Stem Cells and Cancer in Hepatology - 1st Edition - ISBN: 9780128123010

Stem Cells and Cancer in Hepatology

1st Edition

From the Essentials to Application

Editors: Yun-Wen Zheng
Paperback ISBN: 9780128123010
Imprint: Academic Press
Published Date: 1st June 2018
Page Count: 406
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Description

Stem Cells and Cancer in Hepatology: From the Essentials to Application offers basic scientists and clinicians in the fields of stem cells, hepatology and oncology an overview of the interaction between liver biology, stem cells and cancer. The volume helps these audiences cope with questions they will face regarding how the liver performs regeneration and repair, the role stem cells play in these processes, and the mechanisms by which liver cancers are initiated and developed. Evidence increasingly shows that stem cells in cancerous and normal livers share common characteristics, and liver stem cells have been experimentally shown to be the cells of origin in hepatocellular carcinoma. Thus, thorough understanding of healthy liver stem cells will aid in understanding the mechanisms of live cancer. To understand the biology of hepatic stem cells and to exploit their use for therapy, it is critical to identify and characterize the factors that control the decision between their self-renewal and differentiation under normal physiological conditions and in disease. The field of stem cells and cancer stem cells in hepatology is new and dynamic, making it difficult for researchers and clinicians to acquire grounding when entering the field and to distinguish the most relevant historic and novel studies from those of less significance, and this volume addresses that challenge.

Key Features

  • Addresses both the basic and clinical perspectives of the topic, and both normal and cancer stem cells of the liver
  • Provides coverage of the molecular mechanisms of liver development, the proliferation of hepatic progenitor cells during development, epithelial cell plasticity, generation of hepatocytes by transdifferentiation, liver tissue engineering, and more
  • Study of hepatic stem cells will help readers understand critical events during development, stem cell differentiation towards functional liver cell fate, and tumour initiation

Readership

Basic scientists (graduates, postgraduates and research scholars) and clinicians in the field of stem cells, cancer stem cells, hepatology and oncology

Table of Contents

  1. Molecular mechanisms of liver development: lessons from knockout mice and mutant fish
    2. The regulation of proliferation and maturation of hepatic progenitor cells during liver development
    3. Plasticity of liver epithelial cells in healthy and injured livers
    4. Stem cells in the intestine and liver and the organ size control
    5. Generation of hepatocytes by transdifferentiation
    6. Reconstitution of liver tissue with engineered multicellular spheroids
    7. Role of platelet, blood stem cell and thrombopoietin in liver regeneration and liver diseases
    8. Stem cells in the hepato-biliary system and in the development of cancer
    9. Stem cells in the chronically injured livers and the interaction with their environment
    10. The stem cells in liver cancers and the controversial
    11. Characteristics and clinical significance of Liver Cancer Stem Cells

Details

No. of pages:
406
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128123010

About the Editor

Yun-Wen Zheng

As a stem cell biologist, Dr. Zheng earned his PhD of Medical Science majoring in Physiology/Stem Cell Biology in the University of Tsukuba Graduate School of Medicine, Japan in 2003. From 2003 to present, he has been a team leader for liver and cancer stem cell researches. Dr. Zheng is interested in the identification and isolation of endoderm stem cells as well as liver stem cells in normal and cancer tissues from rodents and human sources; especially for hepatic primordial development and the microenvironment, and drug development, he is trying to generate chimera mouse and rat with humanized livers. Furthermore, for clinical application, he is investigating how to generate the hepatic organoids with cell-cell interactions from the same patient with somatic stem cells from the amnion tissue, umbilical cord and the same source iPS cells. He is also interested in understanding cellular reprogramming and trying cellular therapies, to converse one cell directly into another type in vitro and in vivo.

Affiliations and Expertise

Associate Professor, Department of Advanced Gastroenterological Surgical Science and Technology, Faculty of Medicine, University of Tsukuba, Japan and Visiting Associate Professor, Dept of Regenerative Med, Sch of Med, Yokohama City Uni, Japan and Distinguished Medical Expert and Visiting Professor, Research Center of Stem Cells and Regenerative Medicine, Jiangsu University Hospital, China