The Antigens - 1st Edition - ISBN: 9780126355024, 9781483269559

The Antigens

1st Edition

Volume II

Editors: Michael Sela
eBook ISBN: 9781483269559
Imprint: Academic Press
Published Date: 28th September 1974
Page Count: 584
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The Antigens, Volume II is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from protein antigens and blood group antigens to low molecular weight antigens and immunoglobulin A. The idiotypy of antibodies is also explored, along with the application of antibodies to the measurement of substances of physiological and pharmacological interest.

Comprised of six chapters, this volume begins with a discussion on the molecular bases of antigenicity and immunogenicity of proteins, followed by a chapter dealing with blood group antigens. The immunologic effects of low molecular weight antigens are then considered, together with their elicitation of allergic reactions and their tolerance and specific inhibition of the immune response. The next chapter focuses on the use of antibodies to measure substances of physiological and pharmacological interest, with emphasis on the general principle of quantitative immunoassay. The book also analyzes the idiotypy of antibodies before concluding with a description of the antibody functions of immunoglobulin A.

This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

Table of Contents

List of Contributors


Contents of Volume I

Chapter 1 Protein Antigens: The Molecular Bases of Antigenicity and Immunogenicity

I. Introduction

I. Molecular Basis of Antigenicity

III. Molecular Basis of Immunogenicity

IV. Summary


Chapter 2 Blood Group Antigens

I. Introduction

II. Glycoprotein Antigen with ABH and Lewis Specificities

III. Glycosphingolipid Antigen with ABH and Lewis Specificities

IV. Immunogenetics and Biosynthesis of ABH and Lewis Antigens

V. Distribution of Blood Group Glycoproteins and Glycolipids

VI. Blood Group Substances in Malignant Cells and Tissues

VII. Chemistry of MN, P, I, J, and Rh Antigens

VIII. Addendum


Chapter 3 Low Molecular Weight Antigens

I. Introduction

II. Immunogenicity

III. Elicitation of Allergic Reactions by Low MW Antigens

IV. Tolerance and Specific Inhibition of the Immune Response by Low MW Antigens

V. Further Special Uses of Low MW Antigens in Immunologic Research

VI. Conclusion and Summary


Chapter 4 The Application of Antibody to the Measurement of Substances of Physiological and Pharmacological Interest

I. The General Principle in Quantitative Immunoassay

II. Detection Principles

III. Requirements of Antibody

IV. The Labeled Antigen

V. The Unlabeled Antigen

VI. Separation Between Free and Bound Antigen

VII. Radioactive Labeling of Antibody

VIII. Validation of Radioimmunoassay

IX. Examples of the Application of General Principles of Immunoassay

X. Concluding Remarks


Chapter 5 Idiotypy of Antibodies

I. Introduction

II. The Technical Means of the Study of Idiotypy

III. Is Each Idiotypic Specificity Peculiar to Antibodies Against a Given Antigen?

IV. The Molecular Localization of the Idiotypic Determinants; The Relationships of Idiotypy with the Atibody Combining Site

V. What Is Known and What May Be Assumed About the Cellular Origin of Idiotypes

VI. Comparison of Idiotopy of the Antibodies Appearing in Different Individuals; The Heterologous Reactions

VII. Comparison of Various Kinds of Antibodies Formed in One Individual Against One Antigenic Material

VIII. Some of the Problems Raised by Idiotypy of Antibodies

IX. Summary


Chapter 6 Immunoglobulin A

I. Introduction

II. Distribution of IgA in the Animal Kingdom

III. Isolation and Quantitative Estimation of IgA

IV. Physicochemical Properties and Structure of IgA

V. Biosynthesis, Metabolism, and Distribution of IgA

VI. Antibody Functions of IgA

VII. IgA in Disease


Author Index

Subject Index


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© Academic Press 1974
Academic Press
eBook ISBN:

About the Editor

Michael Sela

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