Studies in Natural Products Chemistry

Studies in Natural Products Chemistry

1st Edition - February 26, 2022

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  • Editor: Atta-ur-Rahman
  • Hardcover ISBN: 9780128239445
  • eBook ISBN: 9780128239452

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Description

Studies in Natural Products Chemistry, Volume 72 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts on fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then rapidly determine the structures and biological activity of natural products, hence the importance of this book.

Key Features

  • Focuses on the chemistry of bioactive natural products
  • Contains contributions by leading authorities in the field
  • Presents sources of new pharmacophores

Readership

Natural product chemists working in academia and industry, medicinal chemists and pharmacologists in academia and industry

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Studies in Natural Products Chemistry
  • Copyright
  • Contributors
  • Preface
  • Chapter 1. Potentials of natural antioxidants from plants as antiosteoporotic agents
  • Introduction
  • Overview of NRF2/KEAP1 system
  • Phenylpropanoids as potential multitarget drugs to treat osteoporosis
  • Stilbenoids as potential multitarget drugs to treat osteoporosis
  • Lignans as potential multitarget drugs to treat osteoporosis
  • Coumestans as potential multitarget drugs to treat osteoporosis
  • Isoflavonoids as potential multitarget drugs to treat osteoporosis
  • Flavonoids as potential multitarget drugs to treat osteoporosis
  • Terpenoids as potential multitarget drugs to treat osteoporosis
  • Isothiocyanate as potential multitarget drugs to treat osteoporosis
  • Concluding remarks
  • Abbreviations
  • Chapter 2. Recent advances in extraction, isolation, characterization, and applications of phenolic compounds
  • Introduction
  • Categories of phenolics
  • Properties affecting extraction, separation, and fractionation of phenolic compounds
  • Current scenario and novel extraction and isolation techniques
  • Identification and characterization techniques
  • Novel applications of phenolic compounds
  • Current scenario and future trend in the research on phenolics
  • Conclusion
  • Chapter 3. Analytical approaches used in the profiling of natural products with a therapeutic target: a global perspective on nutrition and health
  • Introduction
  • Phytochemical compounds
  • Separation and purification methods
  • Conclusion
  • Chapter 4. Separation procedures for complicated mixtures of sea cucumber triterpene glycosides with isolation of individual glycosides, their comparison with HPLC/MS metabolomic approach, and biosynthetic interpretation of the obtained structural data
  • Introduction
  • The usage of metabolomic approach to the investigations of triterpene glycosides from the sea cucumbers
  • The methodology used for the isolation of triterpene glycosides from the sea cucumbers of the orders Holothuriida, Synallactida, and Persiculida (earlier included to the order Aspidochirotida). The comparison with results obtained by metabolomic studies
  • The separation methodology applied for the isolation of glycosides from the sea cucumbers of the order Dendrochirotida
  • Comparison of the data obtained by MS-based metabolic profiling of triterpene glycosides of the sea cucumber Eupentacta fraudatrix with the data obtained as a result of applying of the separation approach
  • The metabolic networks constructed on the base of biogenetic analysis of the carbohydrate chain structures of the glycosides isolated from the sea cucumbers Cladolabes schmeltzii and Psolus fabricii
  • General scheme of biosynthesis of the aglycones of different structural types, constructed on the base of structural and biogenetic analysis of isolated glycosides
  • Conclusion
  • Chapter 5. Structure-activity relationship studies on anti-cancer bioactive natural products
  • Introduction
  • Triterpenes and triterpenoids
  • Ursane triterpenoid derivatives
  • Sesquiterpenes
  • Bisabolanes
  • Glycosides
  • Alkaloids
  • Steroids
  • Methylcoumarin derivatives
  • Sesquiterpene lactones
