Structure and Function of Biological Membranes

Structure and Function of Biological Membranes

1st Edition - January 1, 1971

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  • Editor: Lawrence I. Rothfield
  • eBook ISBN: 9781483281964

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Structure and Function of Biological Membranes explains the membrane phenomena at the molecular level through the use of biochemical and biophysical approaches. The book is an in-depth study of the structure and function of membranes. It is divided into three main parts. The first part provides an overview of the study of the biological membrane at the molecular level. Part II focuses on the detailed description of the overall molecular organization of membranes. The third part covers the relationship of the molecular organization of membranes to specific membrane functions; discusses catalytic membrane proteins; presents the role of membranes in important cellular functions; and looks at the membrane systems in eukaryotic cells. Biochemists, cell physiologists, biologists, researchers, and graduate and postdoctoral students in the field of biology will find the text a good reference material.

Table of Contents

  • Contents

    List of Contributors



    1. Biological Membranes: An Overview at the Molecular Level



    Newer Approaches to the Study of Membrane Structure

    2. Physicochemical Probes of Membrane Structure


    I. Introduction

    II. Probes of Membrane Structure

    III. The Future


    3. Spin Labeling and Membrane Structure

    Abbreviations and Definitions

    I. Introduction

    II. Electron Spin Resonance Spectra of Nitroxide Free Radicals

    III. Spin Labels Useful in Membrane Studies

    IV. Applications to Model Membrane Systems

    V. Applications to Biological Membranes

    VI. Technical Innovations: Use of Small Computers

    VII. Advantages and Disadvantages of Spin Labeling


    4. The Molecular Organization of Biological Membranes

    I. Introduction

    II. Thermodynamics of Protein and Other Macromolecular Systems

    III. Thermodynamics of Membrane Systems

    IV. Some Structural Studies of Membrane Systems

    V. The Lipid-Globular Protein Mosaic Model and Membrane Function

    VI. Concluding Remarks


    5. The Concept of Periplasmic Enzymes


    I. Introduction

    II. Methods for Selective Release of Periplasmic Enzymes

    III. The Surface Structure of Normal E. coli, Spheroplasts, and Osmotically Shocked Cells

    IV. Enzymes That Appear to Be Periplasmic in Location

    V. Evidence for Periplasmic Localization of Enzymes

    VI. "Surface" Enzymes in Other Microorganisms

    VII. Speculations on the Function of Periplasmic Enzymes

    VIII. General Conclusions


    Structure-Function Relationships in Biological Membranes

    6. Enzyme Reactions in Biological Membranes


    I. Introduction

    II. Participation of Lipids in Membrane Enzyme Reactions

    III. Studies of Individual Enzymes

    IV. Regulation of the Activity of Membrane Enzymes: Some Speculations


    7. The Molecular Basis of Membrane Transport Systems


    I. Introduction

    II. The Lactose System

    III. The Phosphoenolpyruvate Phosphotransferase System and the Uptake of Carbohydrates

    IV. The Binding Proteins Associated with Bacterial Transport Systems

    V. The Transport System for Sodium and Potassium Ions

    VI. Na±Dependent Transport of Amino Acids and Sugars

    VII. Discussion


    8. The Role of Membranes in the Synthesis of Macromolecules


    I. Introduction

    II. Synthesis of Cell Wall Polymers

    III. Biosynthesis of Proteins and Glycoproteins

    IV. Role of the Membrane in DNA Synthesis


    9. Structural and Functional Organization of Mitochondrial Membranes

    I. Introduction

    II. The Intact Mitochondrion

    III. Structure of the Outer Mitochondrial Menlbrane

    IV. Possible Functions of the Outer Mitochondrial Membrane

    V. Structure of the Inner Mitochondrial Membrane

    VI. Functions of the Inner Mitochondrial Membrane

    VII. The Relationship between Structure and Function of the Inner Mitochondrial Membrane


    10. Structure and Function of Surface Components of Mammalian Cells


    I. Introduction

    II. Glycoproteins and Glycolipids

    III. Surface Structures

    IV. Function of Cell Surface Carbohydrates


    Author Index

    Subject Index

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 1971
  • Published: January 1, 1971
  • Imprint: Academic Press
  • eBook ISBN: 9781483281964

About the Editor

Lawrence I. Rothfield

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