Spinal Oncology An Issue of Neurosurgery Clinics of North America
- 1st Edition, Volume 31-2 - March 7, 2020
- Editors: Mark H. Bilsky, Ilya Laufer
- Language: English
- Hardback ISBN:9 7 8 - 0 - 3 2 3 - 7 3 2 8 6 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 7 3 2 8 7 - 1
This issue of Neurosurgery Clinics, guest edited by Dr. Mark H. Bilsky, will cover key topics in Spinal Oncology. This issue is one of four selected each year by our series… Read more
Purchase options
Institutional subscription on ScienceDirect
Request a sales quoteThis issue of Neurosurgery Clinics, guest edited by Dr. Mark H. Bilsky, will cover key topics in Spinal Oncology. This issue is one of four selected each year by our series consulting editors, Dr. Russell R. Lonser and Dr. Daniel K. Resnick. Topics discussed in this issue will include: Radiation Strategies for Chordoma, New Prospects for Molecular Targets in Chordoma, Surgical Strategies for Chordoma, State of the Art Treatment for Giant Cell Tumors, NOMS and Other Decision Frameworks for Metastatic Disease, Evolving Role of SBRT in Spine Metastases, Hybrid Therapy for Metastatic Disease, Interventional Hybrid Therapy for Metastatic Disease LITT and SBRT, MIS Strategies Changing the Treatment of Spine Tumors, Intradural Tumors, SBRT for Benign Spine Tumors, and Evolving Diagnostic Treatment Paradigms for Spine and Peripheral Nerve Manifestations of NF, among others.
- Cover image
- Title page
- Table of Contents
- Copyright
- Contributors
- Forthcoming Issues
- Preface
- Neurologic, Oncologic, Mechanical, and Systemic and Other Decision Frameworks for Spinal Disease
- Key points
- Introduction
- Treatment algorithms and management frameworks
- Case examples
- Evolving Role of Stereotactic Body Radiation Therapy in the Management of Spine Metastases: Defining Dose and Dose Constraints
- Key points
- Introduction
- Tumor control/symptom response
- Toxicities of spinal stereotactic body radiation therapy
- Radiation myelopathy
- Plexopathy
- Vertebral compression fracture
- Esophageal toxicity
- Summary
- Clinical case discussions
- Case 1. De novo spine metastasis
- Is surgery indicated?
- Is radiation treatment indicated?
- If radiation is indicated, please recommend a dose fractionation schedule, and explain why you chose that treatment schedule
- Overall stereotactic ablative body radiotherapy guidance
- Dose: 24 Gy in 2 fractions
- Normal tissue constraints
- Case 2. Reirradiation
- Is surgery indicated?
- Is radiation treatment indicated?
- If radiation is indicated, please recommend a dose fractionation schedule, and explain why you chose that treatment schedule
- Please include your treatment planning objectives for each situation, with normal tissue constraints
- Case 3. Postoperative case
- Is surgery indicated?
- Is radiation treatment indicated?
- If radiation is indicated, please recommend a dose fractionation schedule, and explain why you chose that treatment schedule
- Please include your treatment planning objectives for each situation, with normal tissue constraints
- Case discussion summary
- Hybrid Therapy for Spinal Metastases
- Key points
- Introduction
- Decision making
- Surgical indications in metastatic spine tumors
- Separation surgery
- Treatment
- Outcomes
- Complications
- Summary
- Minimally Invasive Surgery Strategies: Changing the Treatment of Spine Tumors
- Key points
- Introduction
- Minimally invasive spinal tumor surgery techniques
- Minimally invasive spinal tumor indications
- Summary
- Percutaneous Hybrid Therapy for Spinal Metastatic Disease: Laser Interstitial Thermal Therapy and Spinal Stereotactic Radiosurgery
- Key points
- Introduction
- Spinal laser interstitial thermal therapy
- Spinal stereotactic radiosurgery
- Results
- Future directions
- Summary
- Benign Intradural and Paraspinal Nerve Sheath Tumors: Advanced Surgical Techniques
- Key points
- Introduction
- Nerve sheath anatomy
- Nerve sheath tumor classification
- Surgical indications
- Surgical approaches
- Future directions
- Stereotactic Radiosurgery for Benign Spinal Tumors
- Key points
- Introduction
- Stereotactic radiosurgery: technique, indications, and risks
- Stereotactic radiosurgery: outcomes
- Summary
- Surgical Management of Intramedullary Spinal Cord Tumors
- Key points
- Introduction
- Astrocytoma
- Ependymoma
- Hemangioblastoma
- Other tumors
- Preoperative considerations
- Operative considerations
- Postoperative management
- Future directions
- Summary
- Surgical Strategies for Chordoma
- Key points
- Introduction
- Epidemiology
- Histologic subtypes
- Management background
- Radiation therapy
- Principles of resection
- Radiation Strategies for Spine Chordoma: Proton Beam, Carbon Ions, and Stereotactic Body Radiation Therapy
- Key points
- Introduction
- Technical aspects of radiotherapy for chordomas
- Proton
- Carbon
- Stereotactic body radiation therapy
- Summary
- New Prospects for Molecular Targets for Chordomas
- Key points
- Introduction
- Histopathology and genetics of chordomas
- Brachyury is a driver of chordoma pathogenesis
- Epigenetic regulators in chordomas
- Molecular targeted therapies for chordomas
- The chordoma immune microenvironment
- Preclinical studies in immunotherapy for chordomas
- Clinical studies in immunotherapy for chordomas
- No. of pages: 240
- Language: English
- Edition: 1
- Volume: 31-2
- Published: March 7, 2020
- Imprint: Elsevier
- Hardback ISBN: 9780323732864
- eBook ISBN: 9780323732871
MB
Mark H. Bilsky
Affiliations and expertise
William E. Snee Endowed Chair
Vice Chairman of Clinical Affairs, Neurosurgery
Chief, Multi-Disciplinary Spine Tumor Service
Memorial Sloan Kettering Cancer Center
Professor of Neurosurgery
Weill Medical College of Cornell University
MSKCC
1275 York Avenue
c705
New York, NY 1006IL
Ilya Laufer
Affiliations and expertise
Neurosurgeon and Director of the Minimally Invasive Spine Tumor Surgery Program
Co-Director, Neuro Advanced Care Unit