  • Conclusion
  • Chapter 6. Centrifugal partition chromatography isolation of glaucolides sesquiterpenes and LC-ESIMS/MS technique for differentiation the mass spectrometry behavior of hirsutinolide and glaucolide skeletons
  • Introduction
  • Comparison of the sesquiterpene lactones profile of some Asteraceae species (Table 6.1)
  • Mass spectrometry behavior as a strategy for differentiating glaucolide and hirsutinolide in liquid chromatography analysis
  • Differentiation strategy application for monitoring glaucolide transformations
  • Countercurrent chromatographic techniques: a solid support-free alternative for sesquiterpene lactones purification
  • Solvents system formulation
  • Isolation of sesquiterpene lactones by countercurrent chromatographic techniques
  • Isolation of sesquiterpene lactone glaucolide subtype by centrifugal partition chromatographic
  • Final considerations
  • Chapter 7. Cytochrome P450 and P-gp mediated herb–drug interactions of some common Indian herbs
  • Introduction
  • Conclusion
  • Chapter 8. Hepatoprotective potential of bioflavonoids
  • Introduction to liver
  • Hepatic diseases
  • Treatment of hepatic diseases
  • Plants and their phytochemicals used in hepatic diseases
  • Bioflavonoids with hepatoprotective activity
  • Conclusion
  • Abbreviations
  • Chapter 9. Biological activity and 13C NMR spectral data of iboga-type skeleton alkaloids
  • Introduction
  • IBOGA-TYPE skeleton alkaloids—species and biological activities
  • Details of biological activities
  • Iboga-Type skeleton alkaloids—structures
  • Concluding remarks
  • Chapter 10. Isolation, elucidation, and structure–activity relationships of phytoalkaloids from Solanaceae
  • Introduction
  • Alkaloids and Solanaceae plants
  • General methods of extraction and isolation of alkaloids
  • Tropane alkaloids
  • Classification of tropane alkaloids
  • Structure–activity relationships of tropane derivatives
  • Chemical structural elucidation of atropine
  • Structure of tropic acid
  • Structure of tropine (C8H15NO)
  • Pyrrolidine–pyridine alkaloids
  • Conclusion
  • Chapter 11. Food bioactives: the food image behind the curtain of health promotion and prevention against several degenerative diseases
  • Introduction
  • Food bioactives
  • Polyphenols
  • Flavonoids
  • Terpenoids
  • Saponins
  • Carotenoids
  • Alkaloids
  • Bioactive peptides
  • Polyunsaturated fatty acids
  • Food and food products as sources of bioactive compounds
  • Degenerative diseases
  • Diabetes
  • Cardiovascular diseases
  • Rheumatoid arthritis
  • Obesity
  • Cancer
  • Huntington's disease
  • Alzheimer's disease
  • Parkinson's disease
  • Cytotoxicity of food bioactives
  • Conclusion
  • Chapter 12. Natural products for controlling dengue and its vectors
  • Introduction
  • Natural products as antiviral agents against dengue virus
  • Natural products as larvicidal agents against Aedes sp. mosquitoes
  • Mosquitocidal and Repellent activities
  • Conclusion
  • Chapter 13. The biological activities of marine macroalgae from the eastern Mediterranean Sea
  • Introduction
  • The biological activities of marine macroalgae in the eastern Mediterranean Sea
  • Conclusion
  • Index

Product details

  • No. of pages: 506
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: February 26, 2022
  • Imprint: Elsevier
  • Hardcover ISBN: 9780128239445
  • eBook ISBN: 9780128239452

About the Editor

Atta-ur-Rahman

Atta-ur-Rahman
Atta-ur-Rahman, Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan, was the Pakistan Federal Minister for Science and Technology (2000-2002), Federal Minister of Education (2002), and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. He is a Fellow of the Royal Society of London (FRS) and an UNESCO Science Laureate. He is a leading scientist with more than 1283 publications in several fields of organic chemistry.

Affiliations and Expertise

Professor Emeritus, International Center for Chemical and Biological Sciences (H. E. J. Research Institute of Chemistry and Dr. Panjwani Center for Molecular Medicine and Drug Research), University of Karachi, Pakistan

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