The Antigens - 1st Edition - ISBN: 9780126355079, 9781483269665

The Antigens

1st Edition

Volume VII

Editors: Michael Sela
eBook ISBN: 9781483269665
Imprint: Academic Press
Published Date: 11th December 1987
Page Count: 368
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Description

The Antigens, Volume VII is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Different aspects of the genetic control of the immune response are explored, along with the link between infection and autoimmunity.

Comprised of four chapters, this volume begins with a discussion on the determinant-specific genetic regulation of the immune response and the genes that control it. The next chapter deals with the molecular genetics and polymorphism of of class II (Ia) antigens, as well as the correlation between immunogenetic and molecular genetic maps. The antigen-specific T cell clones and the specific factors derived from them are then examined. The last chapter considers the relationship between infection and autoimmunity; the role of infection in the expression of class II antigens; and processes responsible for the induction of autoimmune diseases. A specific therapy for these diseases is described.

This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Table of Contents


List of Contributors

Preface

Contents of Other Volumes

Chapter 1 Ir Genes: Antigen-Specific Genetic Regulation of the Immune Response

I. Introduction/Definitions

II. Developing Concepts

III. The Role of Genetic Restriction of Cell Interactions in Ir Gene Function

IV. Levels of Imposition of Genetic Restriction; Role of the Thymic Environment; Studies in Chimeras

V. Ia Antigens as Ir Gene Products

VI. Non-MHC-Linked Ir Genes

VII. The Role of Suppressor Cells in Ir Gene Control

VIII. The T Cell Repertoire Model

IX. The Antigen Presentation Model

X. T Cell Influences on Antibody Specificity

XI. Epilogue

References

Chapter 2 Molecular Genetics of Class II (Ia) Antigens

I. Introduction

II. Immunogenetics

III. Genomic Organization of the I Region

IV. Correlation of Immunogenetic and Molecular Genetic Maps

V. Gene Organization

VI. Polymorphism of Class II Antigens

VII. Correlation Between Structure and Function of Class II Antigens

VIII. Regulation of Ia Expression

IX. Conclusion

References

Chapter 3 Antigen-Specific T Cell Clones and T Cell Factors

I. Introduction

II. Functional T Cell Hybridomas and Their Soluble Products

III. Antigen-Specific Virus-Transformed Functional T Cell Lines

IV. T Cell Continuous Lines and Clones

V. The T Cell Receptor

VI. Concluding Remarks

References

Chapter 4 Infection and Autoimmunity

I. Introduction

II. Molecular Mimicry Between Microbial and Host Antigens

III. Autoantibodies Produced by Patients with Infections

IV. Altered Self

V. Polyclonal Activation

VI. The Role of Infection in the Expression of HLA Class II Antigens in Self Tissues

VII. The Anti-Idiotypic Network

VIII. Specific Therapy of Autoimmune Disease

References

Index

Details

No. of pages:
368
Language:
English
Copyright:
© Academic Press 1987
Published:
Imprint:
Academic Press
eBook ISBN:
9781483269665

About the Editor

Michael Sela