Spin Labeling
Theory and Applications
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Spin Labeling II: Theory and Applications covers spin-labeled biopolymers and its importance to both macromolecular modeling as well as some industrially based problems. The book discusses the methods of saturation-transfer spectroscopy; the spin-probe-spin-label method; and new aspects of nitroxide chemistry. The text also describes the spin-labeled synthetic polymers; the impact that the technique of spin labeling has on pharmacology and on biomedicine; as well as the applications of spin labeling to nucleic acids. Chemists, pharmacologists, biochemists, and people working in the field of biological magnetic resonance will find the book invaluable.
Table of Contents
List of Contributors
Preface
1. Saturation-Transfer Spectroscopy
I. Introduction
II. Physics of the Very Slow Tumbling Domain
III. Experimental Methods
IV. Theory
V. Computational Efficiency
VI. Applications of Saturation-Transfer Electron Paramagnetic Resonance
VII. Anisotropic or Special Motions
References
2. The Spin-Probe-Spin-Label Method
I. Introduction
II. Theory
III. Survey of Chemical and Magnetic Properties of Paramagnetic Metal-Ion Probes
IV. Applications of the Method
References
3. New Aspects of Nitroxide Chemistry
I. Introduction
II. Structural Features That Make a Nitroxide Stable
III. Characterization of New Nitroxide Spin Labels and Nitroxide Spectra
IV. Synthesis of New Stable Nitroxide Spin Labels
V. Chemical Reactions Involving the Nitroxide Grouping
VI. Chemical Reactions Not Involving the Nitroxide Grouping
VII. Dinitroxide Spin Labels
VIII. Experimental Procedures for the Synthesis of Selected Proxyl and Imidazolidine-Derived Nitroxide Spin Labels
References
4. Spin-Labeled Synthetic Polymers
I. Introduction
II. Sample Preparation
III. Analysis in Polymeric Materials
IV. Motion in Bulk Polymers
V. Effect of Diluents
VI. Conformation of Polymers Adsorbed at Solid-Liquid Interfaces
VII. Conclusion
References
5. Spin Labeling in Pharmacology
I. Introduction
II. Drug Absorption, Distribution, and Excretion
III. Drug Metabolism
IV. Pharmacological Effects of Drugs
V. Future of Spin-Labeling Studies in Pharmacology
References
6. Spin Labeling in Biomedicine
I. Introduction
II. Spin Assay
III. Spin Immunoassay
IV. Spin-Membrane Immunoassay
V. Spin Labeling in Carcinogenesis
VI. Spin Trapping
VII. In Vivo Electron Spin Resonance
References
7. Applications of Spin Labeling to Nucleic Acids
I. Introduction
II. Spin Labeling-Spin Probing of Nucleic Acids
III. Electron Spin Resonance Spectra of Nucleic Acids Containing Spin Labels or Spin Probes
IV. Monitoring Conformational Changes in Nucleic Acids by Electron Spin Resonance
V. Molecular Association Studies with Spin-Labeled Nucleic Acids
VI. Conclusion
References
Appendix I
Appendix II Updated List of Commercial Sources of Spin Labels and Nitroxide Precursors
Index
Product details
- No. of pages: 374
- Language: English
- Copyright: © Academic Press 1979
- Published: April 28, 1979
- Imprint: Academic Press
- eBook ISBN: 9781483216416