Steroidal Activity in Experimental Animals and Man

1st Edition - January 1, 1965
Editor: Ralph I. Dorfman
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 7 3 0 0 - 6

Methods in Hormone Research, Volume IV: Steroidal Activity in Experimental Animals and Man, Part B focuses on protection against irradiation damage, anti-mammary tumor activity,… Read more

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Methods in Hormone Research, Volume IV: Steroidal Activity in Experimental Animals and Man, Part B focuses on protection against irradiation damage, anti-mammary tumor activity, anti-androgens, steroids, and anti-progestational compounds. The selection first offers information on the thermogenic properties of steroids and anabolic steroids, as well as characteristics of steroid pyrogen action in man; species specificity of steroid pyrogen action; clinical significance of thermogenic steroids; and relative activity of anabolic steroids in animals and man. The book also ponders on anti-androgens and anti-progestational compounds. The manuscript examines steroids in reactivated prostatic cancer and tumorigenesis in experimental animals. Discussions focus on treatment and nature of relapse, cooperative study program, mammary and pituitary tumors, testicular interstitial cell tumors, and neoplasms of the female genital tract. The text then elaborates on inhibition of tumor growth by steroids and the effect of corticoids and ACTH on the induction of gastric ulcers in laboratory animals. The selection is a dependable reference for readers interested in steroidal activity in man and animals.

Contents

Contributors to Volume IV

Preface

Contents of Previous Volumes

1. Thermogenic Properties of Steroids

I. Introduction

II. Thermogenic Action of Progesterone

III. Steroid Pyrogens: C19 Series

IV. Steroid Pyrogens: C21 Series

V. Steroid Pyrogens : C24 Series

VI. Steroid Pyrogen Conjugates

VII. Species Specificity of Steroid Pyrogen Action

VIII. Characteristics of Steroid Pyrogen Action in Man

IX. Metabolism of Steroid Pyrogens

X. Mechanisms of Steroid Fever

XI. Clinical Significance of Thermogenic Steroids

References

2. Anabolic Steroids

I. Introduction

II. Relative Activity in the Animal

III. Relative Activity in Man

References

3. Anti-Androgens

Text

References

4. Anti-Progestational Compounds

Text

References

5. Steroids in Reactivated Prostatic Cancer

I. Treatment of Relapse

II. Experimental Prostatic Cancer

III. The Cooperative Study Program

IV. The Nature of Relapse

V. Summary and Conclusions

References

6. Steroids and Tumorigenesis in Experimental Animals

I . General Considerations

II. Mammary Tumors

III. Testicular Interstitial Cell Tumors

IV. Pituitary Tumors

V. Neoplasms of the Female Genital Tract

VI. Renal Tumors in the Hamster

VII. Lymphoid Tumors in Mice

VIII. Miscellaneous Considerations

References

7. Inhibition of Tumor Growth by Steroids

Text

References

8. Effects of Steroids on the Pancreas

I. Introductory Information Concerning the Pancreas

II. Steroids and the Endocrine Pancreas

III. Effects of Steroids on the Exocrine Pancreas

IV. Summary

References

9. Effects of Corticoids and ACTH on the Induction of Gastric Ulcers in Laboratory Animals

I. Methodology

II. The Normal Stomach as Influenced by Corticoids and ACTH

III. Influence of Corticoids and ACTH on the Development of Artificial Gastric Ulcers

IV. Healing of Gastric Ulcers as Influenced by Corticoids and ACTH

V. Relation between Gastric and Other Effects of Corticoids

VI. Experimental Data and Clinical Features

References

10. The Influence of Steroids on β-Glucuronidase of Mouse Kidneys

I. Introduction

II. Renal β-Glucuronidase Response

III. Studies on Biological Mechanisms

References

Author Index

Subject Index