The Antigens - 1st Edition - ISBN: 9780126355055, 9781483269573

The Antigens

1st Edition

Volume V

Editors: Michael Sela
eBook ISBN: 9781483269573
Imprint: Academic Press
Published Date: 28th August 1979
Page Count: 424
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The Antigens, Volume V is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Four complex problems of direct relevance to human health are explored, namely, tumor antigens, antigens of helminths, cytotoxic lymphocytes, and complement.

Comprised of four chapters, this volume begins with a review of classic studies of tumor-specific transplantation antigens, followed by a discussion on the detection and purification of tumor antigens; the immune response to tumor antigens; and the role of tumor antigens in the escape of tumors from immunological control. The reader is then introduced to some aspects of the different functions of antigens of helminths, along with the immune response in helminthiasis. The book also examines the generation, properties, and mode of action of antibody-independent cytolytic T lymphocytes before concluding with an analysis of the complement system and its reaction pathways as well as its role as an autoantigen.

This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Table of Contents

List of Contributors


Contents of Other Volumes

Chapter 1 Tumor Antigens

I. Introduction

II. Classic Studies of Tumor-Specific Transplantation Antigens

III. Detection of Tumor Antigens

IV. Purification of Tumor Antigens

V. Nature of Tumor Antigens

VI. The Immune Response to Tumor Antigens

VII. The Role of Tumor Antigens in the Escape of Tumors from Immunological Control

VIII. Human Tumor Antigens

IX. Conclusions


Chapter 2 Antigens of Helminths

I. Introduction

II. Immunity to Helminths

III. Pathophysiology of Antigens

IV. Applications: Immunodiagnosis and Immunoprevention

V. Concluding Remarks


Chapter 3 Cytotoxic Lymphocytes

I. Introduction

II. Assay of Lymphocyte-Mediated Cytotoxicity in Vitro

III. Cytolytic T Lymphocytes

IV. Antibody-Dependent Lymphocyte-Mediated Cytotoxicity

V. Natural Cytotoxicity Mediated by Lymphocytes

VI. Concluding Remarks


Chapter 4 Complement

I. Introduction

II. Complement Terminology

III. The Proteins of the Complement Sequence

IV. Components without Clear Homologue

V. The Reaction Mechanisms of Complement

VI. Reaction Mechanisms of the Terminal Portion of the Complement Sequence

VII. Biosynthesis of Complement

VIII. The Biological Properties of the Complement System

IX. Complement as an Autoantigen

X. The Genetics of the Complement System

XI. Complement Components of Cell Membranes

XII. Complement in the Induction of the Antibody Response


Author Index

Subject Index


No. of pages:
© Academic Press 1979
Academic Press
eBook ISBN:

About the Editor

Michael Sela

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