Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

1st Edition - June 25, 2013

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  • Editor: Atta-ur Rahman
  • eBook ISBN: 9780444626325

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Description

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable resource for natural products and medicinal chemistry

Readership

Natural product chemists, medicinal chemists, pharmacologists as well as researchers particularly those in academia and in the pharmaceutical industry

Table of Contents

  • Contributors

    Preface

    Chapter 1. Recent Insights into the Emerging Role of Triterpenoids in Cancer Therapy: Part I

    Abbreviations

    Introduction

    Mechanisms of the Antitumor Effect of Triterpenoids

    Concluding Remarks

    References

    Chapter 2. Recent Advances in Medicinal Applications of Brassinosteroids, a Group of Plant Hormones

    Abbreviations

    Introduction

    Source of BRs

    Toxicity of BRs

    Similarity of BRs to Animal Steroid Hormones

    Anabolic Effect of BRs

    Anticancer and Antiproliferative Properties of BRs

    Antiangiogenic Properties of BRs

    Antiviral Properties of BRs

    Neuroprotective Action of BRs

    Concluding Remarks

    References

    Chapter 3. Synthesis of Bioactive Natural Products by Propargylic Carboxylic Ester Rearrangements

    Introduction

    Synthesis of Bioactive Natural Products by Rearrangement of Propargylic Esters via 1,2-Acyl Migration

    Synthesis of Bioactive Natural Products by Rearrangement of Propargylic Esters via 1,3-Acyl Migration: [3,3]-Sigmatropic Rearrangement of Propargylic Esters

    Conclusions

    Acknowledgments

    References

    Chapter 4. Catalytic Asymmetric Strategies for the Synthesis of 3,3-Disubstituted Oxindoles

    Introduction

    Strategies Based on Cyclization Reactions for the Construction of the Lactam Ring

    Asymmetric Rearrangements of O-Carbonylated Oxindoles and Related Processes

    3-Substituted Oxindoles as Nucleophiles: Alkylation, Conjugate Addition, Aldol, and Mannich Reactions

    Addition of Carbon Nucleophiles to Isatins or to Isatin Imines

    Asymmetric Michael Additions to Isatin-Derived Electron-Deficient Alkenes and Related Processes

    Amination, Hydroxylation, and Halogenation Reactions of 3-Substituted Oxindoles

    Nucleophilic Substitution Reactions of Functionalized 3-Substituted Oxindoles

    Concluding Remarks

    Acknowledgments

    References

    Chapter 5. Abyssomicins: Isolation, Properties, and Synthesis

    Abbreviations

    Introduction

    Secondary Metabolites from Actinomycetes

    Isolation, Structure, Biosynthesis, and Biological Properties of Abyssomicins

    Synthesis of Abyssomicins

    Synthetic Studies

    Conclusion

    References

    Chapter 6. Progress in the Syntheses of Dibenzocyclooctadiene Lignans

    Abbreviations

    Introduction

    Structural Characteristics and Classifications of Dibenzocyclooctadiene Lignans

    Dibenzocyclooctadiene Lignan Syntheses

    Conclusion

    Acknowledgment

    References

    Chapter 7. Lessons from the Sea: Distribution, SAR, and Molecular Mechanisms of Anti-inflammatory Drugs from Marine Organisms

    Abbreviations

    Introduction

    Physiopathology of Inflammation

    Molecular Targets in Inflammation

    Anti-inflammatory Marine Drugs

    Concluding Remarks

    Acknowledgment

    References

    Chapter 8. Marine Resource: A Promising Future for Anticancer Drugs

    Introduction

    Marine Macroorganisms

    Marine Microorganism

    Symbionts

    Conclusion

    References

    Chapter 9. 14β-Hydroxypregnanes from Succulent Plants Belonging to Hoodia gordonii and Caralluma Genus: Extraction, Biological Activities, and Synthesis

    Introduction

    Isolation of 14β-Hydroxypregnane Glycosides from Caralluma Species

    Isolation of 14β-Hydroxypregnane Glycosides from H. gordonii

    Biological Activities

    Synthetic Approaches to the Aglycones of 14β-Hydroxypregnane Glycosides

    Synthesis of Hoodigogenin A and P57

    Conclusion

    References

    Chapter 10. Chemico-Biological Aspects of Plant Lectins with a Preference to Legume Lectins

