The Antiphospholipid Syndrome II

1st Edition

Autoimmune Thrombosis

Print ISBN: 9780444549914
eBook ISBN: 9780080527307
Imprint: Elsevier Science
Published Date: 22nd August 2002
Page Count: 478
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This book provides the reader with a comprehensive overview of the Antiphospholipid syndrome. One of the most important advances in rheumatology and connective tissue diseases of the last decade. It provides an explanation for many previously undefined conditions with no clear pathogenesis encompassing all subspeculations in internal medicine as well as obstetrics. Clotting problems leading to strokes and myocardial infarctions (in younger people) as well as a large variety of other syndromes such as chorea, hyproadrenalism, pulmonary problems are now being understood.

Table of Contents

Preface. Editor biography. List of Contributors. I. History and Epidemiology of the Antiphospholipid Syndrome (R.A. Asherson). Milestones in the Antiphospholipid Syndrome (R.A. Asherson et al.). Classification and Epidemiology of the Antiphospholipid Syndrome (M. Petri). II. Immunology and Pathophysiology of the Antiphospholipid Syndrome (Y. Shoenfeld). Lupus Anticoagulant: Detection, Standardization and Heterogeneity (D.A. Triplett, M.-C. Boffa). Antibodies to Cardiolipin and other Phospholipids (S.S. Pierangeli, E.N. Harris). &bgr;2-Glycoprotein I and anti-&bgr;2-Glycoprotein I Antibodies (P.G. De Groot et al.). Anti-Prothrombin Antibodies (M. Galli). The Annexins: A Target of Antiphospholipid Antibodies (J.H. Rand, Xiao-Xuan Wu). Antiphospholipid/Endothelial Cell Interaction in the Pathogenesis of the Antiphospholipid Syndrome (P.L. Luigi et al.). Tissue Factor, Protein C pathway and other Hemostasis Abnormalities in the Pathogenesis of the Antiphospholipid Syndrome (R.A.S. Roubey). Systemic Involvement in the Antiphospholipid Syndrome: Lessons from Animal Models (Y. Shoenfeld et al.). Cytokines, Th1/Th2 and Adhesion Molecules in the Antiphospholipid Syndrome (M. Ehrenfeld et al.). Lessons from Monoclonal Antiphospholipid Antibodies (M. Abu-Shakra, Y. Shoenfeld). Immunogenetics of the Antiphospholipid Syndrome (G.D. Sebastiani et al.). Pathology of the Antiphospholipid Syndrome (E. Reyes, D. Alarcón-Segovia). Antiphospholipid Antibodies in Human and Murine Atherogenesis (Y. Sherer, Y. Shoenfeld). III. Clinical Features in the Antiphospholipid Syndrome (R. Cervera). Thrombotic Manifestations in the Antiphospholipid Syndrome (J.O. Ros et al.). Neurologic Manifestations in the Antiphospholipid Syndrome (R.L. Brey et al.). Cardiac and Pulmonary Manifestations in the Antiphospholipid Syndrome (G. Espinosa


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© Elsevier Science 2002
Elsevier Science
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@from:M. Bijl, G.C.M. Kallenberg a very valuable source for those who want to have an overview of the great progress which has been made in fundamental research, the increasing pathophysiological insights and the current treatment modalities in APS. It is particularly useful for researchers and of value for clinicians dealing with patients with APS and the various disease manifestations these patients can develop. @source:Annals of the Rheumatic Diseases