Contents. List of Contributors. Preface (D.R. Garrod). Part I Adhesion Molecules and their Ligands. The Molecular Anatomy of Integrins (L.J. Green and M.J. Humphries). The Cadherin Superfamily (J. Stappert and R. Kemler). The Selectins and their Ligands: Adhesion Molecules of the Vasculature (T.F. Tedder, X. Li, and D.A. Steeber). The Immunoglobulin Superfamily (D.L. Simmons). Part II. Organization of Adhesion Complexes. Focal Adhesions and Adherens Junctions: their Role in Tumorigenesis (A. Ben-Ze'ev). Desmosomal Adhesion (D.R. Garrod, C. Tselepis, S.K. Runswick, A.J. North, S.R. Wallis, and M.A.J. Chidgey). The Molecular Basis for the Structure, Function, and Regulation of Tight Junctions (S. Citi and M. Cordenonsi). Part III Signaling by Adhesion Molecules. Activation of Integrin Signaling Pathways by Cell Interactions with Extracellular Matrix (F.M. Edwards and C.H. Streuli). Signaling and Platelet Adhesion (X. Du and M.H. Ginsberg). Signaling by Cell Adhesion Molecules in the Nervous System (J.J. Hemperly). Part IV Adhesive Processes. Vascular Endothelial Cell Adhesion Molecules and the Control of Leukocyte Traffic in Cutaneous Inflammation (D.O. Haskard, J.C. Mason, and J. McHale). The Role of Adhesion in Metastasis: Potential Mechanisms and Modulation of Integrin Activity (J.F. Marshall and I.R. Hart). Integrin Adhesion in Cell Migration (S.P. Palecek, E.A. Cox, A. Huttenlocher, D.A. Lauffenburger, and A.F. Horwitz). Adhesion Receptors: Critical Effectors of Trophoblast Differentiation during Implantation and Placentation (C.H. Damsky, Y. Zhou, O. Genbacev, J. Cross, and S.J. Fisher). Index.