Studies in Natural Products Chemistry, Volume 40

1st Edition

Hardcover ISBN: 9780444596031
eBook ISBN: 9780444626325
Imprint: Elsevier
Published Date: 2nd July 2013
Page Count: 538
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Table of Contents

Contributors

Preface

Chapter 1. Recent Insights into the Emerging Role of Triterpenoids in Cancer Therapy: Part I

Abbreviations

Introduction

Mechanisms of the Antitumor Effect of Triterpenoids

Concluding Remarks

References

Chapter 2. Recent Advances in Medicinal Applications of Brassinosteroids, a Group of Plant Hormones

Abbreviations

Introduction

Source of BRs

Toxicity of BRs

Similarity of BRs to Animal Steroid Hormones

Anabolic Effect of BRs

Anticancer and Antiproliferative Properties of BRs

Antiangiogenic Properties of BRs

Antiviral Properties of BRs

Neuroprotective Action of BRs

Concluding Remarks

References

Chapter 3. Synthesis of Bioactive Natural Products by Propargylic Carboxylic Ester Rearrangements

Introduction

Synthesis of Bioactive Natural Products by Rearrangement of Propargylic Esters via 1,2-Acyl Migration

Synthesis of Bioactive Natural Products by Rearrangement of Propargylic Esters via 1,3-Acyl Migration: [3,3]-Sigmatropic Rearrangement of Propargylic Esters

Conclusions

Acknowledgments

References

Chapter 4. Catalytic Asymmetric Strategies for the Synthesis of 3,3-Disubstituted Oxindoles

Introduction

Strategies Based on Cyclization Reactions for the Construction of the Lactam Ring

Asymmetric Rearrangements of O-Carbonylated Oxindoles and Related Processes

3-Substituted Oxindoles as Nucleophiles: Alkylation, Conjugate Addition, Aldol, and Mannich Reactions

Addition of Carbon Nucleophiles to Isatins or to Isatin Imines

Asymmetric Michael Additions to Isatin-Derived Electron-Deficient Alkenes and Related Processes

Amination, Hydroxylation, and Halogenation Reactions of 3-Substituted Oxindoles

Nucleophilic Substitution Reactions of Functionalized 3-Substituted


Description

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.

The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

Key Features

  • Describes the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • A valuable resource for natural products and medicinal chemistry

Readership

Natural product chemists, medicinal chemists, pharmacologists as well as researchers particularly those in academia and in the pharmaceutical industry


Details

No. of pages:
538
Language:
English
Copyright:
© Elsevier 2013
Published:
Imprint:
Elsevier
eBook ISBN:
9780444626325
Hardcover ISBN:
9780444596031

Reviews

Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.

The series also covers the synthesis or testing and recording of the medicinal properties of natural products.