Stem Cells and Aging

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process.

With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging.

• Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population
• Addresses the effect of time and age on human stem cells
• Includes chapters from contributors exploring the biology of stem cell aging around the globe

Those involved with stem cell biology, cellular and molecular genetics, general biology, epidemiology, physicians and medical professionals particularly in geriatrics

1. Aging and stability
2. Therapeutic approaches for the treatment of aging-induced stem cell dysfunction
3. Cellular aging and senescence
4. Theories of stem cell aging
5. Aging and neural stem cells
6. Stem cells and neurodegenerative disorders
7. Muscle cells aging and stem cells
8. Progress in human embryonic stem cell research and aging
9. Signaling pathways influencing stem cells self-renewal and differentiation
10. Hematopoietic stem cells and aging: Mechanisms and consequences
11. Potential regeneration of cardiomyocytes