Special Topics and General Characteristics

List of Contributors

Foreword

Preface

Contents of Volume II

Part I: Special Topics


1. Ecology and Host-Parasite Relationship

I. Types of Host-Parasite Relations

II. Relation of Vertebrate Host Group to Parasite Group

III. Patterns of Host Response to Blood Parasites

IV. Relation of Parasite Group to Vector Group

V. Interactions in Disease Transmission

VI. Landscape Epidemiology

References


2. Basis of Host Cell-Parasite Specificity

I. Introduction

II. Factors Affecting Host Cell-Parasite Specificity in the Vertebrate Host

III. Susceptibility of Arthropod Vectors to Protozoan Parasites

IV. Conclusion

References


3. Abrogation of Immunological Tolerance as a Model for Autoimmunity

I. Introduction

II. The Immunological Recognition System

III. Experimental Abrogation of Tolerance

IV. Conclusions

References


4. Autoimmune Response and Pathogenesis of Blood Parasite Diseases

I. The Immunological Basis of Anemia in Erythrocytic Infections

II. Concepts of Autoimmune Response

III. Immunopathology

IV. Protection Resulting from the Autoimmune Response

References


5. Blood Parasite Antigens and Antibodies

I. Plasmodia

II. Trypanosomes

III. Theileria

IV. Babesia

V. Anaplasma

VI. Eperythrozoon and Haemobartonella

References


6. Zoonotic Potential of Blood Parasites

I. Introduction

II. Definitions

III. Diseases Caused by Bacteria and Spirochetes

IV. Trypanosomiasis

V. Malaria

VI. Babesiosis

References

Part II: General Characteristics of the Blood Protists


7. Definition and Classification

I. The Concept of Protista

II. Problems of Protistan Taxonomy

III. Rules of Nomenclature

IV. Definition of Blood Protists

V. Skeletal Scheme of Classification

VI. Annotated Bibliography


8. Cultivation and Nutritional Requirements

I. Introduction

II. Protozoa Developing Primarily in the Plasma: The Hemoflagellates

III. Organisms Developing within the Blood Cells

References


9. Some Biological Leads to Chemotherapy of Blood Protista, Especially Trypanosomatidae

I. Introduction: Need for Better Screening Methods for Antiprotozoal Agents

II. Pitfalls in Screening for Antiprotozoal Agents

III. The Antimetabolite Approach: Ways to Identify New Metabolites as Potential Chemotherapeutic Targets

IV. Seductions of Molecular Biology; DNA Binding

V. Energy Metabolism and Chemotherapeutic Targets

VI. Prospects

References


10. The Fine Structure

I. Introduction

II. Protozoa Invading Blood Cells

III. Protozoa Not Invading Blood Cells (Trypanosomes)

IV. Conclusion and General Remarks

References


11. Development and Reproduction (Vertebrate and Arthropod Host)

I. Introduction

II. The Trypanosomatidae

III. The Plasmodiidae

References


12. Preservation and Storage in Vitro

I. Preservation by Freezing

II. Preservation by Freeze-Drying

III. Results Obtained

References


13. Investigational Problems and the Mechanisms of Inheritance in Blood Protozoa

I. Introduction

II. Cytological Analysis of Genetic Systems

III. Genetic Markers

IV. Developmental Genetics

V. Population Dynamics

References


14. Locomotion of Blood Protists

I. Hydrodynamic and Thermodynamic Problems

II. Locomotion by Active Body Flections

III. Locomotion of Flagellated Protozoa

IV. Summary

References

Author Index

Subject Index