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Special Topics and General Characteristics - 1st Edition - ISBN: 9781483227870, 9781483270661

Special Topics and General Characteristics

1st Edition

Diseases Caused by Protista

Editors: David Weinman Miodrag Ristic
eBook ISBN: 9781483270661
Imprint: Academic Press
Published Date: 1st January 1968
Page Count: 508
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Infectious Blood Diseases of Man and Animals: Diseases Caused by Protista, Volume I: Special Topics and General Characteristics focuses on the critical analysis of metabolic, immuno-pathologic, taxonomic, ultrastructural, locomotor, ecologic, zoonotic, and other features of the protistan blood diseases. The selection first offers information on ecology and host-parasite relationship; basis of host cell-parasite specificity; and abrogation of immunological tolerance as a model for autoimmunity. Topics include interactions in disease transmission, types of host-parasite relationship, and experimental abrogation of tolerance. The text then takes a look at autoimmune response and pathogenesis of blood parasite disease and blood parasite antigens and antibodies.
The publication examines the zoonotic potential of blood parasites, including diseases caused by bacteria and spirochetes and trypanosomiasis. The text then focuses on the cultivation and nutritional requirements and biological leads to chemotherapy of blood Protista. Discussions focus on organisms developing within the blood cells; energy metabolism and chemotherapeutic targets; and protozoa developing primarily in the plasma.
The book is a valuable reference for readers interested in the diseases caused by Protista.

Table of Contents

List of Contributors



Contents of Volume II

Part I: Special Topics

1. Ecology and Host-Parasite Relationship

I. Types of Host-Parasite Relations

II. Relation of Vertebrate Host Group to Parasite Group

III. Patterns of Host Response to Blood Parasites

IV. Relation of Parasite Group to Vector Group

V. Interactions in Disease Transmission

VI. Landscape Epidemiology


2. Basis of Host Cell-Parasite Specificity

I. Introduction

II. Factors Affecting Host Cell-Parasite Specificity in the Vertebrate Host

III. Susceptibility of Arthropod Vectors to Protozoan Parasites

IV. Conclusion


3. Abrogation of Immunological Tolerance as a Model for Autoimmunity

I. Introduction

II. The Immunological Recognition System

III. Experimental Abrogation of Tolerance

IV. Conclusions


4. Autoimmune Response and Pathogenesis of Blood Parasite Diseases

I. The Immunological Basis of Anemia in Erythrocytic Infections

II. Concepts of Autoimmune Response

III. Immunopathology

IV. Protection Resulting from the Autoimmune Response


5. Blood Parasite Antigens and Antibodies

I. Plasmodia

II. Trypanosomes

III. Theileria

IV. Babesia

V. Anaplasma

VI. Eperythrozoon and Haemobartonella


6. Zoonotic Potential of Blood Parasites

I. Introduction

II. Definitions

III. Diseases Caused by Bacteria and Spirochetes

IV. Trypanosomiasis

V. Malaria

VI. Babesiosis


Part II: General Characteristics of the Blood Protists

7. Definition and Classification

I. The Concept of Protista

II. Problems of Protistan Taxonomy

III. Rules of Nomenclature

IV. Definition of Blood Protists

V. Skeletal Scheme of Classification

VI. Annotated Bibliography

8. Cultivation and Nutritional Requirements

I. Introduction

II. Protozoa Developing Primarily in the Plasma: The Hemoflagellates

III. Organisms Developing within the Blood Cells


9. Some Biological Leads to Chemotherapy of Blood Protista, Especially Trypanosomatidae

I. Introduction: Need for Better Screening Methods for Antiprotozoal Agents

II. Pitfalls in Screening for Antiprotozoal Agents

III. The Antimetabolite Approach: Ways to Identify New Metabolites as Potential Chemotherapeutic Targets

IV. Seductions of Molecular Biology; DNA Binding

V. Energy Metabolism and Chemotherapeutic Targets

VI. Prospects


10. The Fine Structure

I. Introduction

II. Protozoa Invading Blood Cells

III. Protozoa Not Invading Blood Cells (Trypanosomes)

IV. Conclusion and General Remarks


11. Development and Reproduction (Vertebrate and Arthropod Host)

I. Introduction

II. The Trypanosomatidae

III. The Plasmodiidae


12. Preservation and Storage in Vitro

I. Preservation by Freezing

II. Preservation by Freeze-Drying

III. Results Obtained


13. Investigational Problems and the Mechanisms of Inheritance in Blood Protozoa

I. Introduction

II. Cytological Analysis of Genetic Systems

III. Genetic Markers

IV. Developmental Genetics

V. Population Dynamics


14. Locomotion of Blood Protists

I. Hydrodynamic and Thermodynamic Problems

II. Locomotion by Active Body Flections

III. Locomotion of Flagellated Protozoa

IV. Summary


Author Index

Subject Index


No. of pages:
© Academic Press 1968
1st January 1968
Academic Press
eBook ISBN:

About the Editors

David Weinman

Miodrag Ristic

Ratings and Reviews