Studies in Natural Products Chemistry - 1st Edition - ISBN: 9780444632944, 9780444632951

Studies in Natural Products Chemistry, Volume 41

1st Edition

Series Volume Editors: Atta-ur- Rahman
eBook ISBN: 9780444632951
Hardcover ISBN: 9780444632944
Imprint: Elsevier
Published Date: 20th January 2014
Page Count: 536
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Table of Contents

Contributors
Preface
Chapter 1: Recent Insights into the Emerging Role of Triterpenoids in Cancer Therapy: Part II
Abstract

Introduction

Antitumor Activity of Triterpenoids

Concluding Remarks

Chapter 2: Highlights of Pentacyclic Triterpenoids in the Cancer Settings
Abstract

Introduction to Triterpenoids

Cancer and Triterpenoids

Anticancer Activity of Natural Pentacyclic Triterpenoids

Semisynthetic Pentacyclic Triterpenoids and Cancer

Conclusions

Chapter 3: Immunomodulatory and Anticancer Activity of Sea Cucumber Triterpene Glycosides
Abstract

Introduction

Anticancer Activity

Immunomodulatory Activity

Conclusion

Acknowledgments

Chapter 4: Bioactive Annonaceous Acetogenins
Abstract

Introduction

Sources of ACGs

Quantitative and Qualitative Analysis of ACGs

Potential Health Benefits of ACGs

Toxicity

New Chemical Entities

Acknowledgment

Chapter 5: Bioactive Naphthoquinones from Higher Plants
Abstract

Introduction

Distribution of Naphthoquinones Within the Plant Kingdom

The Main Naphthoquinone-Containing Orders

Plant Cell, Tissue, and “Hairy” Root Cultures

Biological Activity of Naphthoquinones

Cytotoxicity and Anticancer Activity

Antibacterial Activity

Anti-Inflammatory Activity

Antiparasitic Activity

Antifungal

Discussion and Concluding Remarks

Chapter 6: Antiobesity Effects of Natural Products from an Epigenetic Perspective
Abstract

Introduction

Natural Products with Antiobesity Effects

DNA Methylation

Histone Modifications

Obesigenic Gene

Natural Products Affecting Epigenetic Mechanisms

Flavonoid-Related Compounds

Resveratrol

Curcumin

Organosulfur Compounds

Methyl Donor Metabolism

Conclusion

Chapter 7: Natural Polyphenols as Potent Inhibitors of DNA Methyltransferases
Abstract

Introduction

Epigenetics, DNA Methylation, and Cancer

Chemistry of DNA Methylation and Demethylation

Polyphenol Inhibitors of DNMT

Other Natural Product DNMTi

Conclusion

Acknowledgments

Chapter 8: The Chemistry and Bioactivity of Eucommia ulmoides Oliver Leaves
Abstract

Introduction

Chemistry of Compounds from E. ulmoides Oliver Leaves

Bioactivities of Compounds from E. ulmoides Leaves

Acknowledgments

Chapter 9: Aloe Vera Gel in Food, Health Products, and Cosmetics Industry
Abstract

Introduction

Aloe Vera Gel Chemistry

Medicinal Uses of Aloe Vera Juice

Aloe Vera Gel Applications

Aloe Vera as Food Supplement

Aloe Vera in Cosmetics

Processing of Aloe Vera Gel

Production Methods

Aloe Concentrate

Aloe Powder

Quality Control and Safety Aspects of Aloe Products

Conclusion

Chapter 10: Synthesis of Marine-Derived Carbasugar Pericosines
Abstract

Introduction

First Synthesis of (+)-Pericosine B by Donohoe

Synthesis of Epimer of Pericosine B: Synthesis of (+)-Pericosine C

Syntheses of Initially Assigned Pericosine A and Its Diastereomer

First Total Synthesis of Revised Pericosine A: Determination of Absolute Configuration

Syntheses of Pericosines Strating from D-Ribose via Ring-Closing Metathesis

Second-Generation Syntheses of Pericosines A and C by the Usami Group

Syntheses of (+)-Pericosines A–C by Stevenson

Synthesis of (−)-Pericosine B by the Usami Group

Chiral HPLC Analyses of Some Natural Pericosines

Syntheses of Pericosines via Ring-Closing Metathesis Starting from D-Ribose

Conclusion

Acknowledgments

Chapter 11: Bioactive Components from Leaf Vegetable Products
Abstract

Introduction

Ascorbic Acid

Polyphenols

Carotenoids

Tocopherols and Tocotrienols

Phytosterols

Melatonin

Sulfur Compounds

New Perspectives and Potential Applications of Leaf Vegetable Products

Concluding Remarks

Acknowledgments

Chapter 12: Milk Fat Globule Membrane Material: Isolation Techniques, Health-Beneficial Properties, and Potential Applications
Abstract

Introduction

Composition of MFGM

Structure of MFGM

Distribution of MFGM During Dairy Processing

Isolation and Purification of MFGM Material

Nutraceutical Properties of MFGM Components

Applications of MFGM Material

General Conclusions and Perspectives

Chapter 13: Determination of the Absolute Configuration of Natural Product Molecules Using Vibrational Circular Dichroism
Abstract

Introduction

Theoretical Background

AC Determination Using VCD

Calculations of Theoretical Spectra

Examples of Application

Concluding Remarks

Acknowledgments

Chapter 14: Bioactive Metabolites from Rare Actinomycetes
Abstract

Introduction

Bioactive Compounds from Rare Actinomycetes

Techniques for Isolation of Rare Actinomycetes

Antibiotics from Rare Actinomycetes: Structural and Chemical Diversity

Novel Classes of Antibiotics

Conclusion

Index


Description

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.

The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable resource for natural products and medicinal chemistry

Details

No. of pages:
536
Language:
English
Copyright:
© Elsevier 2014
Published:
Imprint:
Elsevier
eBook ISBN:
9780444632951
Hardcover ISBN:
9780444632944

About the Series Volume Editors

Atta-ur- Rahman Series Volume Editor

Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan.

Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions.

He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011.

He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal Minister of Education (2002) and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. The Austrian government also honoured him with its highest civil award ("Das Große Goldene Ehrenzeichen am Bande", 2007) in recognition of his eminent contributions.

Prof. Atta-ur-Rahman was the Coordinator General of COMSTECH, an OIC Ministerial Committee comprising the 57 Ministers of Science & Technology from 57 OIC member countries during 1996-2012. He is also the Patron of International Centre of Chemical and Biological Sciences (which comprises a number of institutes, including the Hussain Ebrahim Jamal Research Institute of Chemistry and the Dr. Panjwani Center of Molecular Medicine and Drug Development) at Karachi University.

He established a research center on Genomics in Karachi University. In recognition of the eminent contributions of Prof. Atta-ur-Rahman, a number of institutions have been named after him within and outside Pakistan. These include a natural product chemistry institute (Atta-ur-Rahman Research Institute of Natural Product Discovery, RiND) at the University of Technology Mara in Malaysia, Atta-ur-Rahman School of Applied Biosciences at National University of Science & Technology in Islamabad, and Dr. Atta-ur-Rahman Building at the International Centre for Chemical and Biological Sciences, University of Karachi. The Academy of Sciences in the Developing World (TWAS) based in Trieste, Italy has introduced a Dr. Atta-ur-Rahman Prize in Chemistry to a scientist from the developing world each year. The Prize carries a cash award of $ 5,000 and a Certificate.

Affiliations and Expertise

University of Karachi, Pakistan