Structure to Function of G Protein-Gated Inwardly Rectifying (GIRK) Channels, Volume 123

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• Preface
• Chapter One: Unifying Mechanism of Controlling Kir3 Channel Activity by G Proteins and Phosphoinositides
  • Abstract
  • 1 Introduction
  • 2 Regulation of KACh by G Proteins
  • 3 Molecular Constituents of Kir3 Channels and Physiological Roles
  • 4 Dependence of KACh Channel Activity on PIPs
  • 5 Physiological Significance of Distinct Membrane-Delimited Signaling Mechanisms
  • 6 Molecular Mechanism of PIP2 Control of Kir Channel Gating
  • 7 Posttranslational Modification Can Control Activity Through Changes in Channel–PIP2 Interactions
  • 8 The Kir3 Channel Site of Gβγ Action
• Chapter Two: The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels
  • Abstract
  • 1 Introduction
  • 2 Interaction of Gα and Gβγ With GIRK
  • 3 Roles of Gβγ and Gα in GIRK's Evoked and Basal Activity
  • 4 Basal Activity of GIRKs
  • 5 Multimolecular Signaling Complex and the Mechanism of GIRK Activation
  • Acknowledgments
• Chapter Three: RGS Redundancy and Implications in GPCR–GIRK Signaling
  • Abstract
  • 1 RGS Proteins—Background and Significance
  • 2 Direct “Membrane-Delimited” GPCR-to-Ion Channel Signaling
  • 3 RGS Actions on GPCR–GIRK Channel Gating Kinetics
  • 4 RGS Functional Redundancy—Emerging Evidence from Retinal Neurons
  • 5 RGS Functional Redundancy in Neuronal GPCR–GIRK Channel Signaling
  • 6 RGS Functional Redundancy in Cardiac GPCR-GIRK Channel Signaling
  • 7 RGS Actions on Gq-Mediated Changes in GIRK Channel Activity
  • 8 Conclusions
• Chapter Four: Structural Insights into GIRK Channel Function
  • Abstract
  • 1 Introduction
  • 2 Selectivity and Permeation
  • 3 Rectification
  • 4 Gating
  • 5 Conclusions
  • Acknowledgments
• Chapter Five: Localization and Targeting of GIRK Channels in Mammalian Central Neurons
  • Abstract
  • 1 Introduction
  • 2 Molecular Organization and Heterogeneity of GIRK Channels
  • 3 Neuroanatomical Approaches to the Study of GIRK Channel Distribution
  • 4 Regional Distribution of GIRK Channel Subunits in the CNS
  • 5 Cellular Distribution of GIRK Channel Subunits
  • 6 Subcellular Distribution of GIRK Channel Subunits
  • 7 Developmental Aspects of GIRK Channel Distribution
  • 8 Conclusions and Future Perspectives
  • Acknowledgments
• Chapter Six: GIRK Channel Plasticity and Implications for Drug Addiction
  • Abstract
  • 1 Introduction
  • 2 GIRK Channels in the Mesocorticolimbic System
  • 3 Drug-Dependent Plasticity of GIRK Channel-Dependent Signaling
  • 4 Mechanisms Underlying the Plasticity of GIRK Channel-Dependent Signaling
  • 5 Concluding Thoughts and Future Directions
  • Acknowledgments
• Chapter Seven: GIRK Channels: A Potential Link Between Learning and Addiction
  • Abstract
  • 1 Introduction
  • 2 GIRK Channels
  • 3 GIRK Channel Modulation by Drugs of Abuse
  • 4 Neuronal Plasticity
  • 5 Summary and Future Directions
• Chapter Eight: Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction
  • Abstract
  • 1 Introduction
  • 2 GIRK Channels in CNS Disorders
  • 3 GIRK Channels in Addiction
  • 4 Therapeutic Potential of GIRK Channel Modulators
  • 5 Concluding Remarks and Future Directions
  • Acknowledgments
• Index
• Contents of recent volumes

This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field.

• Presents a comprehensive overview of the latest research into GIRK potassium channels
• Serves as a perfect starting point for researchers and practitioners entering the field
• Expands the literature and field of neurobiology

People working in basic neuroscience, neurology and psychiatry; medical doctors and care givers.