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Studies in Natural Products Chemistry - 1st Edition - ISBN: 9780444639318, 9780444639370

Studies in Natural Products Chemistry, Volume 52

1st Edition

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Editor: Atta-ur Rahman
Hardcover ISBN: 9780444639318
eBook ISBN: 9780444639370
Imprint: Elsevier
Published Date: 20th February 2017
Page Count: 514
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Table of Contents

Chapter 1. Natural Environments for Nanoparticles Synthesis of Metal, Metal Oxides, Core–Shell and Bimetallic Systems


Key Concepts of Biological Nanosynthesis, State of the Art

Biosynthesis of NPs by Bacteria

Biosynthesis of NPs by Fungi

Biosynthesis of NPs in Plant Extracts

Core@Shell and Mixed NPs

Mechanistic Concepts


Terms, Abbreviations, and Acronyms

Chapter 2. 2-Aminoimidazoles: Synthesis by Ring Transformation Reactions


Synthesis of Aminoimidazoles From Aminooxazoles

Synthesis of Fused Aminoimidazoles From Aminooxazoles

Synthesis of Aminoimidazoles From Other Azoles

Synthesis of Aminoimidazoles From Imidazopyrimidines

Synthesis of Aminoimidazoles From Other Heterocycles


Chapter 3. Strategies for Total Synthesis of Furanocembranolides and Related Natural Products From Marine Organisms


Synthesis of Acerosolide

Synthesis of Bipinnatin J

Synthesis of Rubifolide

Synthesis of Deoxypukalide

Further Synthetic Studies Toward Furanocembranolides

Furanocembranolid Derivatives and Related Compounds

Concluding Remarks

Chapter 4. Phyllobilins: A New Group of Bioactive Compounds


Catabolism of Chlorophyll Pigments

The PaO/Phyllobilin Pathway

Regulation of the PaO/Phyllobilin Route

Structural Characteristics of the FCCs and DFCCs

Transport Into Vacuole and Isomerization to NCCs and DNCCs

Further Linear Chlorophyll Catabolites

Methods of Analysis of Phyllobilins

Extraction Procedures From Vegetal Tissues

Analytical and Semipreparative HPLC Methodologies

Structural Elucidation and Identification: Nuclear Magnetic Resonance

Structural Elucidation and Identification: Mass Spectrometry

Biological Properties of Phyllobilins

Chlorophyll Metabolism in Animals

Concluding Remarks


Chapter 5. Artemisinin the Nobel Molecule: From Plant to Patient


From the Plant: ART Biosynthesis

To the Patient



Chapter 6. Bioactive Polyphenols for Diabetes and Inflammation in Psoriasis Disease


Polyphenols From Forest Resources

Physiopathology of Diabetes Mellitus

Impact of Forest Biomass Polyphenols on Type 2 Diabetes Mellitus

Current Concepts of Psoriasis Pathogenesis

Natural Treatments for Psoriasis: Role of Forest Biomass Polyphenols

Research Perspective

Concluding Remarks


Chapter 7. Nonhalogenated Heterotricyclic Sesquiterpenes From Marine Origin I: Fused Systems


Fused Heterocyclic Sesquiterpenes



Chapter 8. Phytochemicals With Antileishmanial Activity: Prospective Drug Targets


Inhibition of Parasite Proteins as Prospective Drug Targets

Inhibition of Metabolic Pathway of Parasite as Prospective Drug Targets



Chapter 9. Parthenolide and Parthenolide-Like Sesquiterpene Lactones as Multiple Targets Drugs: Current Knowledge and New Developments


New Sources of Parthenolide

Pharmacology of Parthenolide

Synergistic Effects to Improving the Chemosensitivity to Parthenolide

Parthenolide Delivery

Pharmacology of Parthenolide-Like Sesquiterpene Lactones

Concluding Remarks


Chapter 10. Alkaloids From Apocynaceae: Origin, Pharmacotherapeutic Properties, and Structure-Activity Studies


Anticancer Activities of Apocynaceaeous Alkaloids

Neuroprotective and Psychoactive Activities of Apocynaceaeous Alkaloids

Biocidal Activities of Apocynaceaeous Alkaloids

Other Pharmacological Properties of Apocynaceaeous Alkaloids

Structure Activity Relationships

Derivatives and Synthetic Analogues

Concluding Remarks



Studies in Natural Products Chemistry covers the synthesis, testing, and recording of the medicinal properties of natural products, providing cutting-edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis, and pharmacology of a diverse array of bioactive natural products.

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry.

Key Features

  • Focuses on the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • Presents sources of new pharmacophores


Natural product chemists, medicinal chemists, pharmacologists as well as academic and industry researchers


No. of pages:
© Elsevier 2017
20th February 2017
Hardcover ISBN:
eBook ISBN:

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About the Editor

Atta-ur Rahman

Atta-ur Rahman

Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 930 publications in several fields of organic chemistry.

Affiliations and Expertise

International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan