The Antigens
Volume VII
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The Antigens, Volume VII is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Different aspects of the genetic control of the immune response are explored, along with the link between infection and autoimmunity. Comprised of four chapters, this volume begins with a discussion on the determinant-specific genetic regulation of the immune response and the genes that control it. The next chapter deals with the molecular genetics and polymorphism of of class II (Ia) antigens, as well as the correlation between immunogenetic and molecular genetic maps. The antigen-specific T cell clones and the specific factors derived from them are then examined. The last chapter considers the relationship between infection and autoimmunity; the role of infection in the expression of class II antigens; and processes responsible for the induction of autoimmune diseases. A specific therapy for these diseases is described. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.
Table of Contents
List of Contributors
Preface
Contents of Other Volumes
Chapter 1 Ir Genes: Antigen-Specific Genetic Regulation of the Immune Response
I. Introduction/Definitions
II. Developing Concepts
III. The Role of Genetic Restriction of Cell Interactions in Ir Gene Function
IV. Levels of Imposition of Genetic Restriction; Role of the Thymic Environment; Studies in Chimeras
V. Ia Antigens as Ir Gene Products
VI. Non-MHC-Linked Ir Genes
VII. The Role of Suppressor Cells in Ir Gene Control
VIII. The T Cell Repertoire Model
IX. The Antigen Presentation Model
X. T Cell Influences on Antibody Specificity
XI. Epilogue
References
Chapter 2 Molecular Genetics of Class II (Ia) Antigens
I. Introduction
II. Immunogenetics
III. Genomic Organization of the I Region
IV. Correlation of Immunogenetic and Molecular Genetic Maps
V. Gene Organization
VI. Polymorphism of Class II Antigens
VII. Correlation Between Structure and Function of Class II Antigens
VIII. Regulation of Ia Expression
IX. Conclusion
References
Chapter 3 Antigen-Specific T Cell Clones and T Cell Factors
I. Introduction
II. Functional T Cell Hybridomas and Their Soluble Products
III. Antigen-Specific Virus-Transformed Functional T Cell Lines
IV. T Cell Continuous Lines and Clones
V. The T Cell Receptor
VI. Concluding Remarks
References
Chapter 4 Infection and Autoimmunity
I. Introduction
II. Molecular Mimicry Between Microbial and Host Antigens
III. Autoantibodies Produced by Patients with Infections
IV. Altered Self
V. Polyclonal Activation
VI. The Role of Infection in the Expression of HLA Class II Antigens in Self Tissues
VII. The Anti-Idiotypic Network
VIII. Specific Therapy of Autoimmune Disease
References
Index
Product details
- No. of pages: 368
- Language: English
- Copyright: © Academic Press 1987
- Published: December 11, 1987
- Imprint: Academic Press
- eBook ISBN: 9781483269665