Synthetic Analgesics

Synthetic Analgesics

Morphinans: Benzomorphans

1st Edition - January 1, 1966

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  • Authors: J. Hellerbach, O. Schnider, H. Besendorf
  • eBook ISBN: 9781483156286

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Description

Synthetic Analgesics provides a comprehensive discussion of morphinans and 6,7-benzomorphans. Morphinans belong to a class of compounds possessing the main structural skeleton of morphine. Chemists have attempted to modify the morphine molecule in order to obtain analgesics without side-effects and addictive properties. The book is organized into two parts. Part A discusses the chemistry and pharmacology of morphinans, covering the syntheses of analgesics with morphine-like activity, N-methyl-morphinan, 3-hydroxy-N-methyl-morphinan and analogous compounds, toxicity and analgesic action of morphinan, and morphinans with anti-morphine activity. Part B deals with the chemistry and pharmacology of 6,7-benzomorphans; and opiate antagonists in the benzomorphan series.

Table of Contents


  • Part IIA. Morphinans

    I. Chemistry of Morphinans

    1. Introduction

    2. Synthesis of Analgesics with Morphine-like Activity

    3. Synthesis of N-Methyl-Morphinan by Grewe

    4. Synthesis of 3-Hydroxy-N-Methyl-Morphinan and Analogous Compounds

    5. Optically Active 3-Hydroxymorphinans

    6. Isomorphinans

    7. Structure of the By-Products of the Morphinan Synthesis

    8. Compilation of the Morphinan Derivatives

    9. Synthesis of Morphinan-like Compounds

    II. Pharmacology of Morphinans

    1. Toxicity and Analgesic Action of Morphinans

    2. Morphinans with Anti-Morphine Activity

    3. Anti-Tussive Action of Morphinans

    4. Anti-Rheumatic Action of Morphinans

    5. Metabolism of Morphinans

    References

    Part IIB. 6,7-Benzomorphans

    Introduction

    III. Chemistry of 6,7-Benzomorphans

    1. 5-Alkyl-2(N-Methyl-6,7-Benzomorphans

    2. α- and ß-5,9-Dialkyl-2(N)-Methyl-6,7-Benzomorphans

    3. α- and ß-9-Hydroxy-2(N)-Methyl-6,7-Benzomorphans

    4. N-Substituted (Other than Methyl)-6,7-Benzomorphans

    5. Optically Active 5,9-Dialkyl-6,7-Benzomorphans - Absolute Configuration

    6. Miscellaneous 6,7-Benzomorphans

    IV. Pharmacology of 6,7-Benzomorphans

    1. Analgesic and Toxic Effects in Animals

    2. Studies of Physical Dependence Capacity and Chronic Administration in Monkeys

    3. Effects in Man, including Studies of Tolerance and Physical Dependence

    V. Opiate Antagonists in the Benzomorphan Series

    VI. Summary

    References

    Author Index

    Subject Index

    Other Titles in the Series


Product details

  • No. of pages: 200
  • Language: English
  • Copyright: © Pergamon 1966
  • Published: January 1, 1966
  • Imprint: Pergamon
  • eBook ISBN: 9781483156286

About the Authors

J. Hellerbach

O. Schnider

H. Besendorf

About the Editors

D. H. R. Barton

W. Von Doering

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