The current volume focuses on several key aspects of mind/brain/body interactions in health and disease, including specific examples of interactions between body and brain, mechanisms underlying the response of the system to stressors, the role of early life events in permanently biasing the responsiveness of the system and practical implications of mind body interactions in human disease.

The volume on Biological Basis for Mind Body Interactions is organized into 6 major sections, each dealing with a unique aspect of the general topic: After establishing the relationship between mind, brain and emotions, the first section deals with general neurobiological aspects mediating the effect of stress on various organ systems, including the immune and cardiovascular system. The second section covers the topic of how early life stressor can permanently alter responsiveness of the nervous system in animals and in man. The third section deals with influences of the internal environment, mediated by neuroendocrine and visceral afferent pathways on the CNS. The fourth section which deals with influences of body on the brain, focuses on mechanisms involved in perception and modulation of pain. The fifth section deals with influences of the mind/brain on the body, with an emphasis on central and peripheral mechanisms of autonomic control of body functions. The last section deals with a series of practical issues of mind body treatments, including acupuncture, breathing, body work and meditation. In addition, issues such as cost effectiveness and research aspects are discussed. Authors in this last section frequently refer to topics and mechanisms addressed in the early sections, making it a truly integrated volume.

The unique aspect of the volume is the integration of state of the art research information on biological and practical aspects of mind/brain/body interactions. It is based on the beliefs of the editors and participants that the traditional separation

Table of Contents

List of Contributors. Preface. Acknowledgements. Section I. Introduction 1. Minding the mind (E.A. Mayer, C.B. Saper). Section II. Relationship between mind, brain and emotions. 2. Topography and relationships of mind and brain (B.A. Vogt, O. Devinsky). Section III. The neurobiology of the stress response. 3. Protective and damaging effects of stress mediators: central role of the brain (B.S. McEwen). 4. Interactions between the immune and neuroendocrine systems (E.M. Sternberg). 5. Depression really does hurt your heart: stress, depression and cardiovascular disease (D.L. Musselman, C.B. Nemeroff). 6. Circuits and mechanisms governing hypothalamic responses to stress: a tale of two paradigms (P.E. Sawchenko, H.-Y. Li, A. Ericsson). Section IV. Early life experiences and the developing brain. 7. Long-term behavioral and neuroendocrine adaptations to adverse early experience (C.O. Ladd, R.L. Huot, K.V. Thrivikraman, C.B. Nemeroff, M.J. Meaney, P.M. Plotsky). 8. Neurobiological correlates of defensive behaviors (V.P. Bakshi, S.E. Shelton, N.H. Kalin). 9. Effects of perinatal pain and stress (K.J.S. Anand). 10. Early life abuses in the past history of patients with gastrointestinal tract and pelvic floor dysfunctions (G. Devroede). Section V. Influences of the internal environment on the brain. 11. Responses of afferent neurons to the contents of the digestive tract, and their relation to endocrine and immune responses (J.P. Furness, N. Clerc). 12. The controls of eating: brain meanings of food stimuli (G.P. Smith). 13. Effects of nutrients on brain function (T.J. Maher). 14. The evolving neurobiology of gut feelings (E.A. Mayer, B. Naliboff, J. Munakata). Section VI. Influences of the body on the brain. 15. Integration of viscerosomatic sensory input at the spinal level (R.D. Foreman). 16. The medial pain system, cingulate cortex, and parallel processing of nociceptiv


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© 2000
Elsevier Science
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About the editors

E.A. Mayer

Affiliations and Expertise

UCLA/CURE Neuroenteric Disease Program, West Los Angeles VA Medical Center, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA

C.B. Saper

Affiliations and Expertise

Department of Neurology, Beth Israel Hospital, 330 Brookline Avenue, Boston, MA 02215, USA


@from:(K.V. Slavin, MD, University of Illinois at Chicago College of Medicine) @qu:(...)Both researchers and clinicians will find information from this volume interesting and stimulating. Written by specialists from six countries, it may serve as a current, up-to-date reference source on the title subject.
An attractive feature of this volume is the wide spectrum of topics covered(...)The book is well illustrated; all chapters are well referenced; the index is large and complete.
With this new volume in the series Progress in Brain Research, the editors give an idea of the current state of research in the area of brain/mind and body interactions. Most neuroscientists, clinicians, and researchers will find plenty of new information, thorough reviews, and original data(...) @source:Doody's Electronic Journal