Stress in Health and Disease

Stress in Health and Disease

1st Edition - January 1, 1976

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  • Author: Hans Selye
  • eBook ISBN: 9781483192215

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Description

Stress in Health and Disease presents the principal pathways mediating the response to a stressor. It discusses the clinical background of cross-resistance and treatment with stress-hormones. It addresses the diseases of adaptation or stress diseases, diagnostic indicators, and functional changes. Some of the topics covered in the book are the concept of heterostasis; stressors and conditioning agents; morphology of frostbite; characteristics manifestations of stress; catecholamines and their derivatives; various hormones and hormone-like substances; FFA, triglycerides and lipoproteins; morphologic changes; and hypothalamo-hypophyseal system . The gastrointestinal diseases of adaptation are covered. The schizophrenia and related psychoses is discussed. The text describes the manic-depressive disease and senile psychosis. A study of the experimental cardiovascular diseases and neuropsychiatric diseases is presented. A chapter is devoted to the diseases of adaptation in animals. Another section focuses on the shift in adenohypophyseal activity and catatoxic hormones. The book can provide useful information to scientists, doctors, students, and researchers.

Table of Contents


  • Foreword

    Purpose and Scope

    Prefatory Remarks on the Style of this Book

    General Structure

    References

    Critique and Personal Observations

    Reviews

    Our Earlier Stress Monographs

    General

    Popular

    Foreign Languages

    How to Use This Book

    Glossary

    Stress Tests

    I. History and General Outline of the Stress Concept

    History

    Prescientific Intuitive Feelings Foreshadowing the Existence of Stress

    Beginnings of a Scientific Analysis

    The General Adaptation Syndrome (G.A.S.)

    General Outline

    Definition and Terminology of Biologic Stress

    Principal Pathways Mediating the Response to a Stressor

    Conditioning

    Degrees of Specificity, Relationship between the G.A.S

    and L.A.S

    Cross Resistance and Treatment with Stressors or Stress Hormones

    The Diseases of Adaptation or Stress Diseases

    Syntoxic and Catatoxic Responses

    The Concept of Heterostasis

    Behavioral Implications

    II. Stressors and Conditioning Agents

    Trauma

    Generalities

    → ACTH and Corticoids

    → Catecholamines (EP, NEP)

    → STH

    → Insulin

    → Sex Hormones

    → Other Hormones

    → Histamine and 5-HT

    → Enzymes

    → Other Metabolites

    → Other Targets

    + Age

    + Anesthesia

    + Temperature

    + Season

    + Diet

    + Genetics

    Drugs

    AMP, ADP, ATP

    Alloxan

    Aminoglutethimide

    Amphenone

    Anesthetics and Analgesics

    Antiadrenergics

    Antibiotics

    Anticholinergics

    Antihistamines

    Asiaticoside

    Benzol

    Cannabis

    Chlorpromazine

    CNS Stimulants

    Colchicine

    Cysteamine

    DDD

    DDT

    DNA, RNA

    Dibenzyline

    Diphenylhydantoin

    DMSO

    DOPA

    Electrolytes, Water, Osmotic Pressure

    Ethanol

    Ethionine

    α-Ethyltryptamine, α-Methyltryptamine

    Formaldehyde

    Glucose

    6-Hydroxydopamine

    Insecticides

    Isethionate

    MAO Inhibitors

    Meprobamate

    Methadone

    Methamphetamine

    Metrazol

    Metyrapone (Metopirone)

    Morphine

    α-MT

    Mustards

    Narcotics and Other Psychotropic Drugs

    Nialamide

    Nicotine

    Nicotinic Acid

    Nitrous Oxide

    PCPA

    Pimozide

    Poly chlorinated Biphenyls

    Psychotropic Drugs

    Reserpine

    Ricin

    Salicylates

    Tranquilizers

    Vitamins

    Various Drugs or Drug Combinations Not Previously Mentioned

    Hormones and Hormone-like Substances

    Catecholamines

    Corticoids

    Glucagon

    Gonadotropic and Gonadal Hormones

    Histamine and 5-HT

    Insulin

    Pineal Hormones

    Renin, Angiotensin

    STH

    Thymus Hormones

    Thyroid Hormones

    Vasopressin.

