Systemic Lupus Erythematosus

Systemic Lupus Erythematosus

5th Edition - October 29, 2010

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  • Editor: Robert Lahita
  • eBook ISBN: 9780080961712
  • Hardcover ISBN: 9780123749949

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Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

Key Features

  • Highly illustrated and in full color throughout
  • Basic science section expanded to allow the reader to focus on the newest techniques in molecular medicine and its effects on disease expression and treatment
  • Clinical aspects and new drugs will be covered in great detail providing a useful reference to both experienced clinicians and physicians with an interest in lupus in their clinical practice


Basic scientists and clinicians who are interested in SLE including rheumatologists, dermatologists, nephrologists, immunologists and allergists. Residents and fellows in training, primary internists with an interest in the disease and medical libraries

Table of Contents

  • Section I: Basis of Disease Pathogenesis

    A. Genetics

    1 Major histocompatibility complex class II

    Michelle M.A. Fernando and Timothy J. Vyse

    2 Genetic susceptibility and class III complement genes

    John P. Atkinson, Peter M. Schneider and C. Yung Yu

    3 Constitutive genes and lupus

    Betty P. Tsao and Yun Deng

    4 Genetics of lupus in mice

    Dwight H. Kono and Argyrios N. Theofilopoulos

    B. Cellular Pathogenesis

    5 Tolerance and autoimmunity

    Shiv Pillai and Kendra N. Taylor

    6 Dendritic cells in SLE

    Gerlinde Obermoser, Karolina Palucka, Hideki Ueno, Jacques Banchereau, and Virginia Pascual

