The Antigens

The Antigens

Volume VII

1st Edition - December 11, 1987

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  • Editor: Michael Sela
  • eBook ISBN: 9781483269665

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The Antigens, Volume VII is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Different aspects of the genetic control of the immune response are explored, along with the link between infection and autoimmunity. Comprised of four chapters, this volume begins with a discussion on the determinant-specific genetic regulation of the immune response and the genes that control it. The next chapter deals with the molecular genetics and polymorphism of of class II (Ia) antigens, as well as the correlation between immunogenetic and molecular genetic maps. The antigen-specific T cell clones and the specific factors derived from them are then examined. The last chapter considers the relationship between infection and autoimmunity; the role of infection in the expression of class II antigens; and processes responsible for the induction of autoimmune diseases. A specific therapy for these diseases is described. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    Chapter 1 Ir Genes: Antigen-Specific Genetic Regulation of the Immune Response

    I. Introduction/Definitions

    II. Developing Concepts

    III. The Role of Genetic Restriction of Cell Interactions in Ir Gene Function

    IV. Levels of Imposition of Genetic Restriction; Role of the Thymic Environment; Studies in Chimeras

    V. Ia Antigens as Ir Gene Products

    VI. Non-MHC-Linked Ir Genes

    VII. The Role of Suppressor Cells in Ir Gene Control

    VIII. The T Cell Repertoire Model

    IX. The Antigen Presentation Model

    X. T Cell Influences on Antibody Specificity

    XI. Epilogue


    Chapter 2 Molecular Genetics of Class II (Ia) Antigens

    I. Introduction

    II. Immunogenetics

    III. Genomic Organization of the I Region

    IV. Correlation of Immunogenetic and Molecular Genetic Maps

    V. Gene Organization

    VI. Polymorphism of Class II Antigens

    VII. Correlation Between Structure and Function of Class II Antigens

    VIII. Regulation of Ia Expression

    IX. Conclusion


    Chapter 3 Antigen-Specific T Cell Clones and T Cell Factors

    I. Introduction

    II. Functional T Cell Hybridomas and Their Soluble Products

    III. Antigen-Specific Virus-Transformed Functional T Cell Lines

    IV. T Cell Continuous Lines and Clones

    V. The T Cell Receptor

    VI. Concluding Remarks


    Chapter 4 Infection and Autoimmunity

    I. Introduction

    II. Molecular Mimicry Between Microbial and Host Antigens

    III. Autoantibodies Produced by Patients with Infections

    IV. Altered Self

    V. Polyclonal Activation

    VI. The Role of Infection in the Expression of HLA Class II Antigens in Self Tissues

    VII. The Anti-Idiotypic Network

    VIII. Specific Therapy of Autoimmune Disease



Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © Academic Press 1987
  • Published: December 11, 1987
  • Imprint: Academic Press
  • eBook ISBN: 9781483269665

About the Editor

Michael Sela

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