Studies in Natural Products Chemistry, Volume 41

1st Edition

Series Volume Editors: Atta-ur- Rahman
Hardcover ISBN: 9780444632944
eBook ISBN: 9780444632951
Imprint: Elsevier
Published Date: 20th January 2014
Page Count: 536
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Table of Contents

Contributors
Preface
Chapter 1: Recent Insights into the Emerging Role of Triterpenoids in Cancer Therapy: Part II
Abstract

Introduction

Antitumor Activity of Triterpenoids

Concluding Remarks

Chapter 2: Highlights of Pentacyclic Triterpenoids in the Cancer Settings
Abstract

Introduction to Triterpenoids

Cancer and Triterpenoids

Anticancer Activity of Natural Pentacyclic Triterpenoids

Semisynthetic Pentacyclic Triterpenoids and Cancer

Conclusions

Chapter 3: Immunomodulatory and Anticancer Activity of Sea Cucumber Triterpene Glycosides
Abstract

Introduction

Anticancer Activity

Immunomodulatory Activity

Conclusion

Acknowledgments

Chapter 4: Bioactive Annonaceous Acetogenins
Abstract

Introduction

Sources of ACGs

Quantitative and Qualitative Analysis of ACGs

Potential Health Benefits of ACGs

Toxicity

New Chemical Entities

Acknowledgment

Chapter 5: Bioactive Naphthoquinones from Higher Plants
Abstract

Introduction

Distribution of Naphthoquinones Within the Plant Kingdom

The Main Naphthoquinone-Containing Orders

Plant Cell, Tissue, and “Hairy” Root Cultures

Biological Activity of Naphthoquinones

Cytotoxicity and Anticancer Activity

Antibacterial Activity

Anti-Inflammatory Activity

Antiparasitic Activity

Antifungal

Discussion and Concluding Remarks

Chapter 6: Antiobesity Effects of Natural Products from an Epigenetic Perspective
Abstract

Introduction

Natural Products with Antiobesity Effects

DNA Methylation

Histone Modifications

Obesigenic Gene

Natural Products Affecting Epigenetic Mechanisms

Flavonoid-Related Compounds

Resveratrol

Curcumin

Organosulfur Compounds

Methyl Donor Me


Description

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.

The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable resource for natural products and medicinal chemistry

Details

No. of pages:
536
Language:
English
Copyright:
© Elsevier 2014
Published:
Imprint:
Elsevier
eBook ISBN:
9780444632951
Hardcover ISBN:
9780444632944

About the Series Volume Editors

Atta-ur- Rahman Series Volume Editor

Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan. Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions. He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011. He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal M

Affiliations and Expertise

University of Karachi, Pakistan