Stress and Inflammation in Disorders - 1st Edition - ISBN: 9780128123881, 9780128123898

Stress and Inflammation in Disorders, Volume 108

1st Edition

Serial Editors: Rossen Donev
eBook ISBN: 9780128123898
Hardcover ISBN: 9780128123881
Imprint: Academic Press
Published Date: 17th April 2017
Page Count: 272
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Table of Contents

Chapter One: Oxidative Stress: Love and Hate History in Central Nervous System
Sánchez-González, A.L Sánchez-López, L. Sánchez-Romero, E.I Díaz-Barba, J.F. Santoscoy-Gutiérrez and P. Rivero-Moragrega

  • Abstract
  • 1 Introduction
  • 2 Oxidative Stress and Neuropathology
  • 3 PD and ROS
  • 4 Cerebral Ischemia and ROS
  • 5 Multiple Sclerosis

Chapter Two: Neuroinflammation in Alzheimer's Disease: The Preventive and Therapeutic Potential of Polyphenolic Nutraceuticals
Y. Sawikr, N.S. Yarla, I. Peluso, M.A. Kamal, G. Aliev and A. Bishayee

  • Abstract
  • 1 Introduction
  • 2 Neuroinflammation in AD (Alzheimer's Disease)
  • 3 Astrogliosis in AD
  • 4 Advanced Glycation End Products in AD
  • 5 Polyphenolic Nutraceuticals Targeting Neuroinflammation for Prevention and Therapy of AD
  • 6 Conclusions and Future Directions

Chapter Three: Inflammation in Epileptic Encephalopathies
O. Shandra, S.L. Moshé and A.S. Galanopoulou

  • Abstract
  • 1 Introduction
  • 2 Inflammation and Neuroinflammation: Definitions, Targets, and Role in Epilepsy and Seizures
  • 3 Does Activation of the Inflammatory Pathways in the Brain Cause Epilepsy in WS?
  • 4 Does Activation of the Inflammatory Pathways in the Brain Contribute to the Associated Comorbidities and Progression?
  • 5 Can Activation of Certain Inflammatory Pathways Be a Compensatory or Protective Event?
  • 6 Are There Interactions Between Inflammation and the Neuroendocrine System That Contribute to the Pathogenesis of WS?
  • 7 Does Activation of Brain Inflammatory Signaling Pathways Contribute to the Transition of WS to LGS?
  • 8 Are There Any Lead Candidates or Unexplored Targets for Future Therapy Development for WS Targeting Inflammation?
  • 9 Concluding Remarks
  • Acknowledgments

Chapter Four: Analyzing the Effect of V66M Mutation in BDNF in Causing Mood Disorders: A Computational Approach
P. Sneha, D. Thirumal Kumar, Sugandhi Saini, Kreeti Kajal, R. Magesh , R. Siva and C. George Priya Doss

  • Abstract
  • 1 Introduction
  • 2 Materials and Methods
  • 3 Results
  • 4 Discussion
  • 5 Conclusion
  • Acknowledgments

Chapter Five: A Computational Approach to Identify the Biophysical and Structural Aspects of Methylenetetrahydrofolate Reductase (MTHFR) Mutations (A222V, E429A, and R594Q) Leading to Schizophrenia
H. Tanwar, P. Sneha, D. Thirumal Kumar, R. Siva, C.E.J. Walter and C. George Priya Doss

  • Abstract
  • 1 Introduction
  • 2 Materials and Methods
  • 3 Results
  • 4 Discussion
  • 5 Conclusion
  • Acknowledgments

Chapter Six: Stress-Induced NLRP3 Inflammasome in Human Diseases
E. Alcocer-Gómez, B. Castejón-Vega and M.D. Cordero

  • Abstract
  • 1 Introduction
  • 2 Inflammatory Diseases and Stress
  • 3 The Inflammasomes
  • 4 The Inflammasome in the Psychiatric Diseases
  • 5 NLRP3 Inflammasome and Neuroinflammation in Neurodegenerative Diseases
  • 6 Inflammasome and Cancer
  • 7 NLRP3 and CVD
  • 8 Future Perspectives

Chapter Seven: Stress-Adaptive Response in Ovarian Cancer Drug Resistance: Role of TRAP1 in Oxidative Metabolism-Driven Inflammation
M.R. Amoroso, D.S Matassa, I. Agliarulo, R. Avolio, F. Maddalena, V. Condelli, M. Landriscina and F. Esposito

  • Abstract
  • 1 Introduction
  • 2 Linking OXPHOS, Inflammation, EMT, and Chemoresistance in Cancer
  • 3 TRAP1 as a Novel Player in Ovarian Cancer Biology
  • 4 Concluding Remarks

Chapter Eight: Molecular Targets of Ascochlorin and Its Derivatives for Cancer Therapy
J.M.-W. Chua, B.Y.-J. Chua, S. Mishra, X. Dai, J. Magae, S.-C. Ng, A.P Kumar and G. Sethi

  • Abstract
  • 1 Introduction
  • 2 Pharmacological Properties of ASC and Its Derivatives
  • 3 Anticancer Effects of ASC and Its Derivatives
  • 4 Conclusion
  • Acknowledgments

Chapter Nine: Cardiokines as Modulators of Stress-Induced Cardiac Disorders
A. Planavila, J. Fernández-Solà and F. Villarroya

  • Abstract
  • 1 Introduction
  • 2 The Heart as a Secretory Organ
  • 3 Cardiokines and Cardiac Stress
  • 4 Cardiokines: Autocrine/Paracrine Signaling
  • 5 Endocrine Functions of Cardiokines
  • 6 Cardiokines as Biomarkers for Cardiac Disorders
  • 7 Conclusions
  • Acknowledgments

Description

Stress and Inflammation in Disorders, Volume 108, the newest volume in this ongoing series, brings forth new information on protocols and analysis of proteins. This volume covers the latest on Oxidative Stress: Love and Hate History in the Central Nervous System, Neuroinflammation in Alzheimer's Disease: The Preventive and Therapeutic Potential of Polyphenolic Nutraceuticals, Inflammation in Epileptic Encephalopathies, A Computational Approach to Identify the Biophysical and Structural Aspect of Methylenetetrahydrofolate Reductase (MTHFR) Mutations (A222V, E429A and R594Q) Leading to Schizophrenia, and Analyzing the Effect of V66M Mutation in BDNF in Causing MOOD Disorders- A Computational Approach.

Each release in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics.

Key Features

  • Provides cutting-edge developments in protein chemistry and structural biology
  • Features new information about protocols and analysis of proteins
  • Contains chapters written by authorities in their respective fields
  • Targeted to a wide audience of researchers, specialists, and students

Readership

Researchers and specialists in protein structure and interactions, cancer biology, psychiatry and mass spectrometry


Details

No. of pages:
272
Copyright:
© Academic Press 2017
Published:
Imprint:
Academic Press
eBook ISBN:
9780128123898
Hardcover ISBN:
9780128123881

About the Serial Editors

Rossen Donev Serial Editor

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Lecturer in Swansea University. Currently he is Director of Biomed Consult Ltd, UK. His major research interests include signalling pathways involved in neuropsychiatric disorders and tumour escape from the immune system, and development of therapeutic strategies for treatment. He has published more than 50 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks at Attention Deficit/Hyperactivity Disorder meetings. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals.

Affiliations and Expertise

Swansea University, Swansea, Wales, UK