Statistics in Medicine

Statistics in Medicine

2nd Edition - August 4, 2005

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  • Author: Robert Riffenburgh
  • eBook ISBN: 9780080541747

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Medicine deals with treatments that work often but not always, so treatment success must be based on probability. Statistical methods lift medical research from the anecdotal to measured levels of probability. This book presents the common statistical methods used in 90% of medical research, along with the underlying basics, in two parts: a textbook section for use by students in health care training programs, e.g., medical schools or residency training, and a reference section for use by practicing clinicians in reading medical literature and performing their own research. The book does not require a significant level of mathematical knowledge and couches the methods in multiple examples drawn from clinical medicine, giving it applicable context.

Key Features

  • Easy-to-follow format incorporates medical examples, step-by-step methods, and check yourself exercises
  • Two-part design features course material and a professional reference section
  • Chapter summaries provide a review of formulas, method algorithms, and check lists
  • Companion site links to statistical databases that can be downloaded and used to perform the exercises from the book and practice statistical methods

New in this Edition:

  • New chapters on: multifactor tests on means of continuous data, equivalence testing, and advanced methods
  • New topics include: trial randomization, treatment ethics in medical research, imputation of missing data, and making evidence-based medical decisions
  • Updated database coverage and additional exercises
  • Expanded coverage of numbers needed to treat and to benefit, and regression analysis including stepwise regression and Cox regression
  • Thorough discussion on required sample size


Medical and public health students, both at the graduate and undergraduate level; physicians and researchers.

Table of Contents

  • Foreword to the Second Edition, W. M. (Mike) O'Fallon, Professor Emeritus and former Head of Div. of Biostatistics, Mayo Clinic
    Foreword to the First Edition, Vice Adm. Richard A. Nelson, Surgeon General of the U.S. Navy
    I. A Study Course of Fundamentals
    1. Data, Notation, and Some Basic Terms
    2. Distributions
    3. Summary Statistics
    4. Confidence Intervals and Probability
    5. Hypothesis Testing: Concept and Practice
    6. Statistical Testing, Risks, and Odds in Medical Decisions
    7. Sample Size Required for a Study
    8. Statistical Prediction
    9. Epidemiology
    10. Reading Medical Articles
    Answers to Chapter Exercises, Part I
    II. A Reference Guide
    11. Using the Reference Guide
    12. Planning Medical Studies
    13. Finding Probabilities of Error
    14. Confidence Intervals
    15. Tests on Categorical Data
    16. Tests on Ranked Data
    17. Tests on Means of Continuous Data
    18. Multifactor Tests on Means of Continuous Data
    19. Tests on Variances of Continuous Data
    20. Tests on the Distribution Shape of Continuous Data
    21. Equivalence Testing
    22. Sample Size Required for a Study
    23. Modeling and Clinical Decisions
    24. Regression and Correlation Methods
    25. Survival and Time-Series Analysis
    26. Methods You Might Meet, But Not Every Day
    Chapter Summaries
    References and Data Sources
    Tables of Probability Distributions
    Symbol Index
    Subject Index

Product details

  • No. of pages: 672
  • Language: English
  • Copyright: © Academic Press 2005
  • Published: August 4, 2005
  • Imprint: Academic Press
  • eBook ISBN: 9780080541747

About the Author

Robert Riffenburgh

Robert H. Riffenburgh, PhD, advises on experimental design, statistical analysis, and scientific integrity of the approximately 400 concurrent studies at the Naval Medical Center San Diego. A fellow of the American Statistical Association and Royal Statistical Society, he is former Professor and Head, Statistics Department, University of Connecticut, and has been faculty at Virginia Tech., University of Hawaii, University of Maryland, University of California San Diego, San Diego State University, and University of Leiden (The Netherlands). He has been president of his own consulting firm and performed and directed operations research for the U.S. government and for NATO. He has consulted on biostatistics throughout his career, has received numerous awards, and has published more than 140 professional articles.

Affiliations and Expertise

Naval Medical Center, San Diego, California, USA

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