Description

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.

The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  •  Presents exciting sources of new pharmacophores

Readership

Natural product chemists, medicinal chemists, pharmacologists as well as researchers particularly those in academia and in the pharmaceutical industry

Table of Contents

Contributors
Preface
Chapter 1: Glycosphingolipid Ligands for Invariant Natural Killer T cells as Immunostimulants
Abstract

Introduction

Synthesis of KRN7000

X-Ray Crystallographic Analysis

Stereostructure of the Sphingosine Part of KRN7000

SAR Studies on KRN7000

Th1-Type Analogs of KRN7000

Th2-Type Analogs of KRN7000

Summary of SAR Study

Evaluation of the Binding Affinity by SPR Spectroscopy

Molecular Dynamics Simulation Study

Research Intended to Discover the Natural Microbial and Endogenous Ligands of NKT Cells

Concluding Remarks

Acknowledgments

Chapter 2: Synthesis of Imidazole Alkaloids Originated in Marine Sponges
Abstract

Introduction

Syntheses of Naamidines A–I

Syntheses of Preclathridine A and Clathridine A

Syntheses of Naamines

Syntheses of Isonaamines and Isonaamidines

Synthesis of Pyronaamidine

Discovered, but not yet Synthesized Imidazole Alkaloids

Chapter 3: Cerebrosides from Marine Organisms
Abstract

Introduction

Isolation and Purification

Structural Elucidation

Chemical Structures

Conclusions

Acknowledgments

Chapter 4: Isolation and Analysis of Lignin–Carbohydrate Complexes Preparations with Traditional and Advanced Methods: A Review
Abstract

Introduction

Isolation of LCC Preparations from Wood and Pulps

LCC Analysis

Quantification of LCC Linkages

General Discussion

Implementation of Enzymes in LCC Studies

Conclusions

Chapter 5: Isolation, Characterization, and Biological Activities of Polysaccharides from Medicinal Plants and Mushrooms
Abstract

Introduction

Molecular Basis of Cancer Formation and Development

Isolation and Purification of Polysaccharides

Polysaccharide Structure–Function Relationship and

Details

No. of pages:
500
Language:
English
Copyright:
© 2014
Published:
Imprint:
Elsevier
eBook ISBN:
9780444632821
Print ISBN:
9780444632814

About the series-volume-editor

Atta-ur- Rahman

Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan. Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions. He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011. He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal M

Affiliations and Expertise

University of Karachi, Pakistan