1. Introduction: Smart materials in biomedicine
2. Smart polymeric nanoparticles
Clara Mattu, Giulia Brachi and Gianluca Ciardelli
3. Smart liposomes for drug delivery
Tianshu Li and Shinji Takeoka
4. Pharmacologically-active plant-derived natural products
Adela Pintea, Dumitrita Rugina and Zorița Diaconeasa
5. Nanostructured cyanoacrylates: biomedical applications
6. Applications of carbon nanotubes in the biomedical field
7. Carbon nanomaterials for nanomedicine
Silvia Giordani and Marta d'Amora
8. Silica nanoparticles applications in the biomedical field
Larissa Brentano Capeletti, Lívia Mesquita Dias Loiola, Agustin Silvio Picco Sr., Michelle da Silva Liberato and Mateus Borba Cardoso
9. Magnetic nanoparticles and their bio-applications
10. TiO2 nanotube arrays as smart platforms for biomedical applications
Giada Graziana Genchi, Yiqi Cao and Tejal Desai
11. Antioxidant Inorganic nanoparticles and their potential applications in biomedicine
William Thomas Self and Austin Burns
12. Zinc oxide nanostructures in biomedicine
Luisa Racca, Marta Canta, Bianca Dumontel, Andrea Ancona, Tania Limongi, Nadia Garino, Marco Laurenti, Giancarlo Canavese and Valentina Cauda
13. Smart inorganic nanoparticles for wireless cell stimulation
Attilio Marino, Matteo Battaglini, Ilaria Pezzini and Gianni Ciofani
14. Nano-sized optical thermometers
Satoshi Arai and Madoka Suzuki
15. Advanced optical microscopy techniques for the investigation of cell-nanoparticle interactions
Natalia Feiner-Gracia, Sílvia Pujals, Pietro Delcanale and Lorenzo Albertazzi
Nanotechnology has enabled an unprecedented control of the interactions between materials and biological entities, from the microscale down to the molecular level. Nanosurfaces and nanostructures have been used to mimic or interact with biological microenvironments, to support specific biological functions such as cell adhesion, mobility and differentiation, as well as tissue healing. Recently, a new paradigm has been proposed for nanomedicine to exploit the intrinsic properties of nanomaterials as active devices rather than as passive structural units or carriers for medications. Here, the nanomaterial itself is the active device that responds to external stimuli by modifying its intrinsic chemical and/or physical characteristics, so as to provide useful bio-stimulation and/or bio-signaling.
Smart Nanoparticles for Biomedicine explores this ‘active’ category, introducing smart nanoparticles that change their structural or functional properties in response to specific external stimuli (electric or magnetic fields, electromagnetic radiation, ultrasound, etc.). Particular attention is given to multifunctional nanostructured materials that are pharmacologically active and that can be actuated by virtue of their magnetic, dielectric, optically-active, redox-active, or piezoelectric properties.
This is an important reference resource, that will be of great value to readers in biomaterials and biomedical research who want to learn more about how smart nanoparticles can be used to create more effective treatment solutions.
- Discusses the synthesis, the characterization and the applications of a new generation of smart nanoparticles, for nanomedicine applications
- Explores the problems related to the biocompatibility of a range of nanoparticles, outlining potential solutions
- Describes techniques for manipulating specific classes of nanoparticles for a variety of treatment types
Materials scientists, life science scientists, bioengineers, pharmacologists at both graduate academic and practitioner levels
- No. of pages:
- © Elsevier 2018
- 1st June 2018
- Paperback ISBN:
Gianni Ciofani (born on August 14th, 1982) is Associate Professor at the Polytechnic University of Torino, Department of Mechanical and Aerospace Engineering (Torino, Italy) and Senior Researcher at the Italian Institute of Technology (IIT), Smart Bio-Interfaces Research Line (Pontedera, Pisa, Italy). He received his Master Degree in Biomedical Engineering (with honors) from the University of Pisa, Italy, in July 2006, and, in the same year, his Diploma in Engineering (with honors) from the Scuola Superiore Sant’Anna of Pisa, Italy. In January 2010, he obtained his Ph.D. in Innovative Technologies (with honors) from the Scuola Superiore Sant’Anna. From January 2010 to August 2013 he was Post-Doc at the IIT, Center for Micro-BioRobotics @SSSA, where, from September 2013 to October 2015, he was Researcher in the framework of the Smart Materials Platform. In October 2015 he was appointed Associate Professor at the Polytechnic University of Torino, maintaining his research activity in IIT where he is currently Principal Investigator of the Smart Bio-Interfaces Research Line. His main research interests are in the field of smart nanomaterials for nanomedicine, bio/non-bio interactions, and biology in altered gravity conditions. He is coordinator or unit leader of many grants/projects, and in 2016 he was awarded a European Research Council (ERC) Starting Grant. Gianni Ciofani is author of more than 100 ISI papers (H-index 25, excluding self-citations), 3 edited books, and 12 book chapters. He delivered about 25 invited talks/lectures in international contexts and, for his research activity, he was awarded several national and international prizes. He serves as Reviewer for more than 100 international journals and as Editorial Board Member of the International Journal of Biological Engineering and of Advances in Nano Research; he is Senior Editor of Nanomaterials & Nanosciences and Associate Editor of Frontiers in Nanobiotechnology. Gianni Ciofani is professor of Biomimetic Systems and Bionanotechnologies, and supervisor of several M.Sc. and Ph.D. students.
Associate Professor at the Polytechnic University of Torino, Department of Mechanical and Aerospace Engineering (Torino, Italy) and Senior Researcher at the Italian Institute of Technology (IIT), Smart Bio-Interfaces Research Line (Pontedera, Pisa, Italy).