Structure–Function Relationships of Proteolytic Enzymes

Structure–Function Relationships of Proteolytic Enzymes

Proceedings of the International Symposium, Copenhagen June 16-18, 1969, No. 37 in the Series of the International Union of Biochemistry Sponsored Symposia

1st Edition - January 1, 1970

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  • Editors: P. Desnuelle, H. Neurath, M. Ottesen
  • eBook ISBN: 9781483261171

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Structure–Function Relationships of Proteolytic Enzymes provides information pertinent to the fundamental aspects of proteolytic enzymes. This book presents the historical role of proteolytic enzyme as a group in protein and enzyme chemistry. Organized into 23 chapters, this book begins with an overview of the results obtained from investigation on the chymotrypsinogens of porcine origin. This text then examines the differences of amino acid sequence between chymotrypsin, trypsin, and elastase that affect the substrate binding site, which reflect the specificity differences between these enzymes. Other chapters consider the kinetic parameters related to the trypsin-catalyzed hydrolysis of several model peptides. This book discusses as well the acetylation of trypsin, which result in functional consequences varying from complete inactivation to promotion of activity. The final chapter deals with the physical properties of stem bromelain in comparison with the data for three other sulfhydryl proteases of plant origin. This book is a valuable resource for enzymologists, microbiologists, and biochemists.

Table of Contents

  • List of Participants


    Session I: Pancreatic Proteases

    On the Three Chymotrypsinogens of Porcine Pancreas



    Chymotrypsin: Tertiary Structure and Enzymatic Activity (Abstract)



    The Role of Carboxylates and Phenol Side-Chains in the Activity and Conformation of Trypsinogen, Trypsin, Chymotrypsinogen, and Chymotrypsin

    Chemical Modifications of Bovine Trypsinogen and Trypsin

    The Specificity Site of Trypsin


    Structure and Mechanism of Action of a Pancreatic Trypsin Inhibitor

    The Chemistry of the Reactive Site of Soybean Trypsin Inhibitor

    Structural Aspects of Interaction of Trypsin with Macromolecular Inhibitors

    Homology and Phylogeny of Proteolytic Enzymes



    Structural Aspects of Thrombin and Prothrombin

    Cobalt Proteases: Implications of Absorption and Circular Dichroism Spectra for Catalysis

    Session II: Microbial Proteases

    Some Structure-Function Relationships in the Subtilisins

    Subtilisin BPN': Tertiary Structure and Inhibitor Binding (Abstract)


    Subtilisin: Stability Properties and Secondary Binding Sites


    Aminopeptidases from Thermophilic Microorganisms

    The Second Kaj Linderstrom-Lang Gold Medal Lecture

    A Synthetic Approach to the Study of Microenvironmental Effects on Enzyme Action

    Session III: Pepsin and Related Enzymes

    Specificity and Mechanism of Pepsin Action


    Towards a Mechanism for Pepsin



    Chemical Studies on Purified Pepsin

    Porcine Pepsinogen and Pepsin


    Session IV: Sulfhydryl Proteases

    The Three-Dimensional Structure of Papain

    Streptococcal Proteinase

    Structure and Function of Stem Bromelain

Product details

  • No. of pages: 310
  • Language: English
  • Copyright: © Academic Press 1970
  • Published: January 1, 1970
  • Imprint: Academic Press
  • eBook ISBN: 9781483261171

About the Editors

P. Desnuelle

H. Neurath

M. Ottesen

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