The Antigens

List of Contributors

Preface

Contents of Volume I

Chapter 1 Protein Antigens: The Molecular Bases of Antigenicity and Immunogenicity

I. Introduction

I. Molecular Basis of Antigenicity

III. Molecular Basis of Immunogenicity

IV. Summary

References

Chapter 2 Blood Group Antigens

I. Introduction

II. Glycoprotein Antigen with ABH and Lewis Specificities

III. Glycosphingolipid Antigen with ABH and Lewis Specificities

IV. Immunogenetics and Biosynthesis of ABH and Lewis Antigens

V. Distribution of Blood Group Glycoproteins and Glycolipids

VI. Blood Group Substances in Malignant Cells and Tissues

VII. Chemistry of MN, P, I, J, and Rh Antigens

VIII. Addendum

References

Chapter 3 Low Molecular Weight Antigens

I. Introduction

II. Immunogenicity

III. Elicitation of Allergic Reactions by Low MW Antigens

IV. Tolerance and Specific Inhibition of the Immune Response by Low MW Antigens

V. Further Special Uses of Low MW Antigens in Immunologic Research

VI. Conclusion and Summary

References

Chapter 4 The Application of Antibody to the Measurement of Substances of Physiological and Pharmacological Interest

I. The General Principle in Quantitative Immunoassay

II. Detection Principles

III. Requirements of Antibody

IV. The Labeled Antigen

V. The Unlabeled Antigen

VI. Separation Between Free and Bound Antigen

VII. Radioactive Labeling of Antibody

VIII. Validation of Radioimmunoassay

IX. Examples of the Application of General Principles of Immunoassay

X. Concluding Remarks

Refereces

Chapter 5 Idiotypy of Antibodies

I. Introduction

II. The Technical Means of the Study of Idiotypy

III. Is Each Idiotypic Specificity Peculiar to Antibodies Against a Given Antigen?

IV. The Molecular Localization of the Idiotypic Determinants; The Relationships of Idiotypy with the Atibody Combining Site

V. What Is Known and What May Be Assumed About the Cellular Origin of Idiotypes

VI. Comparison of Idiotopy of the Antibodies Appearing in Different Individuals; The Heterologous Reactions

VII. Comparison of Various Kinds of Antibodies Formed in One Individual Against One Antigenic Material

VIII. Some of the Problems Raised by Idiotypy of Antibodies

IX. Summary

References

Chapter 6 Immunoglobulin A

I. Introduction

II. Distribution of IgA in the Animal Kingdom

III. Isolation and Quantitative Estimation of IgA

IV. Physicochemical Properties and Structure of IgA

V. Biosynthesis, Metabolism, and Distribution of IgA

VI. Antibody Functions of IgA

VII. IgA in Disease

References

Author Index

Subject Index