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Steroidal Activity in Experimental Animals and Man - 1st Edition - ISBN: 9781483230351, 9781483273006

Steroidal Activity in Experimental Animals and Man

1st Edition

Editor: Ralph I. Dorfman
eBook ISBN: 9781483273006
Imprint: Academic Press
Published Date: 1st January 1965
Page Count: 374
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Methods in Hormone Research, Volume IV: Steroidal Activity in Experimental Animals and Man, Part B focuses on protection against irradiation damage, anti-mammary tumor activity, anti-androgens, steroids, and anti-progestational compounds. The selection first offers information on the thermogenic properties of steroids and anabolic steroids, as well as characteristics of steroid pyrogen action in man; species specificity of steroid pyrogen action; clinical significance of thermogenic steroids; and relative activity of anabolic steroids in animals and man. The book also ponders on anti-androgens and anti-progestational compounds.
The manuscript examines steroids in reactivated prostatic cancer and tumorigenesis in experimental animals. Discussions focus on treatment and nature of relapse, cooperative study program, mammary and pituitary tumors, testicular interstitial cell tumors, and neoplasms of the female genital tract. The text then elaborates on inhibition of tumor growth by steroids and the effect of corticoids and ACTH on the induction of gastric ulcers in laboratory animals.
The selection is a dependable reference for readers interested in steroidal activity in man and animals.

Table of Contents


Contributors to Volume IV


Contents of Previous Volumes

1. Thermogenic Properties of Steroids

I. Introduction

II. Thermogenic Action of Progesterone

III. Steroid Pyrogens: C19 Series

IV. Steroid Pyrogens: C21 Series

V. Steroid Pyrogens : C24 Series

VI. Steroid Pyrogen Conjugates

VII. Species Specificity of Steroid Pyrogen Action

VIII. Characteristics of Steroid Pyrogen Action in Man

IX. Metabolism of Steroid Pyrogens

X. Mechanisms of Steroid Fever

XI. Clinical Significance of Thermogenic Steroids


2. Anabolic Steroids

I. Introduction

II. Relative Activity in the Animal

III. Relative Activity in Man


3. Anti-Androgens



4. Anti-Progestational Compounds



5. Steroids in Reactivated Prostatic Cancer

I. Treatment of Relapse

II. Experimental Prostatic Cancer

III. The Cooperative Study Program

IV. The Nature of Relapse

V. Summary and Conclusions


6. Steroids and Tumorigenesis in Experimental Animals

I . General Considerations

II. Mammary Tumors

III. Testicular Interstitial Cell Tumors

IV. Pituitary Tumors

V. Neoplasms of the Female Genital Tract

VI. Renal Tumors in the Hamster

VII. Lymphoid Tumors in Mice

VIII. Miscellaneous Considerations


7. Inhibition of Tumor Growth by Steroids



8. Effects of Steroids on the Pancreas

I. Introductory Information Concerning the Pancreas

II. Steroids and the Endocrine Pancreas

III. Effects of Steroids on the Exocrine Pancreas

IV. Summary


9. Effects of Corticoids and ACTH on the Induction of Gastric Ulcers in Laboratory Animals

I. Methodology

II. The Normal Stomach as Influenced by Corticoids and ACTH

III. Influence of Corticoids and ACTH on the Development of Artificial Gastric Ulcers

IV. Healing of Gastric Ulcers as Influenced by Corticoids and ACTH

V. Relation between Gastric and Other Effects of Corticoids

VI. Experimental Data and Clinical Features


10. The Influence of Steroids on β-Glucuronidase of Mouse Kidneys

I. Introduction

II. Renal β-Glucuronidase Response

III. Studies on Biological Mechanisms


Author Index

Subject Index


No. of pages:
© Academic Press 1965
1st January 1965
Academic Press
eBook ISBN:

About the Editor

Ralph I. Dorfman

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