
Small Molecule Drug Discovery
Methods, Molecules and Applications
Description
Key Features
- Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery
- Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics
- Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches
- Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules
Readership
Researchers, scientists and graduate students in organic synthesis, chemical biology and drug discovery. Researchers and scientists in chemoinformatics, bioorganic chemistry and combinatorial chemistry
Table of Contents
1. Synthetic Approaches Toward Small Molecule Libraries
2. Chemical Reactions for Building Small Molecules
3. Chemoinformatics to Assess Chemical Diversity and Complexity of Small Molecules
4. Virtual Screening of Small Molecule Libraries
5. Biophysical Methods for Screening and Characterization of Small Molecules
6. Small Molecule Peptidomimetics: Principles, Molecules, and Applications
7. sp2-Iminosugars as Chemical Mimics for Glycodrug Design
8. Synthesis and Biological Properties of Spiroacetal-containing Small Molecules
9. Centrocountins: Synthesis and Chemical Biology of Nature Inspired Indoloquinolizines
10. PPIs as Therapeutic Targets for Anti-cancer Drug Discovery: The Case Study of MDM2 and BET Bromodomain Inhibitors
11. Discovery of Small Molecules for the Treatment of Alzheimer's Disease
Product details
- No. of pages: 356
- Language: English
- Copyright: © Elsevier 2019
- Published: November 20, 2019
- Imprint: Elsevier
- eBook ISBN: 9780128183502
- Paperback ISBN: 9780128183496