Spin Labeling

Spin Labeling

Theory and Applications

1st Edition - April 28, 1979

Write a review

  • Editor: Lawrence J. Berliner
  • eBook ISBN: 9781483216416

Purchase options

Purchase options
DRM-free (PDF)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order


Spin Labeling II: Theory and Applications covers spin-labeled biopolymers and its importance to both macromolecular modeling as well as some industrially based problems. The book discusses the methods of saturation-transfer spectroscopy; the spin-probe-spin-label method; and new aspects of nitroxide chemistry. The text also describes the spin-labeled synthetic polymers; the impact that the technique of spin labeling has on pharmacology and on biomedicine; as well as the applications of spin labeling to nucleic acids. Chemists, pharmacologists, biochemists, and people working in the field of biological magnetic resonance will find the book invaluable.

Table of Contents

  • List of Contributors


    1. Saturation-Transfer Spectroscopy

    I. Introduction

    II. Physics of the Very Slow Tumbling Domain

    III. Experimental Methods

    IV. Theory

    V. Computational Efficiency

    VI. Applications of Saturation-Transfer Electron Paramagnetic Resonance

    VII. Anisotropic or Special Motions


    2. The Spin-Probe-Spin-Label Method

    I. Introduction

    II. Theory

    III. Survey of Chemical and Magnetic Properties of Paramagnetic Metal-Ion Probes

    IV. Applications of the Method


    3. New Aspects of Nitroxide Chemistry

    I. Introduction

    II. Structural Features That Make a Nitroxide Stable

    III. Characterization of New Nitroxide Spin Labels and Nitroxide Spectra

    IV. Synthesis of New Stable Nitroxide Spin Labels

    V. Chemical Reactions Involving the Nitroxide Grouping

    VI. Chemical Reactions Not Involving the Nitroxide Grouping

    VII. Dinitroxide Spin Labels

    VIII. Experimental Procedures for the Synthesis of Selected Proxyl and Imidazolidine-Derived Nitroxide Spin Labels


    4. Spin-Labeled Synthetic Polymers

    I. Introduction

    II. Sample Preparation

    III. Analysis in Polymeric Materials

    IV. Motion in Bulk Polymers

    V. Effect of Diluents

    VI. Conformation of Polymers Adsorbed at Solid-Liquid Interfaces

    VII. Conclusion


    5. Spin Labeling in Pharmacology

    I. Introduction

    II. Drug Absorption, Distribution, and Excretion

    III. Drug Metabolism

    IV. Pharmacological Effects of Drugs

    V. Future of Spin-Labeling Studies in Pharmacology


    6. Spin Labeling in Biomedicine

    I. Introduction

    II. Spin Assay

    III. Spin Immunoassay

    IV. Spin-Membrane Immunoassay

    V. Spin Labeling in Carcinogenesis

    VI. Spin Trapping

    VII. In Vivo Electron Spin Resonance


    7. Applications of Spin Labeling to Nucleic Acids

    I. Introduction

    II. Spin Labeling-Spin Probing of Nucleic Acids

    III. Electron Spin Resonance Spectra of Nucleic Acids Containing Spin Labels or Spin Probes

    IV. Monitoring Conformational Changes in Nucleic Acids by Electron Spin Resonance

    V. Molecular Association Studies with Spin-Labeled Nucleic Acids

    VI. Conclusion


    Appendix I

    Appendix II Updated List of Commercial Sources of Spin Labels and Nitroxide Precursors


Product details

  • No. of pages: 374
  • Language: English
  • Copyright: © Academic Press 1979
  • Published: April 28, 1979
  • Imprint: Academic Press
  • eBook ISBN: 9781483216416

About the Editor

Lawrence J. Berliner

Ratings and Reviews

Write a review

There are currently no reviews for "Spin Labeling"