A Three-Dimensional Insight

1st Edition - July 21, 2021

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  • Authors: Anil Karnik, Mohammed Hasan
  • Paperback ISBN: 9780128210628
  • eBook ISBN: 9780128210635

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Stereochemistry: A Three-Dimensional Insight draws on the knowledge of its expert authors, providing a systematic treatment on the fundamental aspects of stereochemistry, covering conformational aspects, configurational aspects, effects of bulkiness, stereoelectronic effects on properties of molecules, and the genesis of enantiomerism, among other topics. Visuals and exercises are included to consolidate the principles learned, and the contents are carefully structured to prepare readers for predicting and organizing reaction components to obtain desired stereochemical outcomes. This book is an  indispensable guide for all those exploring stereochemistry within their work. The principles of stereochemistry are fundamental to understanding chemical behavior and can provide insights into a whole range of problems, from unusual selectivity and unexpected behaviors, to abnormally fast reactions and surprising biochemical preferences. However, understanding and exploring these 3D effects can be difficult within a 2D medium. This book has been designed to address this problem, providing foundational guidance on the principles and applications of stereochemistry that are fully supported by multimedia visuals.

Key Features

  • Combines foundational concepts and definitions with examples of stereochemistry in practice
  • Highlights the conformational and configurational impact of atomic arrangement on chemical behavior
  • Outlines methods of analysis
  • Provides practical exercises and detailed multimedia visuals to support learning


Graduate students, teachers, researchers and industrial chemists in the disciplines of organic chemistry, medicinal chemistry and biochemistry

Table of Contents

  • Part I Fundamentals of stereochemistry
    1. Basic concepts of structure and stereochemistry
    2. Symmetry and point groups
    3. Elements of chirality and chiral stereoisomerism

    Part II Enantiomer properties
    4. Chiroptical properties: Origin and applications
    5. Configurational analysis
    6. Racemates: Properties and methods of resolution

    Part III Conformations and conformational analysis
    7. Conformation of acyclic molecules
    8. Conformations of cyclic, fused and bridged ring molecules

    Part IV Stereochemical reactivity
    9. Prochirality
    10. Diastereomeric transition states and stereoselectivity
    11. Chiral analytical chemistry
    12. Pericyclic reactions

Product details

  • No. of pages: 620
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: July 21, 2021
  • Imprint: Elsevier
  • Paperback ISBN: 9780128210628
  • eBook ISBN: 9780128210635

About the Authors

Anil Karnik

Professor Anil V. Karnik is based at the Department of Chemistry, University of Mumbai, India, where he presently works as a UGC-BSR Fellow (Professor). He has taught stereochemistry and chirality related topics to post-graduate students for more than 30 year, and has delivered hundreds of lectures on various aspects of stereochemistry at different State Universities and colleges in India. His research area includes various fundamental aspects of stereochemistry, which has resulted in quality publications in reputed high impact factor international journals. His research areas include asymmetric organocatalysis, synthesis of sterically crowded biaryl and helical molecules, chiral molecular recognition, kinetic resolutions to name important few. He has also two invited reviews on stereochemistry topics.

Affiliations and Expertise

Professor, Department of Chemistry, University of Mumbai, India

Mohammed Hasan

Dr. Mohammed Hasan has graduated with a PhD in Organic Chemistry form University of Mumbai, working with Prof. Anil V. Karnik on the topic “Studies In Chiral Molecular Recognition”. Post PhD, He began his career as Research Scientist at a pharmaceutical industry, CIPLA Ltd.; working on synthesis of complex, chiral anti-cancer drugs. Later, he went on to gain significant international post-doctoral research experience in Europe and China; working on various synthetic and supramolecular chemistry aspects of stereochemistry. His research interest includes synthetic organic chemistry, chirality, supramolecular chemistry, optical methods and green chemistry. He has many publications in high impact factor international journals. Currently, he is a visiting researcher at the Department of Chemistry, University of Mumbai.

Affiliations and Expertise

Department of Chemistry, University of Mumbai, Mumbai, Maharashtra, India

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