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Stress Genetics, Epigenetics and Genomics - 1st Edition - ISBN: 9780128131565

Stress Genetics, Epigenetics and Genomics

1st Edition

Volume 4: Handbook of Stress

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Editor: George Fink
Hardcover ISBN: 9780128131565
Imprint: Academic Press
Published Date: 1st November 2020
Page Count: 300
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This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases.
The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences.

Key Features

Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge
Richly illustrated with explanatory figures and tables
Each chapter includes a boxed “Key points” call out section
Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series


Neuroscientists, neuroendocrinologists, neurologists, neuropharmacologists, and researchers, graduate students, undergraduates, and post-doctoral fellows in neuroscience, psychology  and the biomedical sciences

Table of Contents

1. Genetic Factors and Stress
2. Genetic Polymorphisms in Stress Response
3. Genetic Testing and Stress
4. Genetic Mapping of Neuroticism
5. Neuroticism Response to Stress, Genetic Mapping of Mice
6. Genetic Predispositions to Stressful Conditions
7. Serotonin Transporter Genetic Modifications
8. Gene-Environment Interactions in Early Development
9. Stress and CNS Arousal: Genomic Contributions
10. Corticotropin Releasing Factor Receptor Deficiency in Mice
11. Corticosteroid Receptor Genes: Functional Dissection in Mice
12. Circadian Clock Genes as Modulators of Sensitivity to Genotoxic Stress
13. Mineralocorticoid Receptor Polymorphisms
14. Glucocorticoid Receptor Mutant Mice as Models for Stress-Induced Affective Disorders
15. Glucocorticoid Receptor Mutations and Polymorphisms
16. Genetic Variation of HPA Axis Activity and Function in Farm Animals
17. Strain Differences in Stress Response in Rodents
18. Drosophila Genes and Anoxia
19. Zebrafish as an emerging model for studying complex brain disorders
20. Expression Profiling of Stress Responsive Gene Patterns
21. MicroRNA effects on and control of stress response
22. The role of DNA methylation in stress-related psychiatric disorders
23. Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression
24. Stress Epigenetics: Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress
25. Stress Epigenetics: Understanding posttraumatic stress disorder: insights from the methylome
26. The dynamic genome: transposons and environmental adaptation in the nervous system
27. Moving through the Stressed Genome: Emerging Regulatory Roles for Transposons in Plant Stress Response
28. Maternal influences on stress response and vulnerability
29. Maternal deprivation
30. Transgenerational transmission of stress resilience and vulnerability
31. Gender and stress
32. Sex differences in human stress response


No. of pages:
© Academic Press 2021
1st November 2020
Academic Press
Hardcover ISBN:

About the Editor

George Fink

George Fink

Dr. Fink is Honorary Professor in the University of Melbourne and Professorial Research Fellow at the Florey Institute of Neuroscience and Mental Health. Formerly, he was Scientific Director of the Mental Health Research Institute, Melbourne, Australia. Before returning to Melbourne in 2003, Dr. Fink was University Lecturer in Human Anatomy and Fellow in Physiology and Medicine at Brasenose College and the University of Oxford and served for nearly 20 years as CEO and Director of the UK Medical Research Council’s Brain Metabolism Unit in Edinburgh. He gained distinction through his seminal research discoveries in neuroendocrinology and psychopharmacology published in over 360 scientific papers. Dr. Fink served as President of the European Neuroendocrine Association. His distinctions include Fellow of the Royal Society of Edinburgh, Fellow of the Royal College of Physicians of Edinburgh, Fellow of the Royal Biological Society, Fellow of the Physiological Society, and Honorary Member of the British Society for Neuroendocrinology. Fink was Honorary Professor in the University of Edinburgh, delivered the inaugural Geoffrey Harris Prize Lecture of the British Physiological Society, and the Wolfson Lecture. In 1979 he was awarded the Royal Society - Israel Academy Exchange Fellowship which enabled him to spend a research year at the Weizmann Institute of Science, Rehovot Israel. In 2000 he was awarded the Lifetime Achievement Award of the International Society of Psychoneuroendocrinology. His membership of learned societies includes Emeritus member of the Society for Neuroscience, the Endocrine Society and the Genetics Society of America. Dr. Fink has edited several scientific books with Elsevier, including Stress Science: Neuroendocrinology (2009), Stress Consequences: Mental, Neuropsychological and Socioeconomic (2009), Stress of War, Conflict and Disaster (2010), the Handbook of Neuroendocrinology (2011), and most notably the 4-volume second edition of the Encyclopedia of Stress (2007) on which this new Handbook of Stress series is based. He was founding Editor-in-Chief of the first edition of the Encyclopedia of Stress (2000) which was awarded the 2001 British Medical Association commendation for its contribution to Mental Health. The first volume of his Handbook of Stress series, entitled “Stress: Concepts, Cognition, Emotion, and Behavior”, received the BMA High Commendation in the Health and Social Care category as one of the top titles in its discipline.

Affiliations and Expertise

Professorial Research Fellow and Hon Professor, Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, Australia

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