Description

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.

The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  •  Presents exciting sources of new pharmacophores

Readership

Natural product chemists, medicinal chemists, pharmacologists as well as researchers particularly those in academia and in the pharmaceutical industry

Table of Contents

Contributors
Preface
Chapter 1: Glycosphingolipid Ligands for Invariant Natural Killer T cells as Immunostimulants
Abstract

Introduction

Synthesis of KRN7000

X-Ray Crystallographic Analysis

Stereostructure of the Sphingosine Part of KRN7000

SAR Studies on KRN7000

Th1-Type Analogs of KRN7000

Th2-Type Analogs of KRN7000

Summary of SAR Study

Evaluation of the Binding Affinity by SPR Spectroscopy

Molecular Dynamics Simulation Study

Research Intended to Discover the Natural Microbial and Endogenous Ligands of NKT Cells

Concluding Remarks

Acknowledgments

Chapter 2: Synthesis of Imidazole Alkaloids Originated in Marine Sponges
Abstract

Introduction

Syntheses of Naamidines A–I

Syntheses of Preclathridine A and Clathridine A

Syntheses of Naamines

Syntheses of Isonaamines and Isonaamidines

Synthesis of Pyronaamidine

Discovered, but not yet Synthesized Imidazole Alkaloids

Chapter 3: Cerebrosides from Marine Organisms
Abstract

Introduction

Isolation and Purification

Structural Elucidation

Chemical Structures

Conclusions

Acknowledgments

Chapter 4: Isolation and Analysis of Lignin–Carbohydrate Complexes Preparations with Traditional and Advanced Methods: A Review
Abstract

Introduction

Isolation of LCC Preparations from Wood and Pulps

LCC Analysis

Quantification of LCC Linkages

General Discussion

Implementation of Enzymes in LCC Studies

Conclusions

Chapter 5: Isolation, Characterization, and Biological Activities of Polysaccharides from Medicinal Plants and Mushrooms
Abstract

Introduction

Molecular Basis of Cancer Formation and Development

Isolation and Purification of Polysaccharides

Polysaccharide Structure–Function Relationship and

Details

No. of pages:
500
Language:
English
Copyright:
© 2014
Published:
Imprint:
Elsevier
Electronic ISBN:
9780444632821
Print ISBN:
9780444632814