    Diet

    Generalities

    → Hormones

    → Varia

    + Temperature Variations

    + Restraint

    + Other Stressors

    Physical Agents

    Temperature, including Frostbite

    Burns

    Sound

    Ultrasound, Sonic Booms

    Ionizing Rays

    Light Rays

    Ultraviolet Rays

    Vibration

    Air Blasts

    Compression, Decompression

    Gravity

    Electricity, Electroshock

    Magnetism

    Osmotic Pressure

    Microorganisms and Their Toxins

    Generalities

    → Hormones

    + Varia

    Immunity

    Hypoxia, Decreased Barometric Pressure including Hyperbaric Oxygenation

    Generalities

    → Morphology

    → Hormones

    → Enzymes and Other Metabolites

    → Nervous Changes

    → Varia

    + Varia

    Hemorrhage

    Muscular Exercise

    Generalities

    → Hormones

    → Enzymes and Other Metabolites

    + Varia

    Restraint

    Generalities

    → Hormones

    → Enzymes and Other Metabolites

    → Varia

    + Varia

    Athletics

    Generalities

    → Hormones

    + Varia

    Neuropsychologic Stimuli

    Generalities

    Pain and Grief

    Anxiety, Anticipation, Fear, Arousal

    Public Speaking

    Sleep Deprivation

    Motivation

    Cognition

    Fighting, Anger, Hate

    Sensory Deprivation, Boredom, Monotony

    Pleasure

    Handling and Gentling

    Varia

    Climate, Environment

    Generalities

    Pollution

    Social, Cultural, Family

    Crowding

    Isolation

    Captivity

    Concentration Camps, POWs

    Relocation and Travel

    Urbanization

    Catastrophe, Accidents

    Biorhythms

    Circadian

    Seasonal Variations

    Hibernation

    Meteorologic Influences

    Occupation

    Aerospace

    Parachute Jumping

    Air Traffic Control

    Navy, Marine, Submarine

    Diving

    Military Life, including Combat

    Automobile Driving

    Industry, Labor, Business, Finance

    Executive Life

    Medicine, Dentistry, Nursing

    Law

    Police Work

    Shift Work

    Telephone and Telegraph Operators

    Various Other Occupations

    Unemployment, Retirement

    Physiologic States

    Age

    Sex (Including the Sexual Cycle)

    Pregnancy and Lactation

    Genetics, Race, Constitution

    Generalities

    Vertebrates

    Mammals

    Birds

    Reptiles

    Amphibians

    Fish

    Invertebrates

    Plants and Microorganisms

    Tumors

    Combined Effect of Various Agents

    Multiple Stressors (Cross-resistance and Cross-sensitization)

    III. Characteristic Manifestations of Stress

    Chemical Changes

    Body Weight

    Basal Metabolic Rate (BMR)

    Other Metabolites

    Morphologic Changes

    Hypothalamo-hypophyseal System

    Adrenals

    Thyroid

    Sex Organs (including Pregnancy and Lactation)

    Pancreas

    Pineal Gland

    Thymicolymphatic and Hematopoietic Organs

    Blood Cells, Blood Volume

    Cardiovascular System

    Gastrointestinal System

    Oral (Teeth, Periodontal) Structures

    Salivary Glands

    Lung

    Ocular Structures

    Kidney

    Liver

    Connective Tissue, Wound Healing, Regeneration and Inflammation

    Skin

    Reticuloendothelial System (RES)

