Structure and Function of Sarcoplasmic Reticulum

Structure and Function of Sarcoplasmic Reticulum

1st Edition - January 1, 1985

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  • Editors: Sidney Fleischer, Yuji Tonomura
  • eBook ISBN: 9781483277448

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Structure and Function of Sarcoplasmic Reticulum is a compendium of papers from an International Conference on Sarcoplasmic Reticulum held in Japan on November 1-4, 1982. Section I is a review of sarcoplasmic reticulum including the "discovery" of the relaxing factor, the calcium binding of relaxing factor, as well as phosphate transfer and calcium transport coupling. Section II involves the chemistry and structure of the calcium pump protein in sarcoplasmic reticulum. One paper describes the role of protein-lipid interactions in the organization and function of biomembranes. Section III considers the kinetics and thermodynamics of the calcium pumping mechanism, particularly the binding of ligands to calcium ATPase of the sarcoplasmic reticulum, as well as the conformational changes of the sarcoplasmic reticulum Ca-ATPase induced by substrate binding and phosphorylation. A paper gives the results of several experimental techniques in substrates binding assays employing millipore filters and a thermostated filtration apparatus. Section IV describes the calcium ions release process such as rapid and reversible actions, while Section V discusses the regulation of calcium ions uptake and release in the ion channel vesicles. This book can be helpful for researchers in biophysical engineering, pharmacologists, and scientists in the fields of biochemistry and biophysics.

Table of Contents

  • Contributors


    Yuji Tonomura (1923—1982)

    Section I Historical Background and Overview

    Relaxing Factor, Sarcoplasmic Reticulum, and Troponin - A Historical Survey

    The Sarcoplasmic Reticulum Calcium Pump: Early and Recent Developments Critically Overviewed

    Section II Chemistry and Ultrastructure of the Calcium Pump Protein in Sacroplasmic Reticulum

    Static and Time-Resolved Structural Studies of the Ca2 + -ATPase of Isolated Sarcoplasmic Reticulum

    Conformational Changes of Ca2+,Mg2+-Adenosinetriphosphatase as Detected by Site-Specifically Introduced Fluorescent andParamagnetic Probes and by Susceptibility to Tryptic Digestion

    Structural Analysis of the Ca2+,Mg2+-ATPase of Sarcoplasmic Reticulum

    Protein-Lipid Interaction in Sarcoplasmic Reticulum and Phospholipid-Replaced Membranes

    Sarcoplasmic Reticulum and Other Membranes in the Regulation of Skeletal Muscle Contraction and Relaxation: A Multilevel Approach

    A New Procedure for the Reconstitution of Sarcoplasmic Reticulum Vesicles by Salting-Out Method

    Target Size of Calcium Pump Protein from Skeletal Muscle Sarcoplasmic Reticulum

    Oligomeric Form of the Ca2+,Mg2+-Dependent ATPase in Sarcoplasmic Reticulum

    Section III Kinetics and Thermodynamics of the Calcium Pumping Mechanism

    A. Thermodynamic and Kinetic Considerations

    Binding of Ligands to Calcium ATPase of the Sarcoplasmic Reticulum

    Equilibrium and Kinetic Correlations of the Partial Reactions of the Ca2 + Transport Cycle

    Kinetic and Thermodynamic Aspects of ATP-Dependent Ca2+ Transport in Sarcoplasmic Reticulum Using ATPßS Diastereomers as Substrates

    Conformational Changes of the Sarcoplasmic Reticulum Ca-ATPase Induced by Substrate Binding and Phosphorylation

    Conformational Change of SR-ATPase Induced by Phosphorylation

    Mechanism for the Interconversion of Chemical and Osmotic Free Energy

    B. Kinetic Studies of the Calcium Pumping Cycle

    Kinetics of Accumulation of the ADP-Sensitive and ADP-Insensitive Phosphoenzymes and Their Relationship to Ca2+ Translocation in Sarcoplasmic Reticulum

    Pre-Steady State Kinetics of E~P Formation and Decomposition by Ca2+,Mg2 + -ATPase in Bovine Aorta Microsomes

    Theoretical Basis for the Sequence Analysis of the Reaction Steps Involved in the Transphosphorylation Process of the Sarcoplasmic Ca + +-Transport ATPase

    Ca2 + -Ca2 + Exchange Mediated by the Membrane-Bound Ca2+,Mg2+-ATPase of Sarcoplasmic Reticulum Vesicles

    Reaction Mechanism of ATP Hydrolysis by Sarcoplasmic Reticulum with CaATP as a Substrate

    Mechanism of ATP Synthesis in Sarcoplasmic Reticulum

    The Ca-ATPase of Sarcoplasmic Reticulum Catalyses a Monovalent Cation (Na,K) Exchange

    Section IV The Ca2+ Release Process

    Rapid and Reversible Calcium Release from Sarcoplasmic Reticulum In Vitro

    Mechanism of Calcium Release from Sarcoplasmic Reticulum: Effect of Caffeine on Magnesium Binding to Fragmented Sarcoplasmic Reticulum from Bullfrog Skeletal Muscle

    Ca Releasing Action of Quercetin on the Sarcoplasmic Reticulum of Frog Skeletal Muscle

    The Effects of Adenine Nucleotide and External Ca2+ on Ca2+ Release from Fragmented Sarcoplasmic Reticulum in the Presence of Mg2

    Calcium-Induced Calcium Release from Fragmented Sarcoplasmic Reticulum

    Calcium Impulse

    Appraisal of the Hypothesis of the "Depolarization-Induced" Release of Calcium from the Sarcoplasmic Reticulum in Skinned Cardiac Cells from the Rat or Pigeon Ventricle

    The Calcium-Induced Calcium Release from the Sarcoplasmic Reticulum

    Section V Regulation of Ca2+ Uptake and Release

    Ion Channels of Sarcoplasmic Reticulum Vesicles and Calcium Release

    Regulation of Ca2+ Pumping in Heart Sarcoplasmic Reticulum

    Resolution of the Regulatory Systems of the Cardiac Sarcoplasmic Reticulum Ca2+,Mg2+ -ATPase


Product details

  • No. of pages: 626
  • Language: English
  • Copyright: © Academic Press 1985
  • Published: January 1, 1985
  • Imprint: Academic Press
  • eBook ISBN: 9781483277448

About the Editors

Sidney Fleischer

Affiliations and Expertise

Vanderbilt University, Nashville, Tennessee, U.S.A.

Yuji Tonomura

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