    7 T cells and systemic lupus erthematosus

    Jose C. Crispin and George C. Tsokos

    8 B-lymphocyte biology in SLE

    Mark J. Mamula

    9 Polymorhonuclear and endothelial cells

    Robert Clancy

    10 Mechanisms and consequences of mitochondrial dysfunction and oxidative stress in T cells of patients with SLE

    Andras Perl

    11 Cell cycle regulation and systemic lupus erythematosus

    Dimitrios Balomenos

    12 The role of reactive nitrogen and oxygen intermediates in systemic lupus erythematosus

    Ahmad K. Mashmoushi, Gary S. Gilkeson and Jim C. Oates

    C. Humoral Pathogenesis

    13 Origins of antinuclear antibodies

    Westley H. Reeves, Yuan Xu, Haoyang Zhuang, Yi Li and Lijun Yang

    14 Anti-DNA antibodies: Structure, regulation and pathogenicity

    Cynthia Aranow, Dun Zhou and Betty Diamond

    15 Extractable nuclear antigens and SLE: specificity and role in disease pathogenesis

    Mary Keogan, Grainne Kearns and Caroline A. Jefferies

    16 Antihistone and antispliceosomal antibodies

    Minoru Satoh, Marvin J. Fritzler, and Edward K.L. Chan

    17 Toll-like receptors in SLE

    Terry K. Means

    18 Interferon-alpha in systemic lupus erythematosus

    Mary K. Crow

    19 Immune complexes in systemic lupus erythematosus

    Mark H. Wener

    20 Complement and tissue injury in SLE

    Chau-Ching Liu and Joseph Ahearn

    21 Humoral pathogenesis: Fc receptors in autoimmunity and end-organ damage

    T. Ernandez and T.N. Mayadas

    D. Environmental Aspects of Pathogenesis

    22 Drug-induced lupus mechanisms

    Raymond L. Yung and Bruce C. Richardson

    23 Gender and age in lupus

    Robert G. Lahita

    24 Roles for infections in systemic lupus erythematosus pathogenesis

    Evan S. Vista, A. Darise Farris and Judith A. James

    25 Systemic lupus erythematosus in domestic animals

    Michael J. Day

    E. Mechanisms of Tissue Injury

    26 Pathogenesis of lupus nephritis

    Yong Du and Chandra Mohan

    27 Tissue injury and the skin

    Annegret Kuhn, Markus Bohm and Thomas A. Luger

    28 Neuropsychiatric systemic lupus erythematosus: Mechanisms of injury

    Meggan Mackay, Aziz M. Ulug and Bruce T. Volpe

    29 Atherosclerosis and tissue injury in systemic lupus erythematosus

    Ingrid Avalos and C. Michael Stein

    Section II: Clinical Aspects of Disease

    A. Clinical Presentation

    30 The clinical presentation of systemic lupus erythematosus

    Robert G. Lahita

    31 Neonatal lupus

    Jill P. Buyon and Deborah M. Friedman

    32 SLE in children
    Rina Mina and Hermine I. Brunner

    33 Drug-induced disease

    Anne-Barbara Mongey and Evelyn V. Hess

    34 Laboratory evaluation of patients with systemic lupus erythematosus

    Peter H. Schur

    35 Pregnancy and reproductive concerns in systemic lupus erythematosus

    Carl Laskin, Karen Spitzer and Christine A. Clark

    36 Epidemiology of systemic lupus erythematosus

    Catia Duarte, Maura Couto, Luis Ines and Matthew H. Liang

    37 Monitoring disease activity

    Kenneth C. Kalunian and Joan T. Merrill

    38 Incomplete lupus erythematosus

    Johannes C. Nossent and Tom J.G. Swaak

    39 Design of clinical trials for SLE

    Joan T. Merrill, Ken Kalunian and Jill P. Buyon

    B. Organ Systems

    40 The nervous system and lupus

    John G. Hanly

    41 Skin

    Victoria P. Werth, Cristian Vera-Kellet and Jan P. Dutz

    42 Kidney

    Brad H. Rovin and Isaac E. Stillman

    43 Heart

    Kathleen Macsimowicz-McKinnon and Susan Manzi

    44 Vasculitis

    Barri Fessler and Gary S. Hoffman

    45 Lung

    Aryeh Fischer and Roland M. du Bois

    46 Gastrointestinal: Liver

    Ian R. Mackay

    47 Gastrointestinal: Nonhepatic

    Lloyd Mayer

    48 Cellular hematology

    Seetha U. Monrad and Mariana J. Kaplan

    49 Musculoskeletal system: Articular disease, bone metabolism

    Diane Horowitz, Galina Marder and Richard Furie

    Section III: Anti-Phospholipid Syndrome

    A. Pathogenesis

    50 Antiphospholipid antibody: Pathogenesis

    Takao Koike, Tatsuya Atsumi and Olga Amengual

    51 Endothelial cell damage and atherosclerosis

    Joan T. Merrill

    B. Clinical

    52 Laboratory testing for antiphospholipid syndrome

    Steven Krilis and Yiannia Ioannou

    53 Clinical presentation of antiphospholipid syndrome

    Munther A. Khamashta

    54 Pregnancy and antiphospholipid syndrome

    Kristina Milan and D. Ware Branch

    55 Treatment of antiphospholipid syndrome

    Gerard Espinosa and Richard Cervera

    Section IV: Treatment

    56 Steroids and nonsteroidal anti-inflammatory drugs

    Olga Dvorkina and Ellen M. Ginzler

    57 Antimalarials

    Nathalie Costedoat-Chalumeau, Gaelle Leroux, Jean-Charles Piette and Zahir Amoura

    58 Cytotoxic agents

    Eva D. Papadimitraki, George Bertsias, George Chamilos and Dimitrios T. Boumpas

    59 Biological agents

    Vasileios C. Kyttaris

Product details

  • No. of pages: 1154
  • Language: English
  • Copyright: © Academic Press 2010
  • Published: October 29, 2010
  • Imprint: Academic Press
  • eBook ISBN: 9780080961712
  • Hardcover ISBN: 9780123749949

About the Editor

Robert Lahita

Dr. Robert Lahita is Clinical Professor of Medicine at Rutgers University, and the Director of the Institute for Autoimmune and Rheumatic Diseases. He is a fellow of the ACP and the Royal College, and a master of the ACR. Dr. Lahita is the author of more than 16 books and 150 scientific publications in the field of autoimmunity. He is the editor of the standard textbook Systemic Lupus Erythematosus and the Senior Editor of the Textbook of Autoimmunity, and the author of Lupus: Q and A for patients and Autoimmunity in Women.

Affiliations and Expertise

Professor of Medicine, Adjunct Professor of Biochemistry and Molecular Biology UMDNJ, New Jersey Medical School Vice President and Chairman of Medicine Newark Beth Israel Medical Center Newark, NJ, USA

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