Synthetic Analgesics

Part IIA. Morphinans I. Chemistry of Morphinans 1. Introduction 2. Synthesis of Analgesics with Morphine-like Activity 3. Synthesis of N-Methyl-Morphinan by Grewe 4. Synthesis of 3-Hydroxy-N-Methyl-Morphinan and Analogous Compounds 5. Optically Active 3-Hydroxymorphinans 6. Isomorphinans 7. Structure of the By-Products of the Morphinan Synthesis 8. Compilation of the Morphinan Derivatives 9. Synthesis of Morphinan-like Compounds II. Pharmacology of Morphinans 1. Toxicity and Analgesic Action of Morphinans 2. Morphinans with Anti-Morphine Activity 3. Anti-Tussive Action of Morphinans 4. Anti-Rheumatic Action of Morphinans 5. Metabolism of Morphinans ReferencesPart IIB. 6,7-Benzomorphans Introduction III. Chemistry of 6,7-Benzomorphans 1. 5-Alkyl-2(N-Methyl-6,7-Benzomorphans 2. α- and ß-5,9-Dialkyl-2(N)-Methyl-6,7-Benzomorphans 3. α- and ß-9-Hydroxy-2(N)-Methyl-6,7-Benzomorphans 4. N-Substituted (Other than Methyl)-6,7-Benzomorphans 5. Optically Active 5,9-Dialkyl-6,7-Benzomorphans - Absolute Configuration 6. Miscellaneous 6,7-Benzomorphans IV. Pharmacology of 6,7-Benzomorphans 1. Analgesic and Toxic Effects in Animals 2. Studies of Physical Dependence Capacity and Chronic Administration in Monkeys 3. Effects in Man, including Studies of Tolerance and Physical Dependence V. Opiate Antagonists in the Benzomorphan Series VI. SummaryReferencesAuthor IndexSubject IndexOther Titles in the Series