    Tumors

    Other Morphologic Changes

    Functional Changes

    Resistance

    Nervous System

    Stress Tests

    Body Temperature

    Cardiovascular System, including Blood Pressure, ECG

    Muscular System

    Blood Coagulation

    Immunology

    Death

    Varia

    IV. Diseases of Adaptation

    Generalities

    Shock

    Gastrointestinal Diseases of Adaptation

    Peptic Ulcers

    Experimental Peptic Ulcers

    Ulcerative Colitis

    Varia

    Cardiovascular Diseases (including Hypertension, Cardiac Infarcts, Periarteritis Nodosa)

    Generalities

    History

    ← Stressors in General

    ← Psychogenic Stressors

    ← Conditioning

    Diagnostic Indicators and Other Changes Characteristic of Stress-induced Cardiovascular Disease

    Experimental Cardiovascular Diseases

    Neuropsychiatric Diseases

    Generalities

    Psychosomatic

    Neuroses

    Schizophrenia and Related Psychoses

    Manic-depressive Disease

    Toxicomanias (including Alcoholism)

    Senile Psychosis

    Other Neuropsychiatric and Psychosomatic Diseases

    Experimental Neuroses (including Toxicomanias)

    Other Diseases of Adaptation

    Diabetes Mellitus

    Hypoglycemia and Hyperinsulinism

    Thyroid Diseases

    Cushing's Disease

    Immunity, Allergy and Infections

    Tumors

    Pancreatitis

    Renal Diseases

    Gynecologic Diseases

    Oral, Dental Diseases

    Ocular Diseases

    Skin Diseases

    Gastrointestinal Diseases

    Nutritional Diseases (including Kwashiorkor)

    Ménière's Disease

    Varia

    Pluricausal Diseases

    Diseases of Adaptation in Animals

    Generalities

    Shipping Fever

    Varia

    V. Treatment

    Generalities

    Rest and Leisure

    Psychotherapy in General

    Handling and Gentling

    Transcendental Meditation (TM) and Related Techniques

    Zen and Yoga

    Hypnosis

    Psychoanalysis

    Acupuncture and Moxibustion

    Chiropractic

    Osteopathy

    Various Stressors (Mental and Physical)

    Diet

    Hormones and Related Substances

    Vitamins

    Psychotropic Drugs in General

    Autonomic Blocking Agents

    Ginseng, Eleutherococcus

    Ethanol

    Other Drugs

    Smoking

    VI. Theories

    General Mechanisms

    Nervous Mechanisms

    Dictionary

    Anatomic Drawings and Explanatory Tables

    General Discussion of CRF and the Results of Experiments

    Deafferentation of the Hypophysiotrophic Area

    Abstracts of Literature on Various Nervous Mechanisms

    Hormonal Mechanisms

    Anterior Lobe of the Hypophysis

    Middle {Intermediate) Lobe of the Hypophysis, MTH (MSH)

    Posterior (Neural) Lobe of the Hypophysis

    Adrenals

    The Shift in Adenohypophyseal Activity

    Syntoxic and Catatoxic Hormones

    Other Hormones and Hormone-like Substances

    Various Mechanisms

    The First Mediator

    General Adaptation Syndrome (G.A.S.) vs Local Adaptation Syndrome (L.A.S.)

    Conditioning

    The Three Phases of the G.A.S., Adaptation Energy, Aging

    Stress and Fatigue

    Various Other Theories

    VII. Various Other Related Topics

    Legal Implications

    Philosophic Implications

    Institutes, Laboratories, and Societies Primarily or Exclusively Devoted to Stress Research

    Epilogue

    Author Index

    Subject Index


Product details

  • No. of pages: 1300
  • Language: English
  • Copyright: © Butterworth-Heinemann 1976
  • Published: January 1, 1976
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483192215

About the Author

Hans Selye

Ratings and Reviews

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  • Dr D. Tue Apr 07 2020

    the General adaptation syndrome by Hans Selye

    the book is a compilation of the experiences and inquiries of a medical mind of Dr Hans Selye since he was a medical student. He has thought on the patho - physiology of a disease in a totally different way , considering the role of learning and behaviour in the genesis of a disease , its course and outcome.