    Abbreviations

    Introduction

    Classification of Plant Lectins

    Isolation of Plant Lectins

    Legume Lectins

    Structure–Activity Relationship in Legume Lectins

    Synthetic Glycoconjugates and Interactions with Lectins

    Legere to Lectinomics

    References

    Chapter 11. Lycopene: A Review of Chemical and Biological Activity Related to Beneficial Health Effects

    Abbreviations

    Introduction

    Lycopene: Chemistry, Metabolism, and Bioavailability

    Sources of Lycopene

    Lycopene Mechanisms of Action

    Beneficial Health Effects of Lycopene

    Lycopene Analysis

    Conclusions and Future Prospects

    Acknowledgments

    References

    Chapter 12. Oleuropeic and Menthiafolic Acid Glucose Esters from Plants: Shared Structural Relationships and Biological Activities

    Abbreviations

    Introduction

    Oleuropeyl and Menthiafoloyl Glucose Esters

    Biological Activities

    Functional Roles in Plants

    Biosynthesis

    Concluding Remarks

    Acknowledgement

    References

    Chapter 13. Pharmacological Effects of Cordyceps and Its Bioactive Compounds

    Introduction

    Pharmacological Studies

    Active Components

    Quality Control

    Conclusions

    Acknowledgment

    References

    Chapter 14. Silymarin Flavonolignans: Structure–Activity Relationship and Biosynthesis

    Abbreviations

    Introduction

    Chemistry and Composition of Milk Thistle Extract

    Stereochemistry of Flavonolignans

    Biosynthesis of Silymarin Flavonolignans

    Regulation of Flavonolignan Metabolic Pathway

    Biological Effects of Silymarin Flavonolignans

    Structure–Activity Relationship

    Conclusion

    References

    Chapter 15. Natural Antioxidants in Cosmetics

    Abbreviations

    Introduction

    Free Radicals and Reactive Oxygen Species

    Skin Defense Mechanism

    Natural Antioxidants

    Application of Antioxidants in Cosmetics

    Antioxidant Capacity; Methods of Determination and Quality Control

    Concluding Remarks

    Acknowledgments

    References

    Index

Product details

  • No. of pages: 538
  • Language: English
  • Copyright: © Elsevier 2013
  • Published: June 25, 2013
  • Imprint: Elsevier
  • eBook ISBN: 9780444626325

About the Series Editor

Atta-ur Rahman

Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan.

Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions.

He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011.

He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal Minister of Education (2002) and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. The Austrian government also honoured him with its highest civil award ("Das Große Goldene Ehrenzeichen am Bande", 2007) in recognition of his eminent contributions.

Prof. Atta-ur-Rahman was the Coordinator General of COMSTECH, an OIC Ministerial Committee comprising the 57 Ministers of Science & Technology from 57 OIC member countries during 1996-2012. He is also the Patron of International Centre of Chemical and Biological Sciences (which comprises a number of institutes, including the Hussain Ebrahim Jamal Research Institute of Chemistry and the Dr. Panjwani Center of Molecular Medicine and Drug Development) at Karachi University.

He established a research center on Genomics in Karachi University. In recognition of the eminent contributions of Prof. Atta-ur-Rahman, a number of institutions have been named after him within and outside Pakistan. These include a natural product chemistry institute (Atta-ur-Rahman Research Institute of Natural Product Discovery, RiND) at the University of Technology Mara in Malaysia, Atta-ur-Rahman School of Applied Biosciences at National University of Science & Technology in Islamabad, and Dr. Atta-ur-Rahman Building at the International Centre for Chemical and Biological Sciences, University of Karachi. The Academy of Sciences in the Developing World (TWAS) based in Trieste, Italy has introduced a Dr. Atta-ur-Rahman Prize in Chemistry to a scientist from the developing world each year. The Prize carries a cash award of $ 5,000 and a Certificate.

Affiliations and Expertise

University of Karachi, Pakistan

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