Sleep Disorders Part 1 offers a glimpse of developments that focus on diagnostic techniques in the field of neurobiology of sleep. This part discusses the models of the rapid eye movement (REM) sleep mechanism; issues regarding sleep states, stages, and memory consolidation; and advances in the understanding of the sleep-wake genes, gene products, the circadian clock, and the role of sleep duration. This book explains noninvasive neuroimaging studies, particularly positron emission tomographic and single photon emission computed tomographic scans. It further discusses advances in clinical science, including concepts about neurobiology of sleep, narcolepsy-cataplexy, therapy, and laboratory techniques. The significant advances in therapy have led to the addition of new drugs for the treatment of different sleeping disorders, as described in this book. Sleep is essential to humans. Awareness of its true importance leads to the development and acceptance of sleep medicines in the market.

Key Features

* Clinical data on groundbreaking advancements in the understanding of basic sleep science
* Invaluable information on new therapies and drug protocols for sleep disorders
* A state-of-the-art reference that includes the role of genetics in sleep medicine


Neuroscience research workers

Table of Contents

Foreword Preface Acknowledgments List of contributors Section 1 History of sleep medicine     1. History of sleep medicine Section 2 Basic science and methods     2. Normal sleep-recording and scoring techniques     3. Assessment of daytime sleepiness     4. Actigraphic monitoring of sleep and circadian rhythms     5. Video recordings and video polysomnography     6. Functional neuroimaging in sleep, sleep deprivation, and sleep disorders Section 3 Basic mechanisms of sleep     7. The phylogeny of sleep     8. Ontogeny of EEG sleep from neonatal through infancy periods     9. Neurobiology of waking and sleeping     10. Neurobiology of REM sleep     11. Neurochemistry of sleep: an overview of animal experimental work     12. Molecular neurobiology of sleep     13. Manifestations and functional implications of sleep homeostasis     14. Thermoregulation in wakefulness and sleep in humans     15. Cytokines in immune function and sleep regulation     16. Endocrine and metabolic changes during sleep     17. Sleep, memory, and molecular neurobiology Section 4 Clinical aspects of sleep disorders     18. Epidemiology of sleep disorders     19. Cardiovascular and cerebrovascular physiology in sleep     20. Cardiovascular diseases and sleep apnea     21. Alterations in gastrointestinal functioning during sleep     22. Sleep and genitourinary systems: physiology and disorders     23. Sleep enuresis     24. Respiratory physiology in sleep and wakefulness     25. Obstructive sleep apnea: diagnosis, risk factors, and pathophysiology     26. Upper-airway resistance syndrome     27. Central sleep apnea     28. Positive-pressure treatment of obstructive sleep apnea syndrome     29. Medical and surgical treatment of obstructive sleep apnea syndrome, including dental appliances     30. Noninvasive positive ventilation in the treatment of sleep-related breathing disorders     31. Sleep and pulmonary diseases     32. Sleep-associated respiratory dis


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About the editors

Pasquale Montagna

Affiliations and Expertise

Department of Neurological Sciences, University of Bologna, Italy

Sudhansu Chokroverty

Affiliations and Expertise

Professor and Co-Chair of Neurology, Program Director, Clinical Neurophysiology and Sleep Medicine, New Jersey Neuroscience Institute at JFK Medical Center and Seton Hall University, Edison, New Jersey; Clinical Professor of Neurology, Robert Wood Johnson Medical School, New Brunswick, New Jersey