The Alkaloids

The Alkaloids

Chemistry and Physiology

1st Edition - January 1, 1967

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  • Editor: R. H. F. Manske
  • eBook ISBN: 9781483221984

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The Alkaloids: Chemistry and Physiology, Volume IX focuses on alkaloid chemistry. This book discusses the occurence of known aporphines in plants, reductions with sodium in liquid ammonia, alkaloids related to corydaline, and quaternary alkaloids containing an N-methyl group. The phthalideisoquinoline alkaloids, alkaloids containing one diphenyl ether linkage, trisisobutylisoquinoline alkaloids, and alkaloids of Platydesma campanulata are also elaborated. This publication likewise covers the stereochemistry of the ring nitrogen in the tropanes, pharmacologically active synthetic tropanium salts, and alkaloids of apocynaceae. Other topics include the isolation and purification of salamandra alkaloids, biological activity of tylophora alkaloids, and structure of himbosine. This volume is valuable to chemists and researchers interested in alkaloids and their structures.

Table of Contents

  • List of Contributors


    Contents of Previous Volumes

    Chapter 1. The Aporphine Alkaloids

    I. Introduction

    II. New Aporphine Alkaloids

    III. Newly Clarified Structures

    IV. Occurence of Known Aporphines in Plants

    V. Two Aporphines of Unknown Structures from Corydalis gortschakovii

    VI. Syntheses through Phenolic Oxidative Coupling

    VII. Reductions with Sodium in Liquid Ammonia

    VIII. The JV-Demethylation of Quaternary Aporphines

    IX. Properties

    X. Addendum: Additional New Aporphines


    Chapter 2. The Protoberberine Alkaloids

    I. Introduction

    II. Occurrence

    III. Berberine and Related Alkaloids

    IV. Alkaloids Related to Corydaline

    V. Ophiocarpine

    VI. Quaternary Alkaloids Containing an N-Methyl Group

    VII. Synthesis

    VIII. Biosynthesis

    IX. Table of Physical Constants of Protoberberine Alkaloids and Their Derivatives

    X. Addendum


    Chapter 3. Phthalideisoquinoline Alkaloids

    I. Introduction

    II. Shihunine

    III. Constitution

    IV. Syntheses

    V. Discovery, Isolation, and Properties

    VI. Physiology and Pharmacology


    Chapter 4. Bisbenzylisoquinoline and Related Alkaloids

    I. Introduction

    II. Alkaloids Containing One Diphenyl Ether Linkage

    III. Alkaloids Containing Two Diphenyl Ether Linkages

    IV. Alkaloids Containing Three Diphenyl Ether Linkages

    V. Trisisobutylisoquinoline Alkaloids

    VI. Melanthioidine (A Bisphenethylisoquinoline Alkaloid)


    Chapter 5. Lupine Alkaloids

    I. Occurrence

    II. General Properties

    III. Bicyclic Alkaloids

    IV. Tricyclic Alkaloids

    V. Tetracyclic Alkaloids: Sparteine Group

    VI. Tetracyclic Alkaloids: Matrine Group

    VII. Ormosia Alkaloids


    Chapter 6. Quinoline Alkaloids Other Than Those of Cinchona

    I. Introduction

    II. Simple Quinolines and Quinolones

    III. Furoquinoline and Related Alkaloids

    IV. Alkaloids of Lunasia amara and Balfourodendron riedelianum

    V. Alkaloids of Orixa japonica

    VI. Alkaloids of Haplophyllum Species

    VII. Alkaloids of Platydesma campanulata

    VIII. Alkaloids of Macrorungia longistrobus

    IX. Biogenesis


    Chapter 7. The Tropane Alkaloids

    I. Introduction

    II. Structural Elucidation

    III. Absolute Configuration

    IV. Total Syntheses

    V. The Stereochemistry of the Ring Nitrogen in the Tropanes

    VI. Fragmentation of the Tropanes Including Mass Spectrometry

    VII. Biogenesis and Biogenetic Interconversion of the Tropanes

    VIII. Pharmacologically Active Synthetic Tropanium Salts


    Chapter 8. Steroid Alkaloids: Alkaloids of Apocynaceae and Buxaceae

    I. Introduction

    II. Alkaloids of Apocynaceae

    III. Alkaloids of Buxaceae

    IV. Biogenetic Notes


    Chapter 9. The Steroid Alkaloids: The Salamandra Group

    I. Introduction

    II. Isolation and Purification of Salamandra Alkaloids

    III. Structure

    IV. Biosynthesis

    V. Toxicology


    Chapter 10. Nuphar Alkaloids

    I. Occurrence and History

    II. Nupharidine and Deoxynupharidine

    III. Nupharamine

    IV. Dehydrodeoxynupharidine

    V. Nuphamine

    VI. Neothiobinupharidine

    VII. Thiobinupharidine

    VIII. Castoramine


    Chapter 11. The Mesembrine Alkaloids

    I. Introduction

    II. Occurrence and General History

    III. Chemistry of the Alkaloids


    Chapter 12. The Erythrina Alkaloids

    I. Introduction

    II. Synthesis of Degradation and Rearrangement Products

    III. Sterochemistry

    IV. Total Synthesis

    V. Biosynthesis

    VI. Pharmacology

    VII. Addendum


    Chapter 13. Tylophora Alkaloids

    I. Introduction

    II. The Alkaloids of Tylophora asthmatica

    III. The Alkaloids of Tylophora crebriflora

    IV. The Alkaloids of Vincetoxicum officinale

    V. Biogenesis

    VI. Biological Activity of Tylophora Alkaloids


    Chapter 14. The Galbulimima Alkaloids

    I. The Family Himantandraceae

    II. The Alkaloids

    III. The Himbacine Group

    IV. The Structure of Himbosine


    Chapter 15. The Stemona Alkaloids

    I. Introduction

    II. Tuberostemonine

    III. Isotuberostemonine

    IV. Tuberostemonine-A


    Author Index

    Subject Index

Product details

  • No. of pages: 606
  • Language: English
  • Copyright: © Academic Press 1967
  • Published: January 1, 1967
  • Imprint: Academic Press
  • eBook ISBN: 9781483221984

About the Editor

R. H. F. Manske

Affiliations and Expertise

Dominion Rubber Research Laboratory, Guelph, Ontario

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