Steroidal Activity in Experimental Animals and Man

Steroidal Activity in Experimental Animals and Man

1st Edition - January 1, 1965

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  • Editor: Ralph I. Dorfman
  • eBook ISBN: 9781483273006

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Methods in Hormone Research, Volume IV: Steroidal Activity in Experimental Animals and Man, Part B focuses on protection against irradiation damage, anti-mammary tumor activity, anti-androgens, steroids, and anti-progestational compounds. The selection first offers information on the thermogenic properties of steroids and anabolic steroids, as well as characteristics of steroid pyrogen action in man; species specificity of steroid pyrogen action; clinical significance of thermogenic steroids; and relative activity of anabolic steroids in animals and man. The book also ponders on anti-androgens and anti-progestational compounds. The manuscript examines steroids in reactivated prostatic cancer and tumorigenesis in experimental animals. Discussions focus on treatment and nature of relapse, cooperative study program, mammary and pituitary tumors, testicular interstitial cell tumors, and neoplasms of the female genital tract. The text then elaborates on inhibition of tumor growth by steroids and the effect of corticoids and ACTH on the induction of gastric ulcers in laboratory animals. The selection is a dependable reference for readers interested in steroidal activity in man and animals.

Table of Contents

  • Contents

    Contributors to Volume IV


    Contents of Previous Volumes

    1. Thermogenic Properties of Steroids

    I. Introduction

    II. Thermogenic Action of Progesterone

    III. Steroid Pyrogens: C19 Series

    IV. Steroid Pyrogens: C21 Series

    V. Steroid Pyrogens : C24 Series

    VI. Steroid Pyrogen Conjugates

    VII. Species Specificity of Steroid Pyrogen Action

    VIII. Characteristics of Steroid Pyrogen Action in Man

    IX. Metabolism of Steroid Pyrogens

    X. Mechanisms of Steroid Fever

    XI. Clinical Significance of Thermogenic Steroids


    2. Anabolic Steroids

    I. Introduction

    II. Relative Activity in the Animal

    III. Relative Activity in Man


    3. Anti-Androgens



    4. Anti-Progestational Compounds



    5. Steroids in Reactivated Prostatic Cancer

    I. Treatment of Relapse

    II. Experimental Prostatic Cancer

    III. The Cooperative Study Program

    IV. The Nature of Relapse

    V. Summary and Conclusions


    6. Steroids and Tumorigenesis in Experimental Animals

    I . General Considerations

    II. Mammary Tumors

    III. Testicular Interstitial Cell Tumors

    IV. Pituitary Tumors

    V. Neoplasms of the Female Genital Tract

    VI. Renal Tumors in the Hamster

    VII. Lymphoid Tumors in Mice

    VIII. Miscellaneous Considerations


    7. Inhibition of Tumor Growth by Steroids



    8. Effects of Steroids on the Pancreas

    I. Introductory Information Concerning the Pancreas

    II. Steroids and the Endocrine Pancreas

    III. Effects of Steroids on the Exocrine Pancreas

    IV. Summary


    9. Effects of Corticoids and ACTH on the Induction of Gastric Ulcers in Laboratory Animals

    I. Methodology

    II. The Normal Stomach as Influenced by Corticoids and ACTH

    III. Influence of Corticoids and ACTH on the Development of Artificial Gastric Ulcers

    IV. Healing of Gastric Ulcers as Influenced by Corticoids and ACTH

    V. Relation between Gastric and Other Effects of Corticoids

    VI. Experimental Data and Clinical Features


    10. The Influence of Steroids on β-Glucuronidase of Mouse Kidneys

    I. Introduction

    II. Renal β-Glucuronidase Response

    III. Studies on Biological Mechanisms


    Author Index

    Subject Index

Product details

  • No. of pages: 374
  • Language: English
  • Copyright: © Academic Press 1965
  • Published: January 1, 1965
  • Imprint: Academic Press
  • eBook ISBN: 9781483273006

About the Editor

Ralph I. Dorfman

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