The Aging Skeleton is a comprehensive and timely book on all aspects of the skeleton as it ages, including basic mechanisms and pathways as well as pathobiology. Chapters cover general aspects and models of aging, determinants and maintenance of peak bone mass, mechanisms of age-related bone loss, quantifiable manifestations of age-related bone loss, fractures, and therapeutics.

Key Features

@introbul:Key Features @bul:* Covers all aspects of the aging skeleton in one comprehensive volume * Looks at the influence of genetics, nutrition, environment, hormones, and other factors on bone mass * Provides a thorough discussion of fractures, one of the major consequences of the aging skeleton * Reviews current therapeutic approaches and methods * Written by internationally renowned authors and edited by leaders in the field * Is the only book available on this subject


Researchers and academic clinicians, students, and postdoctorates in bone/mineral metabolism, endocrinology, orthopedic, and gerontology research; pharmaceutical industry; contract labs.

Table of Contents

General Aspects and Models of Aging: D. Nelson, Aging Through the Ages. S. Sherman, Aging in the Human Species. R.P. Heaney, Aging and Calcium Balance. D.N. Kalu, Whole Animal Models of Aging. L. Lipson, Humans. J. Glowacki, Cellular Models. Determinants of Peak Bone Mass; Maintenance of Peak Bone Mass: E. Seeman, Genetics. T. Lloyd, Nutritional. M. van der Meulen and D. Carter, Environmental/Mechanical. M. Warren, Hormonal Influences on the Establishment of Peak Bone Mass. N.H. Bell, Racial. D.T. Baran, Determinants of Maintenance of Bone Mass. Mechanisms of Age-Related Bone Loss: P. Robey, Cellular. M. Leboff and J. Glowacki, Sex Steroids. S.J. Silverberg and J.P. Bilezikian, Parathyroid Hormone. F.M. Gloth, Vitamin D. M. Horowitz and L. Raisz, Cytokines. S. Mohan, Growth Hormone/IGFs. P.H. Stern and P. Lakatos, Other Factors. J. Anderson, Nutritional. C.T. Rubin and J. Rubin, Constraints of Experimental Paradigms Used to Model the Aging Skeleton. Quantifiable Manifestations of Age-Related Bone Loss: M.L. Villa and D. Nelson, Racial/Ethnic Influences on Bone Loss. J. Compston, Histomorphometric. C. Mautalen, Densitometric. C. Gundberg, S. Robins and M. Seibel, Biochemical Dynamics. D. Burr and C.H. Turner, Biomechanical Measurements. Fractures: A Consequence of the Aging Skeleton:<


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© 1999
Academic Press
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