Structural Genomics, Part C - 1st Edition - ISBN: 9780123814432, 9780123814449

Structural Genomics, Part C, Volume 77

1st Edition

Serial Volume Editors: Andrzej Joachimiak
eBook ISBN: 9780123814449
Hardcover ISBN: 9780123814432
Imprint: Academic Press
Published Date: 9th December 2009
Page Count: 96
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Description

Structural genomics is the systematic determination of 3-D structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome.

While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large-scale cloning, expression and purification. One main advantage of this approach is economy of scale.

Key Features

  • Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy
  • Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists


Details

No. of pages:
96
Language:
English
Copyright:
© Academic Press 2009
Published:
Imprint:
Academic Press
eBook ISBN:
9780123814449
Hardcover ISBN:
9780123814432

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About the Serial Volume Editors

Andrzej Joachimiak Serial Volume Editor