systems: Interaction with Neurotransmitters in Normal Subjects and in Patients with Selected Neurologic Diseases
Neurotransmitters Related to Norepinephrine in the Basal Ganglia
Interaction of Dopamine and Norepinephrine
Neurochemical Changes in Clinical Conditions
6. Noradrenergic Responses in Postural Hypotension: Implications for Therapy
Mechanisms of Postural Blood Pressure Maintenance
Diagnosis of the Systemic Defect Causing Postural Hypotension
Postural Hypotension in Diabetics
Therapy of Postural Hypotension
Approach to the Patient with Postural Hypotension
7. Norepinephrine, Alcohol, and Alcoholism
Effects of Alcohol on Brain Norepinephrine
Central Nervous System Norepinephrine and Voluntary Alcohol Drinking
8. Catecholamine Metabolism in Anorexia Nervosa
Peripheral Catecholamine Metabolism in Anorexia Nervosa
Cerebral Catecholamine Metabolism in Anorexia Nervosa
III. Pediatric Disorders and the Catecholamines
9. Overview of Norepinephrine in Selected Pediatric Disorders
Childhood Schizophrenia and Infantile Autism
Gilles de la Tourette's Syndrome
Dystonia Musculorum Deformans
Duchenne Type Muscular Dystrophy
10. Catecholamine Metabolism in Hyperactive Children
Direct Biochemical Studies
Pharmacologie, Clinical, and Biochemical Responses
IV. Affective Disorders and the Catecholamines
11. Norepinephrine in the Affective Disorders: Classic Biochemical Approaches
Clinical Studies Antedating Measures of Norepinephrine
Clinical Studies of Norepinephrine
12. Norepinephrine in the Affective Disorders: Receptor Assessment Strategies
Tissue Receptor Studies
Implications of Receptor Studies for Models of Noradrenergic Regulation in the Affective Disorders
Noradrenergic Receptor Changes Accompanying Antidepressant Treatment
13. Parkinsonism and Depression: Dopaminergic Mediation of Neuropathologic Processes in Human Beings
Mood Modulation by Drugs That Alter Central Dopamine Activity
Parkinson's Disease: Biochemistry and Treatment
Cognitive Function Modified by Depression, Parkinsonism, and Dopamine Agonists
V. Schizophrenia and the Catecholamines
14. Studies of Norepinephrine in Schizophrenia
15. Studies of the Dopamine Hypothesis of Schizophrenia
Presynaptic Dopaminergic Mechanisms
Postsynaptic Dopaminergic Mechanisms
- No. of pages:
- © Butterworth-Heinemann 1985
- 15th March 1985
- eBook ISBN:
Dr. Lake graduated with BS and MS degrees in Zoology from Tulane University, New Orleans, LA, in 1965 and 1966. He graduated from Duke University in Durham, NC, School of Medicine with an MD and from the Duke Graduate School (Department of Physiology and Pharmacology) with a Ph.D., in 1971 and 1972. He studied at Oxford University and at St. Bartholomew’s Hospital, London. His residency in Psychiatry was completed at Duke and at the National Institute of Mental Health (NIMH), Bethesda, MD. At Duke he was taught and continues to practice individual, couples and group psychotherapy. At the NIMH, he was privileged to collaborate with and learn about bipolar from Drs. Fred Goodwin, Bob Post, Dennis Murphy, Julie Axelrod and Irv Kopin. He remained in the Laboratory of Clinical Sciences as a research associate, then staff psychiatrist until 1980 when he moved “across the Pike” to take a professorship of Psychiatry and Pharmacology at the then new Uniformed Services University of the Health Sciences (USUHS), School of Medicine, Bethesda, MD. He secured two NIH RO1’s, continuing his research on the regulation of the sympathetic nervous system in health and in patients with neuropsychiatric and cardiovascular disorders. He taught medical students and residents in Psychiatry while following patients in his office and clinics. In 1993 he accepted the Chairmanship of Psychiatry at the University of Kansas, School of Medicine, Kansas City, Kansas, and remained Chair for three years after which he continued as Professor on the full-time faculty until his recent partial retirement. As Professor Emeritus he continues to publish about Mood Disorders and to follow his long-term Bipolar patients. Dr. Lake has over 250 journal publications including in Science, Nature, NEJM, AJP and AGP. His book titled Schizophrenia is a Misdiagnosis was published by Springer in 2012. He has achieved distinguished life-fellowship status in the American Psychiatric Association and the American College of Neuropsychopharmacology.
Professor Emeritus, Department of Psychiatry and Behavioral Sciences, University of Kansas School of Medicine, Kansas City, KS, USA
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