The Aging Skeleton

The Aging Skeleton

1st Edition - June 21, 1999

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  • Editors: Clifford Rosen, Julie Glowacki, John Bilezikian
  • Hardcover ISBN: 9780120986552
  • eBook ISBN: 9780080542379

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The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.

Key Features

  • Covers all aspects of the aging skeleton in one comprehensive volume
  • Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass
  • Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton
  • Reviews current therapeutic approaches and methods
  • Written by internationally renowned authors and edited by leaders in the field
  • Is the only book available on this subject


Researchers and academic clinicians, students, and postdoctorates in bone/mineral metabolism, endocrinology, orthopedic, and gerontology research; pharmaceutical industry; contract labs.

Table of Contents

  • General Aspects and Models of Aging:
    D. Nelson, Aging Through the Ages.
    S. Sherman, Aging in the Human Species.
    R.P. Heaney, Aging and Calcium Balance.
    D.N. Kalu, Whole Animal Models of Aging.
    L. Lipson, Humans.
    J. Glowacki, Cellular Models.
    Determinants of Peak Bone Mass; Maintenance of Peak Bone Mass:
    E. Seeman, Genetics.
    T. Lloyd, Nutritional.
    M. van der Meulen and D. Carter, Environmental/Mechanical.
    M. Warren, Hormonal Influences on the Establishment of Peak Bone Mass.
    N.H. Bell, Racial.
    D.T. Baran, Determinants of Maintenance of Bone Mass.
    Mechanisms of Age-Related Bone Loss:
    P. Robey, Cellular.
    M. Leboff and J. Glowacki, Sex Steroids.
    S.J. Silverberg and J.P. Bilezikian, Parathyroid Hormone.
    F.M. Gloth, Vitamin D.
    M. Horowitz and L. Raisz, Cytokines.
    S. Mohan, Growth Hormone/IGFs.
    P.H. Stern and P. Lakatos, Other Factors.
    J. Anderson, Nutritional.
    C.T. Rubin and J. Rubin, Constraints of Experimental Paradigms Used to Model the Aging Skeleton.
    Quantifiable Manifestations of Age-Related Bone Loss: M.L. Villa and D. Nelson, Racial/Ethnic Influences on Bone Loss.
    J. Compston, Histomorphometric.
    C. Mautalen, Densitometric.
    C. Gundberg, S. Robins and M. Seibel, Biochemical Dynamics.
    D. Burr and C.H. Turner, Biomechanical Measurements.
    Fractures: A Consequence of the Aging Skeleton:
    M.L. Bouxsein, Applications of Biomechanics to the Aging Human Skeleton.
    R.D. Wasnich, What is a Fragility Fracture?
    P.D. Ross, Epidemiology/Economics of Osteoporotic Fractures.
    M. Nevitt, Sites of Fracture-Spine, Hip, Colles, Other.
    M. August, L. Kaban, The Aging Maxillo-Facial Skeleton.
    D. Gold, Effects on the Quality of Life.
    T. Einhorn and Moffett, General Orthopedics Principles.
    R. Rizzoli, Nutritional and Supportive.
    P. Leong, Analgesic Management.
    T. Thornhill and M. Winemaker, Complications of Prosthetic Replacements.
    M. Sinaki, The Shape and Size of an Osteoporotic Woman.
    D.P. Kiel, Prevention of Falls.
    R. Marcus and B. Beck, Physical Activity.
    R.L. Prince, Calcium.
    R. Lindsay and F. Cosman, Estrogen.
    E.S. Siris and D. Schussheim, SERMS.
    E.S. Orwoll, Androgens.
    S. Papapoulos, Biphosphonates.
    C. Waud and J. Stock, Calcitonin.
    A.B. Hodsman, Parathyroid Hormone.
    C.J. Rosen, Growth Hormone-IGF-1.
    D. Baylink, Fluoride.
    M. Favus, Vitamin D.

Product details

  • No. of pages: 642
  • Language: English
  • Copyright: © Academic Press 1999
  • Published: June 21, 1999
  • Imprint: Academic Press
  • Hardcover ISBN: 9780120986552
  • eBook ISBN: 9780080542379

About the Editors

Clifford Rosen

Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.

Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals.

Affiliations and Expertise

Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Maine, USA

Julie Glowacki

Affiliations and Expertise

Brigham and Women's Hospital and Massachusetts General Hospital, Harvard Medical School and Harvard School of Dental Medicine, Boston, Massachusetts, U.S.A.

John Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and Expertise

Columbia University, New York, New York, U.S.A.

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