Description

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.

The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable resource for natural products and medicinal chemistry

Table of Contents

Contributors
Preface
Chapter 1: Recent Insights into the Emerging Role of Triterpenoids in Cancer Therapy: Part II
Abstract

Introduction

Antitumor Activity of Triterpenoids

Concluding Remarks

Chapter 2: Highlights of Pentacyclic Triterpenoids in the Cancer Settings
Abstract

Introduction to Triterpenoids

Cancer and Triterpenoids

Anticancer Activity of Natural Pentacyclic Triterpenoids

Semisynthetic Pentacyclic Triterpenoids and Cancer

Conclusions

Chapter 3: Immunomodulatory and Anticancer Activity of Sea Cucumber Triterpene Glycosides
Abstract

Introduction

Anticancer Activity

Immunomodulatory Activity

Conclusion

Acknowledgments

Chapter 4: Bioactive Annonaceous Acetogenins
Abstract

Introduction

Sources of ACGs

Quantitative and Qualitative Analysis of ACGs

Potential Health Benefits of ACGs

Toxicity

New Chemical Entities

Acknowledgment

Chapter 5: Bioactive Naphthoquinones from Higher Plants
Abstract

Introduction

Distribution of Naphthoquinones Within the Plant Kingdom

The Main Naphthoquinone-Containing Orders

Plant Cell, Tissue, and “Hairy” Root Cultures

Biological Activity of Naphthoquinones

Cytotoxicity and Anticancer Activity

Antibacterial Activity

Anti-Inflammatory Activity

Antiparasitic Activity

Antifungal

Discussion and Concluding Remarks

Chapter 6: Antiobesity Effects of Natural Products from an Epigenetic Perspective
Abstract

Introduction

Natural Products with Antiobesity Effects

DNA Methylation

Histone Modifications

Obesigenic Gene

Natural Products Affecting Epigenetic Mechanisms

Flavonoid-Related Compounds

Resveratrol

Curcumin

Organosulfur Compounds

Methyl Donor Me

Details

No. of pages:
536
Language:
English
Copyright:
© 2014
Published:
Imprint:
Elsevier
Print ISBN:
9780444632944
Electronic ISBN:
9780444632951