The Antigens

The Antigens

Volume VI

1st Edition - January 28, 1982

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  • Editor: Michael Sela
  • eBook ISBN: 9781483269580

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The Antigens, Volume VI is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Parasite antigens and their immunogenicity in infected hosts are explored, along with the nature of the antibody-combining site and the phenomenon of immunological tolerance. Comprised of three chapters, this volume begins with a discussion on the dynamic aspects of the function of antibodies, paying particular attention to the structure of immunoglobulins and the folding of their domains; the dynamics of segmental flexibility; the kinetics of antibody-hapten association and the kinetic expression of elementary interaction; and the conformational transitions within the antibody molecule induced by hapten binding. The next chapter focuses on the immunogenicity of parasite antigens in infected hosts, citing such parasites as trypanosomes, Schistosoma mansoni, and Fasciola hepatica. The last chapter deals with immunological tolerance, its induction and duration, and its effect on the specificity of the immune response. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    Chapter 1 Dynamic Aspects of Antibody Function

    I. Introduction

    II. Structure of Immunoglobulins

    III. Folding of Immunoglobulin Domains

    IV. The Association between Domains and Chains

    V. Dynamics of Segmental Flexibility

    VI. Kinetics of Antibody-Hapten Association

    VII. Kinetic Expression of Elementary Interactions

    VIII. Conformational Transitions Induced by Hapten Binding


    Chapter 2 Parasite Antigens and Their Immunogencity in Infected Hosts

    I. Introduction

    II. Classification of Parasite Antigens

    III. Accessibility of Parasite Antigens

    IV. Some Parasite Antigens and Antigenic Preparations with Proved Immunoparasitological Unity and for Which Some Immunochemical Information Is Available

    V. Concluding Comment: Parasite Immunochemistry in the Early 1980's


    Chapter 3 Immunological Tolerance

    I. Introduction

    II. General Methodology

    III. Tolerance Induction

    IV. Tolerance Duration

    V. The Effect of Tolerance on the Specificity of the Immune Response

    VI. Tolerance at the Cellular Level

    VII. Mechanism and Molecular Basis of Unresponsiveness—Pathways of Inhibition

    VIII. Split Tolerance

    IX. The Effect of External Agents on Tolerance Induction

    X. Cellular Aspects of Tolerance Circumvention

    XI. Tolerance and Immunity to Autologous Molecules

    XII. Barriers against Destruction of the Fetus

    XIII. Animal Models for Autoimmunity

    XIV. Autoimmune Disease

    XV. Tolerance as a Potential Tool for Heterotransplantation

    XVI. Concluding Remarks


    Author Index

    Subject Index

Product details

  • No. of pages: 568
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 28, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9781483269580

About the Editor

Michael Sela

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