Stem Cell Regulators, Volume 87

1st Edition

Serial Editors: Gerald Litwack
Hardcover ISBN: 9780123860156
eBook ISBN: 9780123860163
Imprint: Academic Press
Published Date: 12th December 2011
Page Count: 520
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Table of Contents



Factors Regulating Pluripotency and Differentiation in Early Mammalian Embryos and Embryo-derived Stem Cells

I. Introduction

II. From Totipotency to Pluripotency

III. Inner Cell Mass (ICM): Pluripotent Cells in the Mammalian Embryo

IV. Embryo-Derived Stem Cells

V. Transcriptional Regulators of Pluripotency in Embryo-Derived Stem Cells

VI. Extrinsic Factors and Signaling Pathways Regulating Pluripotency and Differentiation

VII. Conclusions


Molecular Mediators of Mesenchymal Stem Cell Biology

I. Introduction

II. Mesenchymal Stem Cells

III. Differentiation of MSCs

IV. Self-Renewal

V. MSC Therapy

VI. Immunomodulatory Properties

VII. MI Therapy

VIII. Molecular Mediators of MSC Biology

IX. Enhancing MSC Survival in the Wound

X. Secreted Frizzled-Related Proteins

XI. Mediating MSC Self-Renewal

XII. Conclusions

Insulin and Germline Proliferation in Caenorhabditis elegans

I. Germline Proliferation in C. elegans: A Model for Developmental, Physiological, and Environmental Control of Cell Proliferation

II. C. elegans Germline Development

III. The C. elegans Germ line “Proliferation Versus Differentiation” Decision Is Mediated from the Soma to the Germ line by a Conserved Notch Signaling Pathway

IV. Evidence for Notch-Independent Soma-Germline Signaling Mechanisms That Modulate Germline Proliferation

V. A Counter-Intuitive Assay to Indentify Potential Notch-Independent Mechanisms That Promote the Expansion of the Larval Germline Progenitor Pool

VI. Identification of the Insulin/IGF-Like Receptor (IIR) Pathway Role in Germline Proliferation

VII. IIR Signaling in C. elegans

VIII. Insulin Signaling Promotes the Larval Germline Cell Division Cycle



First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms.

Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.

This volume focuses on stem cell regulators.

Key Features

  • Longest running series published by Academic Press
  • Contributions by leading international authorities


Researchers, faculty, and graduate students interested in cutting-edge review concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested.


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About the Serial Editors

Gerald Litwack Serial Editor

Following a liberal arts education with a major in chemistry and biology at Hobart College, Gerald (Gerry) Litwack earned M.S. and PhD degrees in biochemistry from the University of Wisconsin, Madison where he served as a Lecturer in Enzymology before starting a postdoctoral fellowship from the National Foundation for Infantile Paralysis at the Biochemical Institute of the Sorbonne in Paris. His first academic position was assistant professor of biochemistry at Rutgers University where he started his work on hormone action for six years. During this period, he did a sabbatical at the University of California, Berkeley, where he concentrated on rapid enzyme kinetics. In 1960 he accepted an offer of an associate professorship at the University of Pennsylvania Graduate School of Medicine. In 1964, he was invited to be full professor of biochemistry at The Fels Institute for Cancer Research and Molecular Biology at Temple Medical School, simultaneously with a Career Development Award from the NIH, where he later was named Deputy Director of the Institute and the Laura H. Carnell Professor in biochemistry. Subsequently, he was given the Faculty Research Award. He co-discovered ligandin, later found to be in the family of glutathione S-transferases, enzymes that protect the body from carcinogens. In 1991, he moved to the Jefferson Medical College at Thomas Jefferson University as Professor of Biochemistry, Chair of the Department of Pharmacology and Deputy Director of the Kimmel Cancer Research Institute. Later, he became chair of the combined Department of Biochemistry and Molecular Pharmacology and concurrently held the position of Vice Dean for Research. In 2003, he moved to Los Angeles and from 2004-2006 was a Visiting Scholar at the University of California, Los Angeles, in the Department of Biological Chemistry of the Geffen School of Medicine and, in this period, wrote “Human Biochemistry and Disease” a volume of 1254 pages. In 2007, he moved to Scranton,

Affiliations and Expertise

Toluca Lake, North Hollywood, California, USA