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Structure and Function of Biological Membranes - 1st Edition - ISBN: 9780125986502, 9781483281964

Structure and Function of Biological Membranes

1st Edition

Editor: Lawrence I. Rothfield
eBook ISBN: 9781483281964
Imprint: Academic Press
Published Date: 1st January 1971
Page Count: 500
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Structure and Function of Biological Membranes explains the membrane phenomena at the molecular level through the use of biochemical and biophysical approaches. The book is an in-depth study of the structure and function of membranes. It is divided into three main parts. The first part provides an overview of the study of the biological membrane at the molecular level. Part II focuses on the detailed description of the overall molecular organization of membranes. The third part covers the relationship of the molecular organization of membranes to specific membrane functions; discusses catalytic membrane proteins; presents the role of membranes in important cellular functions; and looks at the membrane systems in eukaryotic cells. Biochemists, cell physiologists, biologists, researchers, and graduate and postdoctoral students in the field of biology will find the text a good reference material.

Table of Contents


List of Contributors



1. Biological Membranes: An Overview at the Molecular Level



Newer Approaches to the Study of Membrane Structure

2. Physicochemical Probes of Membrane Structure


I. Introduction

II. Probes of Membrane Structure

III. The Future


3. Spin Labeling and Membrane Structure

Abbreviations and Definitions

I. Introduction

II. Electron Spin Resonance Spectra of Nitroxide Free Radicals

III. Spin Labels Useful in Membrane Studies

IV. Applications to Model Membrane Systems

V. Applications to Biological Membranes

VI. Technical Innovations: Use of Small Computers

VII. Advantages and Disadvantages of Spin Labeling


4. The Molecular Organization of Biological Membranes

I. Introduction

II. Thermodynamics of Protein and Other Macromolecular Systems

III. Thermodynamics of Membrane Systems

IV. Some Structural Studies of Membrane Systems

V. The Lipid-Globular Protein Mosaic Model and Membrane Function

VI. Concluding Remarks


5. The Concept of Periplasmic Enzymes


I. Introduction

II. Methods for Selective Release of Periplasmic Enzymes

III. The Surface Structure of Normal E. coli, Spheroplasts, and Osmotically Shocked Cells

IV. Enzymes That Appear to Be Periplasmic in Location

V. Evidence for Periplasmic Localization of Enzymes

VI. "Surface" Enzymes in Other Microorganisms

VII. Speculations on the Function of Periplasmic Enzymes

VIII. General Conclusions


Structure-Function Relationships in Biological Membranes

6. Enzyme Reactions in Biological Membranes


I. Introduction

II. Participation of Lipids in Membrane Enzyme Reactions

III. Studies of Individual Enzymes

IV. Regulation of the Activity of Membrane Enzymes: Some Speculations


7. The Molecular Basis of Membrane Transport Systems


I. Introduction

II. The Lactose System

III. The Phosphoenolpyruvate Phosphotransferase System and the Uptake of Carbohydrates

IV. The Binding Proteins Associated with Bacterial Transport Systems

V. The Transport System for Sodium and Potassium Ions

VI. Na±Dependent Transport of Amino Acids and Sugars

VII. Discussion


8. The Role of Membranes in the Synthesis of Macromolecules


I. Introduction

II. Synthesis of Cell Wall Polymers

III. Biosynthesis of Proteins and Glycoproteins

IV. Role of the Membrane in DNA Synthesis


9. Structural and Functional Organization of Mitochondrial Membranes

I. Introduction

II. The Intact Mitochondrion

III. Structure of the Outer Mitochondrial Menlbrane

IV. Possible Functions of the Outer Mitochondrial Membrane

V. Structure of the Inner Mitochondrial Membrane

VI. Functions of the Inner Mitochondrial Membrane

VII. The Relationship between Structure and Function of the Inner Mitochondrial Membrane


10. Structure and Function of Surface Components of Mammalian Cells


I. Introduction

II. Glycoproteins and Glycolipids

III. Surface Structures

IV. Function of Cell Surface Carbohydrates


Author Index

Subject Index


No. of pages:
© Academic Press 1971
1st January 1971
Academic Press
eBook ISBN:

About the Editor

Lawrence I. Rothfield

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