Contributors
Preface
I Basic Mechanisms
1. A Tale of Three Peptides: Corticotropin-Releasing Factor-, Oxytocin-, and Vasopressin-Containing Pathways Mediating Integrated Hypothalamic Responses to Stress
I. Introduction
II. Effector Neuron Organization
III. Afferent Control
IV. Integration
References
2. Current Concepts in Hypothalamo-Pituitary-Adrenal Axis Regulation
I. Basal Regulation of the HPA Axis
II. Physiological Role of CRF and Vasopressin
III. Central Regulation of the HPA Axis
IV. Neural Pathways Mediating HPA Responses to Stimuli
V. Neurotransmitter Mechanisms of the Neural Control of the HPA Axis
VI. Feedback Regulation of the HPA Axis
VII. Summary
References
3. Amygdala: Role in Autonomic and Neuroendocrine Responses to Stress
I. Introduction
II. Anatomical and Functional Studies
III. Amygdala and Peptides
IV. Amygdala and Catecholamines
V. Amygdala and Neuroendocrine Responses
VI. Summary and Conclusions
References
4. Neuropeptides Involved in Stress and Their Distribution in the Mammalian Central Nervous System
Text
References
5. Neuropeptide-Mediated Regulation of the Neuroendocrine and Autonomic Responses to Stress
I. Introduction
II. Corticotropin-Releasing Factor
III. Thyrotropin-Releasing Factor
IV. Bombesin and Related Peptides
V. Somatostatin-Related Peptides
References
6. Corticotropin-Releasing Factor and Autonomic-Cardiovascular Responses to Stress
I. Introduction
II. CRF Neuronal Systems
III. CNS Actions of CRF
IV. Conclusions
References
7. Corticotropin-Releasing Factor, Stress, and Animal Behavior
I. Introduction
II. Centrally Administered CRF
III. Role of Endogenous CRF in Behavior
IV. Suggestions for Future Research
References
8. Methods of Measuring Neuropeptides and Their Metabolism
I. Introduction
II. Chromatographic Methods
III. Mass Spectrometric Methods
IV. Capillary Electrophoresis
V. Application to Measurements of Neuropeptide Metabolism
VI. Conclusions
References
II Endocrine Regulation
9. Stress, the Hypothalamic-Pituitary-Adrenal Axis, and Depression
I. Introduction
II. CRF and the Stress Response
III. CRF and Depression
IV. Summary
References
10. Use of Neuroendocrine Tests in the Psychiatric Assessment of the Medically Ill Patient
I. Introduction
II. Neuroendocrine Challenge Tests in Mood Disorders
III. Neuroendocrine Findings in Patients with Medical Illness and Mood Disorders
IV. Summary and Conclusions
References
III Immune Function
11. The Role of Stress and Opioids as Regulators of the Immune Response
I. Introduction
II. In Vitro Effect of Opioids on the Immune System
III. Do Immune Cells Produce Opioids?
IV. Physiological Regulation of NK Cells during Stress in Humans
V. Conclusion
References
12. Corticotropin-Releasing Factor Receptors in the Brain-Pituitary-Immune Axis
I. Introduction
II. CRF Receptors in Brain, Pituitary, and Spleen
III. Summary
References
13. Modulation of Immunity and Neoplasia by Neuropeptides Released by Stressors
I. The Concept of Stress
II. Stress, Immunity, and Cancer
III. Modulation of Immunity by Neuropeptides and Pituitary Hormones Released by Stressors
IV. Conclusions
References
14. Stress Responses and the Pathogenesis of Arthritis
I. Introduction
II. Depression and Arthritis
III. The Hypothalamic-Pituitary-Adrenal Axis: The Final Common Pathway of Stress
IV. Corticotropin-Releasing Hormone in the Major Depressive Syndromes: Potential Relevance to the Depression Associated with Rheumatoid Arthritis
V. Differential Function of the CRH Neuron in Subtypes of Depression
VI. HPA Axis-Immune System Interactions
VII. HPA Axis and Susceptibility to Arthritis
VIII. Summary
References
IV Gastrointestinal Function
15. Brain Peptides and Gastrointestinal Transit
I. Introduction
II. Opioids
III. Bombesin
IV. Corticotropin-Releasing Factor
V. Other Peptides
VI. Conclusion
References
16. Stress, Peptides, and Regulations of Ingestive Behavior
I. Introduction
II. Corticotropin-Releasing Factor and Consummatory Behaviors
III. Opioid-Induced Changes in Eating Behavior
IV. Other Regulations of Stress-Induced Eating
V. Effect of Stress on Consummatory Behavior in Humans
VI. Stress-Induced Consummatory Behaviors in Animals
VII. Conclusion
References
V Cardiovascular Regulation
17. Peptides Derived From ACTH and the N-Terminal Region of Pro-Opiomelanocortin in the Regulation of Central Autonomic Drive
I. Introduction
II. Hypertensive and Natriuretic Activities of ACTH(4-10)
III. Conformation-Activity Relationships of ACTH(4-10)
IV. Naturally Occurring Analogs of ACTH(4-10): Gamma MSH
V. Physiological Significance of Circulation Gamma MSH
VI. Conclusions
References
18. Atrial Natriuretic Factor Systems and Experimental Hypertension
I. Introduction
II. Dahl Salt-Sensitive and Salt-Resistant Rats
III. ANF Systems in Dahl Rats
IV. Spontaneously Hypertensive Rats
V. ANF Systems in Spontaneously Hypertensive Rats
VI. Summary and Conclusions
References
19. Stress, Opioid Peptides, and Cardiac Arrhythmias
I. Introduction
II. Endorphins and Receptors in Cardiovascular Control
III. Opioids and Arrhythmogenesis
IV. Baroreceptor Modulation and Opioids
V. Cellular Studies
VI. Peripheral Opioid Interactions
VII. Summary and Conclusion
References
20. The Role of Endogenous Opioids in Chronic Congestive Heart Failure
I. Introduction
II. The Endogenous Opioid System in a Canine Model of CHF
III. Effect of Opioids and Opioid Antagonists on Myocardial Contractility
IV. Studies of Opioid Antagonists in Humans with CHF
V. Implications and Future Directions
References
21. Diminished Opioid Inhibition of Blood Pressure and Pituitary Function in Hypertension Development
I. Introduction
II. Anatomical Distribution of Opioid Peptides and Receptors
III. Functional Significance of Opioid Mechanisms
IV. Opioids and Hypertension
V. A Model of Opioid Dysfunction in Hypertension Development
References
Index